Abstract: The present disclosure provides human interleukin 4 receptor alpha antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of inflammatory diseases, such as type 2 inflammatory diseases.

Abstract: The present disclosure provides human tumor necrosis factor alpha antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of autoimmune and inflammatory diseases.

Abstract: Ultrasonic pipeline inspection apparatus which utilizes two different wave modes (e.g. a horizontally polarized shear mode and a symmetric Lamb wave mode) to discriminate different defect types by comparing corresponding signals collected from defects. EMATs may detect the signals. The detected amplitudes of the collected signals from both wave modes are compared to calculate a ratio, which may be compared with a distribution of ratio values for known defects to evaluate the type of defect detected. The apparatus may be a sensor module mountable on a pipeline vehicle and having a plurality of sensors distributed around its periphery.

Abstract: Ultrasonic pipeline inspection apparatus which utilises two different wave modes (e.g. a horizontally polarised shear mode and a symmetric Lamb wave mode) to discriminate different defect types by comparing corresponding signals collected from defects. EMATs may detect the signals. The detected amplitudes of the collected signals from both wave modes are compared to calculate a ratio, which may be compared with a distribution of ratio values for known defects to evaluate the type of defect detected. The apparatus may be a sensor module mountable on a pipeline vehicle and having a plurality of sensors distributed around its periphery.

Abstract: An electromagnetic acoustic transducer (12, 24) has one or a plurality of magnets for applying a DEC magnetic field to a material (4, 25) under test, and an electrical coil (2, 23) supplied by an alternating current source for, providing an AC magnetic flux within the material under test. A wear plate (16, 26) engages with an slides along the surface of the material under test. The wear plate (16, 26) is of electrically conductive ferromagnetic material and has apertures (17, 31) therein. Thus, both the DC field and the ACT flux can penetrate the material under test and create ultrasonic vibration of that material.

Abstract: An electromagnetic acoustic transducer (EMAT) for inspecting an object is provided. The EMAT includes a magnet configured to generate a magnetic field in an object and a radio frequency coil configured to induce eddy currents on a surface of the object. The EMAT further includes a laminated wear plate disposed over the magnet and the radio frequency coil and configured to shield the magnet and the radio frequency coil from damage.

Abstract: An electromagnetic acoustic transducer (12, 24) has one or a plurality of magnets for applying a DEC magnetic field to a material (4, 25) under test, and an electrical coil (2, 23) supplied by an alternating current source for, providing an AC magnetic flux within the material under test. A wear plate (16, 26) engages with an slides along the surface of the material under test. The wear plate (16, 26) is of electrically conductive ferromagnetic material and has apertures (17, 31) therein. Thus, both the DC field and the ACT flux can penetrate the material under test and create ultrasonic vibration of that material.

Abstract: A portable apparatus for measuring characteristics of hydraulic features in rivers and streams that are unwadeable. The apparatus consists of a tripod base, a horizontal boom that articulates on the tripod, a carriage configured to travel on the boom, and a measuring rod that can be moved vertically on the carriage. These components are designed to be portable, carried by hand or in a raft, and are adapted to be assembled on rugged terrain. The measuring rod is configured to accommodate sensors to measure characteristics such as channel topography, water surface topography, air-water mixing, velocity pressure differentials, and lift and drag forces. The apparatus can be adapted for measurement and monitoring in harsh environments such as volcanic lakes, fumaroles, and hot springs. The invention can be utilized for sampling air quality, weather, water quality, fluid mechanics (gas or liquid), soils, sediments, volcanic gases and hydrothermal fluids.

Abstract: An electromagnetic acoustic transducer for exciting ultrasound in a ferromagnetic material under test (2), includes a magnetic unit (6) arranged to be moved relative to the material under test (2) to magnetize a surface layer of the material, and an electrical winding (8) supplied by an alternating current source, the magnetic unit (6) and the electric winding (8), in use, being applied in sequence to the material under test (2) whereby the electrical winding (8) is positioned adjacent the material subsequent to magnetization thereof by the magnetic unit (8), the alternating magnetic flux created by the winding (8) interacting with the remanent magnetization of the material to create ultrasonic vibration of the material.

Abstract: A portable apparatus for measuring characteristics of hydraulic features in rivers and streams that are unwadeable. The apparatus consists of a tripod base, a horizontal boom that articulates on the tripod, a carriage configured to travel on the boom, and a measuring rod that can be moved vertically on the carriage. These components are designed to be portable, carried by hand or in a raft, and are adapted to be assembled on rugged terrain. The measuring rod is configured to accommodate sensors to measure characteristics such as channel topography, water surface topography, air-water mixing, velocity pressure differentials, and lift and drag forces. The apparatus can be adapted for measurement and monitoring in harsh environments such as volcanic lakes, fumaroles, and hot springs. The invention can be utilized for sampling air quality, weather, water quality, fluid mechanics (gas or liquid), soils, sediments, volcanic gases and hydrothermal fluids.

Abstract: An electromagnetic acoustic transducer for exciting ultrasound in a ferromagnetic material under test (2), comprises magnetic means (6) arranged to be moved relative to the material under test (2) to magnetise a surface layer of the material, and an electrical winding (8) supplied by an alternating current source, the magnetic means (6) and the electric winding (8), in use, being applied in sequence to the material under test (2) whereby the electrical winding (8) is positioned adjacent the material subsequent to magnetisation thereof by the magnetic means (8), the alternating magnetic flux created by the winding (8) interacting with the remanent magnetisation of the material to create ultrasonic vibration of the material.

Abstract: A pipeline inspection pig for locating crack-like defects (10) in pipeline walls (8) comprises at least one transmit transducer (T) for transmitting ultrasound energy into the pipeline wall (8), and at least one associated receive transducer (R) located adjacent the transmit transducer (T), the arrangement being such that, for a given defect (10) in the pipeline wall (8), ultrasound energy within the pipeline wall (8) is incident on the defect (10), part of said energy being reflected by the defect (10) back to the receive transducer (8) in the form of a first data stream, and the remainder of said energy passing through the defect (10) to be attenuated thereby and thence returned to the receive transducer (R) in the form of a second data stream, interpretation of the first and second data streams enabling the location of the defect (10) to be determined.