Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: This disclosure relates to improved systems and methods for applying coatings to brake rotors. The systems, methods, and techniques described in this disclosure facilitate application of both pretreatment coatings and protective coatings to brake rotors. Other embodiments are disclosed herein as well.

Abstract: Method of creating shared AR session based on a gesture starts with server receiving observed motion data from first device associated with first user. First device generating observed motion data based on an analysis of data stream comprising images of second user performing a gesture. Second user being associated with second device. Server receiving from second device captured motion data that corresponds to the gesture. Captured motion data being recorded by a sensor included in second device. Server determines whether there is a match between observed motion data from first device and captured motion data from second device. In response to determining that there is the match, server generates shared AR session between first device and second device and causes shared AR session to be displayed by first device and second device. Other embodiments are described herein.

Abstract: Various embodiments are disclosed for providing machine learning routines with peripheral device data to infer driver activity and location. Peripheral device data may be collected on a peripheral device having a machine learning routine executing thereon to infer driver activity and perform improved estimation of driver location. Using driver activity and location estimation, contextually relevant delivery workflow assistance may be automatically provided to a delivery driver or other individual without requiring manual input, thereby improving driver safety and operational efficiency.

Abstract: A technique for providing search results may include determining a first entity type, a second entity type, and a relationship type based on a compositional query. The technique may also include identifying nodes of a knowledge graph corresponding to entity references of the first entity type and entity references of the second entity type. The technique may also include determining from the knowledge graph an attribute value corresponding to the relationship type for each entity reference of the first entity type and for each entity reference of the second entity type. The technique may also include comparing the attribute value of each entity reference of the first entity type with the attribute value of each entity reference of the second entity type. The technique may also include determining one or more resultant entity references from the entity references of the first entity type based on the comparing.

Abstract: In accordance with an embodiment, described herein is a system and method for achieving specific behaviors by intercepting file access calls in a mainframe application rehosted in a mainframe rehosting platform. A custom file handler can include a custom version of each of a plurality of default file operation application program interfaces (APIs) available in the mainframe rehosting platform, and can be invoked by the rehosted mainframe application. Each custom file operation API can perform one of a plurality of specific behaviors comprising changing a file access mode, appending a specific data field at the end of each record or line of a file, and performing one or more special post-handling actions. If the rehosted mainframe application cannot detect the existence of a custom file handler, a file access call can be directed to one or more of the plurality of default file operations APIs.

Abstract: An ocular implant is provided for an intraocular delivery of a therapeutic biologic agent. The implant may be used intracamerally or intravitreally. The implant may include a sustained-release biodegradable core and a biodegradable shell, wherein the shell has a longer biodegradable half-life than the core. The core may include a biodegradable gel medium, an active therapeutic biologic agent, and a biologic stabilizer. Upon insertion into the anterior chamber or vitreous body of an eye, the therapeutic biologic agent is released over an extended period, that may range from one day to one year. The therapeutic biologic agent may be, for example, tissue-plasminogen activator, an anti-VEGF agent, or another biopharmaceutical. The biodegradable implant may completely dissolve after implantation and need not be removed.

Abstract: In accordance with an embodiment, described herein is a system and method for achieving specific behaviors by intercepting file access calls in a mainframe application rehosted in a mainframe rehosting platform. A custom file handler can include a custom version of each of a plurality of default file operation APIs available in the mainframe rehosting platform, and can be invoked by the rehosted mainframe application. Each custom file operation API can perform one of a plurality of specific behaviors comprising changing a file access mode, appending a specific data field at the end of each record or line of a file, and performing one or more special post-handling actions. If the rehosted mainframe application cannot detect the existence of a custom file handler, a file access call can be directed to one or more of the plurality of default file operations APIs.

Abstract: The present invention relates to diacylglycerol acyltransferase genes and proteins, and methods of their use. In particular, the invention describes genes and proteins that exhibit both long-chain acyltransferase and acetyltransferase activity. The present invention encompasses both native and recombinant wild-type forms of the transferase, as well as mutants and variant forms, some of which possess altered characteristics relative to the wild-type transferase. The present invention also relates to methods of using diacylglycerol acyltransferase genes and proteins, including in their expression in transgenic organisms and in the production of acetyl-glycerides in plant oils, and in particular seed oils.

Abstract: An offset printing apparatus having a coated imaging member for use with phase-change inks, has a substrate, an optional intermediate layer, and thereover an outer coating having an elastomer of monomers selected from the group consisting of halogenated monomers, polyorganosiloxane monomers, and mixtures thereof, and an optional heating member associated with the offset printing apparatus

Abstract: A condenser microphone includes: a casing including a peripheral wall that has a top end and a bottom end defining a bottom opening, and a flange that is bent inwardly from the top end of the peripheral wall; a substrate having an inner surface that is attached to the bottom end, that covers the bottom opening, and that cooperates with the peripheral wall and the flange to define an accommodating space thereamong; a diaphragm-and-ring assembly disposed in the accommodating space; a spacer disposed in the accommodating space between the diaphragm-and-ring assembly and the inner surface of the substrate; and a backplate.

Abstract: The present invention relates to diacylglycerol acyltransferase genes and proteins, and methods of their use. In particular, the invention describes genes and proteins that exhibit both long-chain acyltransferase and acetyltransferase activity. The present invention encompasses both native and recombinant wild-type forms of the transferase, as well as mutants and variant forms, some of which possess altered characteristics relative to the wild-type transferase. The present invention also relates to methods of using diacylglycerol acyltransferase genes and proteins, including in their expression in transgenic organisms and in the production of acetyl-glycerides in plant oils, and in particular seed oils.

Abstract: Embodiments use an apparatus comprising a media path that is adapted to transport media sheets within the printing apparatus. Fuser rolls are positioned along the media path, and the fuser rolls are adapted to fuse marking material on the media sheets as the media sheets pass the fuser rolls. A heating belt is positioned to pass a first location between the fuser rolls and to pass a second location separate from the fuser rolls. A heater is positioned in the second location, and the heater is adapted to heat the heating belt. In addition, an iso-thermalizing roller is in contact with the heating belt. In some embodiments, the elements can be positioned in any order. In other embodiments, the elements are positioned such that the heating belt passes the elements in the following order: the heater, the fuser rolls, and then the iso-thermalizing roller.

Abstract: A fusing member is formed from an evacuable inner tube with a cylindrical wall. The evacuable inner tube is inserted into an outer tube and the inner tube is pressurized to expand the inner tube such that the wall is in contact with the outer tube. An amount of a working fluid is then sealed within the inner tube at a below atmospheric pressure.

Abstract: A coated member includes a substrate and a coating layer over the substrate where the coating layer includes at least one of ferromagnetic and magnetic particles dispersed in a binder. The member, which is suitable for use in an electrostatographic printing process, can be in the form of a fuser member, a fixing member, a pressure roller, or a release agent donor member.

Abstract: The present invention relates to diacylglycerol acyltransferase genes and proteins, and methods of their use. In particular, the invention describes genes and proteins that exhibit both long-chain acyltransferase and acetyltransferase activity. The present invention encompasses both native and recombinant wild-type forms of the transferase, as well as mutants and variant forms, some of which possess altered characteristics relative to the wild-type transferase. The present invention also relates to methods of using diacylglycerol acyltransferase genes and proteins, including in their expression in transgenic organisms and in the production of acetyl-glycerides in plant oils, and in particular seed oils.

Abstract: Toners including a low melt wax and a carnauba wax are described. The toners include at least one binder, at least one colorant, at least one wax having a melting point of 135° C. or less, and a compatibilizer wax (e.g., carnauba wax). The low melt wax is preferably polyethylene wax. Images may be formed with the toners in an image forming process including steps of depositing the toner onto a latent image of an imaging member to form a toner image, transferring the toner image to an image receiving substrate, and fusing the toner image. During the fusing, the at least one wax and the compatibilizer wax exude from the toner, forming a stripping enhancing layer upon the toner image. Thus, fuser roll stripping performance is enhanced.

Abstract: An energy transfer device and system includes a heat pipe and an interior coating to at least a portion of an interior surface of the heat pipe, the interior coating comprises at least one of the properties selected from chemically inert, liquid phobic, stable at high temperature, of low porosity and of low surface energy. Moreover, a manufacturing method of an energy transfer device that includes providing a heat pipe and providing an interior coating to an interior surface of at least a portion of the heat pipe, the interior coating comprising at least one of the properties selected from chemically inert, liquid phobic, stable at high temperature, of low porosity and of low surface energy.