Abstract: Provided herein are a Heartland virus vaccine composition including a messenger ribonucleic acid (mRNA) including an open reading frame (ORF) encoding Gn or Gc of Heartland virus, a Heartland virus vaccine composition comprising a messenger ribonucleic acid (mRNA) comprising an open reading frame (ORF) encoding Gn or Gc of Heartland virus fused with human collagen type I alpha 1 (COL1A1) signal peptide, and a method of inducing immune response against Heartland virus by administering an effective amount of the Heartland virus vaccine composition to a subject in need thereof.

Abstract: Provided herein are a shingles vaccine composition including a messenger ribonucleic acid (mRNA) including an open reading frame (ORF) encoding varicella Zoster virus (VZV) glycoprotein E (gE)(which is soluble VZV gE or full-length VZV gE) and a method of inducing immune response against Shingles by administering an effective amount of the Shingles vaccine composition to a subject in need thereof.

Abstract: Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.

Abstract: A waste bag dispensing system comprising a base member defining a cavity configured to receive a waste bag roll, a cap configured to removably secure to the base member, a slit opening extending through the base member, a separator, and a securement means to secure the system to an object, such as a leash. The roll may comprise a plurality of waste bags in perforated connection around a hollow spool configured to removably receive a base friction post and a cap friction post, the friction posts applying a lateral pressure on the waste bag roll and a tab may apply pressure on an exterior of the roll. An end of the roll may extend through the slit opening towards the separator which may engage the perforated connection and permit the removal of one waste bag from the roll. The securement means may comprise a lateral and vertical stability means.

Abstract: The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents.

Abstract: Water-in-hydrocarbon emulsions, preferably comprising a fluorinated or perfluorinated hydrocarbon continuous phase, a discontinuous aqueous phase, and a surfactant or mixture of surfactants. The emulsions contain pharmacologically active agents, such as endothelin receptor antagonists, and are particularly suitable for pulmonary drug delivery. The emulsions are useful for treating pulmonary diseases or disorders, including pulmonary hypertension conditions, such as acute pulmonary arterial hypertension.

Abstract: A method, system and controller is provided for navigating a network of options on an interactive display. A navigation pane on a display is defined (1201) and a first set of options is displayed in the navigation pane as divided sub-regions which may be separated by lines (1202). The options corresponding to the sub-regions may be identified with text or other meaningful symbols or images. Sub-region area may correspond to relative importance of each option. A selector is monitored for activation when a pointer is within one of the sub-regions (1203). If the selected option is a node the sub-region associated with the selected option may be magnified in a zooming motion and the second set of options is displayed in the navigation pane (1204, 1206, 1207).

Abstract: A method, system and controller is provided for navigating a network of options on an interactive display. A navigation pane on a display is defined (1201) and a first set of options is displayed in the navigation pane as divided sub-regions which may be separated by lines (1202). The options corresponding to the sub-regions may be identified with text or other meaningful symbols or images. Sub-region area may correspond to relative importance of each option. A selector is monitored for activation when a pointer is within one of the sub-regions (1203). If the selected option is a node the sub-region associated with the selected option may be magnified in a zooming motion and the second set of options is displayed in the navigation pane (1204, 1206, 1207).

Abstract: A method, system and controller is provided for navigating a network of options on an interactive display. A navigation pane on a display is defined (1201) and a first set of options is displayed in the navigation pane as divided subregions which may be separated by lines (1202). The options corresponding to the subregions may be identified with text or other meaningful symbols or images. Subregion area may correspond to relative importance of each option. A selector is monitored for activation when a pointer is within one of the subregions (1203). If the selected option is a node the subregion associated with the selected option may be magnified in a zooming motion and the second set of options is displayed in the navigation pane (1204, 1206, 1207).

Abstract: A method, system and controller is provided for searching a database containing data items with a user via a user inter the method comprising the steps of specifying an initial search subset of some or all of the data items in the database (1201); identifying representatives of each of a number of data categories in the search subset (1203); displaying the representatives on the user interface (1204); selecting one or more of the representatives (1205); specifying a refined search subset of data items in the search subset within the data categories corresponding to the selected representatives (1207); and repeating the steps of identifying and displaying representatives for the refined search subset.

Abstract: A method, system and controller is provided for searching a database containing data items with a user via a user interface, the method comprising the steps of specifying an initial search subset of some or all of the data items in the database (1201); identifying representatives of each of a number of data categories in the search subset (1203); displaying the representatives on the user interface (1204); selecting one or more of the representatives (1205); specifying a refined search subset of data items in the search subset within the data categories corresponding to the selected representatives (1207); and repeating the steps of identifying and displaying representatives for the refined search subset.

Abstract: A database searching system, method and controller is provided for interactively searching a database of data items in a descriptor space with a user, comprising a display for viewing by the user; a position selector for manipulation and activation by the user; a reference set selector for selecting a reference set (64a-64d) of two or more data items; a reference set coordinate obtainer for obtaining descriptor coordinates for each of the reference data items; a search results identifier for identifying a search results set of data items in the database which are close to or between one or more members of the reference set in the descriptor space; and a search results display controller for displaying the search results set on the display so that closeness on the display between particular data items is generally indicative of closeness in the descriptor space.

Abstract: A method is provided for a user of a communications device sharing data items with one or more of a plurality of data recipients, comprising the steps of: selecting one or more data items to share (1201); displaying symbols in a two-dimensional geometrical space on a display (1204), at least some of which represent individuals or groups of the data recipients; selecting one or more of the symbols as destinations for the data item(s) (1202); and sharing the data item(s) with the destination (s) (1203).

Abstract: Method, system, and a controller are provided for a selection service recommending or providing access to goods or service items to a consumer. A set of available items is identified, at least some of which require payment to item-providers for access. A measure of likely enjoyment of each available item by the consumer is predicted, and a measure of value for money of each available item for the consumer is calculated. Access to items is provided to the consumer that will represent good value for money.

Abstract: A method, system and controller is provided for a selection service recommending or providing access to goods or service items to a consumer, comprising the steps of: identifying a set of available items at least some of which require payment to item providers for access (1201); predicting a measure of likely enjoyment of each available item by the consumer (1202)/calculating a measure of value for money of each available item for the consumer (1203); and recommending or providing access to items to the consumer that will represent good value for money (1204).

Abstract: A method is provided for a user of a communications device sharing data items with one or more of a plurality of data recipients, comprising the steps of: selecting one or more data items to share (1201); displaying symbols in a two-dimensional geometrical space on a display (1204), at least some of which represent individuals or groups of the data recipients; selecting one or more of the symbols as destinations for the data item(s) (1202); and sharing the data item(s) with the destination (s) (1203).

Abstract: A method, system and controller is provided for searching a database containing data items with a user via a user inter the method comprising the steps of specifying an initial search subset of some or all of the data items in the database (1201); identifying representatives of each of a number of data categories in the search subset (1203); displaying the representatives on the user interface (1204); selecting one or more of the representatives (1205); specifying a refined search subset of data items in the search subset within the data categories corresponding to the selected representatives (1207); and repeating the steps of identifying and displaying representatives for the refined search subset.

Abstract: A database searching system, method and controller is provided for interactively searching a database of data items in a descriptor space with a user, comprising a display for viewing by the user; a position selector for manipulation and activation by the user; a reference set selector for selecting a reference set (64a-64d) of two or more data items; a reference set coordinate obtainer for obtaining descriptor coordinates for each of the reference data items; a search results identifier for identifying a search results set of data items in the database which are close to or between one or more members of the reference set in the descriptor space; and a search results display controller for displaying the search results set on the display so that closeness on the display between particular data items is generally indicative of closeness in the descriptor space.

Abstract: A method, system and controller is provided for navigating a network of options on an interactive display. A navigation pane on a display is defined (1201) and a first set of options is displayed in the navigation pane as divided subregions which may be separated by lines (1202). The options corresponding to the subregions may be identified with text or other meaningful symbols or images. Subregion area may correspond to relative importance of each option. A selector is monitored for activation when a pointer is within one of the subregions (1203). If the selected option is a node the subregion associated with the selected option may be magnified in a zooming motion and the second set of options is displayed in the navigation pane (1204, 1206, 1207).

Abstract: A method, system and controller is provided for a selection service recommending or providing access to goods or service items to a consumer, comprising the steps of: identifying a set of available items at least some of which require payment to item providers for access (1201); predicting a measure of likely enjoyment of each available item by the consumer (1202)/calculating a measure of value for money of each available item for the consumer (1203); and recommending or providing access to items to the consumer that will represent good value for money (1204).