Patents by Inventor David Pacenti

David Pacenti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR MEASURING UBIQUITIN CARBOXY-TERMINAL HYDROLASE L1 LEVELS IN BLOOD
    Publication number: 20220128579
    Abstract: Disclosed herein are improved methods of processing, measuring, and detecting levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) in blood samples taken from a human subject at time points within about 8 hours (or about 8 hours or less) after obtaining the sample from the subject. UCH-L1 is an early biomarker for traumatic brain injury (TBI), and there is a need for improved methods for assessing UCH-L1 in blood can aid in the diagnosis and evaluation of a human subject who has sustained or may have sustained a head injury.
    Type: Application
    Filed: September 30, 2021
    Publication date: April 28, 2022
    Inventors: Gangamani S. Beligere, Melissa B. Brennan, Jessica Grieshaber, David Pacenti, Saul A. Datwyler, John M. Ramp
  • METHODS FOR AIDING IN THE DIAGNOSIS OF TRAUMATIC INJURY BY MEAURING AT LEAST ONE BIOMARKER THAT IS UCH-L1
    Publication number: 20220050111
    Abstract: Disclosed herein are methods of aiding in a diagnosis of a traumatic brain injury (TBI) in a subject suspected of having sustained or known to have sustained an injury to the head, by detecting at least one biomarker, wherein the at least one biomarker is ubiquitin carboxy terminal hydrolase L1 (UCH-L1).
    Type: Application
    Filed: February 4, 2021
    Publication date: February 17, 2022
    Inventors: Saul A. Datwyler, Beth McQuiston, Gangamani Beligere, Elaine Brate, John Ramp, David Pacenti
  • METHODS FOR AIDING IN THE DIAGNOSIS OF A TRAUMATIC BRAIN INJURY BY MEASURING AT LEAST ONE BIOMARKER THAT IS GFAP
    Publication number: 20220003786
    Abstract: Disclosed herein are methods of aiding in a diagnosis of a traumatic brain injury (TBI) in a subject suspected of having sustained or known to have sustained an injury to the head, by detecting at least one biomarker, wherein the at least one biomarker is glial fibrillary acidic protein (GFAP).
    Type: Application
    Filed: January 7, 2021
    Publication date: January 6, 2022
    Inventors: Saul A. Datwyler, Beth McQuiston, Elaine Brate, John Ramp, David Pacenti
  • Methods for measuring ubiquitin carboxy-terminal hydrolase L1 levels in blood
    Patent number: 11169159
    Abstract: Disclosed herein are improved methods of processing, measuring, and detecting levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) in blood samples taken from a human subject at time points within about 8 hours (or about 8 hours or less) after obtaining the sample from the subject. UCH-L1 is an early biomarker for traumatic brain injury (TBI), and there is a need for improved methods for assessing UCH-L1 in blood can aid in the diagnosis and evaluation of a human subject who has sustained or may have sustained a head injury.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: November 9, 2021
    Assignee: Abbott Laboratories
    Inventors: Gangamani S. Beligere, Melissa B. Brennan, Jessica Grieshaber, David Pacenti, Saul A. Datwyler, John M. Ramp
  • METHODS FOR MEASURING UBIQUITIN CARBOXY-TERMINAL HYDROLASE L1 LEVELS IN BLOOD
    Publication number: 20190033327
    Abstract: Disclosed herein are improved methods of processing, measuring, and detecting levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) in blood samples taken from a human subject at time points within about 8 hours (or about 8 hours or less) after obtaining the sample from the subject. UCH-L1 is an early biomarker for traumatic brain injury (TBI), and there is a need for improved methods for assessing UCH-L1 in blood can aid in the diagnosis and evaluation of a human subject who has sustained or may have sustained a head injury.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 31, 2019
    Inventors: Gangamani S. Beligere, Melissa B. Brennan, Jessica Grieshaber, David Pacenti, Saul A. Datwyler, John M. Ramp
  • METHODS OF ASSESSING UCH-L1 STATUS IN PATIENT SAMPLES
    Publication number: 20180106800
    Abstract: Disclosed herein are improved methods of assessing ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) status in a subject (such as for example, as a measure of traumatic brain injury or for other clinical reasons). Also disclosed herein are methods of assessing a subject's glial fibrillary acid protein (GFAP) and UCH-L1 status in subject (such as, for example as a measure of traumatic brain injury or for other clinical reasons).
    Type: Application
    Filed: October 2, 2017
    Publication date: April 19, 2018
    Inventors: Saul A. Datwyler, Beth McQuiston, Gangamani Beligere, Elaine Brate, John Ramp, David Pacenti
  • METHODS OF ASSESSING GFAP STATUS IN PATIENT SAMPLES
    Publication number: 20180106818
    Abstract: Disclosed herein are improved methods of assessing Glial fibrillary acidic protein (GFAP) status in a subject (such as for examples, as a measure of traumatic brain injury or for other clinical reasons).
    Type: Application
    Filed: October 2, 2017
    Publication date: April 19, 2018
    Inventors: Saul A. Datwyler, Beth McQuiston, Elaine Brate, John Ramp, David Pacenti