Patents by Inventor David Paramelle

David Paramelle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Specific internalization of nanoparticles into protein cages
    Patent number: 10035990
    Abstract: The invention relates to a method to encapsulate nanoparticles into a protein cage by inserting the nanoparticles into the core through holes. Currently commercially available nanoparticles can be functionalized using the inventive method. The inventive hybrids have applications in biosensing and bioimaging. The use of an affinity between poly-histidine chains and nitrilotriacetic acid as chelating reagent to obtain the inventive cages and hybrid assemblies by the method according to the invention is shown in FIG. 1.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: July 31, 2018
    Assignees: Agency for Science, Technology, and Research, Nanyang Technological University
    Inventors: David Paramelle, Nikodem Tomczak, Paul Free, Sierin Lim, Tao Peng
  • SPECIFIC INTERNALIZATION OF NANOPARTICLES INTO PROTEIN CAGES
    Publication number: 20150329836
    Abstract: The invention relates to a method to encapsulate nanoparticles into a protein cage by inserting the nanoparticles into the core through holes. Currently commercially available nanoparticles can be functionalized using the inventive method. The inventive hybrids have applications in biosensing and bioimaging. The use of an affinity between poly-histidine chains and nitrilotriacetic acid as chelating reagent to obtain the inventive cages and hybrid assemblies by the method according to the invention is shown in FIG. 1.
    Type: Application
    Filed: December 10, 2013
    Publication date: November 19, 2015
    Inventors: David Paramelle, Nikodem Tomczak, Paul Free, Sierin Lim, Tao Peng
  • CROSS-LINKING AGENTS
    Publication number: 20120070856
    Abstract: The invention relates to a protein cross-linking agent of the formula, where R1 is an aryl group optionally substituted once or several times by a grouping selected from the group consisting of hydroxy, C1-C4 alkyl, OBoc, SO3Na, Deu, and C1-C4 alkoxy groupings, R2 is N, (III), or (IV), n and in are identical or different integers between 0 and 10, p is an integer between 0 and 5, k is 0, 1, 2 or 3, and X and X? are identical or different and are a reactive function of the proteins. The invention also relates to a method for the structural analysis of a protein or a protein complex.
    Type: Application
    Filed: March 4, 2010
    Publication date: March 22, 2012
    Inventors: Jean Martinez, Gilles Subra, Christine Goubet, David Paramelle, Eric Forest, Michaël Heymann, Christophe Geourjon