Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: A fluid circuit of a heat exchanger includes a core and a first header. The core is configured to receive a fluid and includes a plurality of conduits. Each of the plurality of conduits extends along a longitudinal axis from a first end portion to a second end portion. The first header is integrally formed with and fluidly connecting the plurality of conduits. Outer walls of the plurality of conduits taper outward relative to the longitudinal axes to join the first header.

Abstract: A power module includes a first board comprising a first surface and a second surface opposite to each other and perpendicular to a bottom surface of the power module for mounting the power module to a circuit board, the bottom surface providing electrical connections to the circuit board, a first charge pump assembly mounted on the first surface, the first charge pump assembly comprising a first power conversion circuit configured to convert an input voltage to an output voltage, and a first vertical heatsink structure arranged adjacent to the first charge pump assembly, the first charge pump assembly being placed between the first vertical heatsink structure and the first board.

Abstract: A battery module, in accordance with a non-limiting example, includes a module housing including a plurality of walls defining an interior, and a plurality of battery cells arranged in the interior. Each of the plurality of battery cells includes a vent. A vent manifold is connected to each of the plurality of battery cells. The vent manifold includes a central passage fluidically connected to the vent in each of the plurality of battery cells and a fluid inlet that selectively allows passage of an amount of fluid into select ones of the plurality of battery cells.

Abstract: A regenerative braking controller for an AC motor. To determine an electromagnetic torque for slowing or stopping the motor, the regenerative braking controller accesses a lookup table to retrieve a braking torque value corresponding to a current estimate of rotor velocity. The retrieved braking torque may correspond to a maximum or minimum torque level at which regenerative braking will occur at the current rotor velocity, or to a torque level at which charging current during regenerative braking will be maximized. If an external mechanical brake is present, the regenerative braking controller can forward an external braking torque signal to a controller so that the mechanical brake can apply the remainder of the braking force beyond that indicated by the regenerative braking torque. A method for establishing the braking torques to be stored in the lookup table is also disclosed.

Abstract: A battery module includes a module housing including a plurality of walls defining an interior, an amount of fluid arranged in the interior, and a plurality of battery cells arranged in the interior and at least partially immersed in the amount of fluid. Each of the plurality of battery cells includes a cell can having an interior portion defined by a first wall member, a second wall member arranged opposite the first wall member, a first side wall member, and a second side wall member extending between and connected with the first wall member and the second wall member. The second wall member including a vent. An electrode stack is arranged in the interior portion. The cell can includes a thermally responsive fluid inlet that selectively exposes the interior portion of the cell can to the amount of fluid contained in the interior of the module housing.

Abstract: Systems and methods presented herein include a venue system that includes a guest recognition system configured to recognize one or more guests in a venue, and a guest experience analysis system configured to receive data relating to the recognized one or more guests from the guest recognition system, to generate guest experience information relating to the recognized one or more guests based at least in part on the received data relating to the recognized one or more guests, and to transmit the guest experience information relating to the recognized one or more guests to an augmented reality display device for display on an augmented reality display of the augmented reality display device.

Abstract: Systems and methods for planning a treatment for a patient's teeth are provided. In some embodiments, a method includes receiving input data representing an initial tooth arrangement of a patient's teeth. The method can include determining a target tooth arrangement for the patient's teeth, the target tooth arrangement including a change in mass of at least one tooth. The method can also include generating a plurality of intermediate tooth arrangements configured to adjust the patient's teeth from the initial tooth arrangement toward the target tooth arrangement. The method can further include generating instructions to output a visualization showing a difference in tooth mass between at least one intermediate tooth arrangement of the plurality of intermediate tooth arrangements and the target tooth arrangement.

Abstract: A wellhead bracing system for a subsea well includes a base plate assembly and a wellhead brace assembly. The base plate assembly comprises a top surface, a bottom surface, a base plate aperture, and a plurality of anchor holes. The wellhead brace assembly comprises a vertical plate assembly having a cylindrical shape, a horizontal plate assembly to which the vertical plate assembly is attached, and a vertical support assembly attached to an outer surface of the vertical plate assembly and attached to the top surface of the horizontal plate assembly. Horizontal plate holes of the horizontal plate assembly are configured to attach to studs on the top surface of the base plate to secure the wellhead brace assembly to the base plate assembly. The wellhead bracing system slides onto a wellhead of the subsea well and braces an exterior of the wellhead.

Abstract: The present disclosure provides a sensor cleaning system that cleans one or more sensors of an autonomous vehicle. Each sensor can have one or more corresponding sensor cleaning units that are configured to clean such sensor using a fluid (e.g., a gas or a liquid). Thus, the sensor cleaning system can include both a gas cleaning system and a liquid cleaning system. According to one aspect, the sensor cleaning system can provide individualized cleaning of the autonomous vehicle sensors. According to another aspect, a liquid cleaning system can be pressurized or otherwise powered by the gas cleaning system or other gas system.

Abstract: Systems and methods are described for managing personal data on a client computer, in which personal data associated with the client computer is identified by a policy management module. An analysis may be performed for the client computer by a server using fake personal data. To identify applications which may attempt to access the personal data, the fake personal data is tracked for access on the client computer. A policy is then created that disallows access of the personal data by any applications identified by the analysis of the client computer as accessing the fake personal data. The policy is then assigned to the client computer.

Abstract: An imitation learning system may learn how to play a video game based on user interactions by a tester or other user of the video game. The imitation learning system may develop an imitation learning model based, at least in part, on the tester's interaction with the video game and the corresponding state of the video game to determine or predict actions that may be performed when interacting with the video game. The imitation learning system may use the imitation learning model to control automated agents that can play additional instances of the video game. Further, as the user continues to interact with the video game during testing, the imitation learning model may continue to be updated. Thus, the interactions by the automated agents with the video game may, over time, almost mimic the interaction by the user enabling multiple tests of the video game to be performed simultaneously.

Abstract: A series of pyridinium compounds have a low reduction potential and a highly persistent radical state are generally 2,6-dialkyl-4-arylpyridinum compounds and are utilized as anolytes in redox flow, thin-film metal-organic hybrid and all-organic batteries. Associated routes for synthesizing these pyridinium compounds from pyrylium intermediates are also disclosed.

Abstract: Methods and systems for a semiconductor device package with a die to interposer wafer first bond are disclosed and may include bonding a plurality of semiconductor die comprising electronic devices to an interposer wafer, and applying an underfill material between the die and the interposer wafer. Methods and systems for a semiconductor device package with a die-to-packing substrate first bond are disclosed and may include bonding a first semiconductor die to a packaging substrate, applying an underfill material between the first semiconductor die and the packaging substrate, and bonding one or more additional die to the first semiconductor die. Methods and systems for a semiconductor device package with a die-to-die first bond are disclosed and may include bonding one or more semiconductor die comprising electronic devices to an interposer die.

Abstract: A method and apparatus for processing documents is provided. The documents may be conveyed to a feeder for feeding documents to a scanner. The scanner scans each document to obtain image data and then discharges the document to one or more output or sort locations. The system may include a skew reduction assembly for reducing skew in the documents as the documents are fed to the scanner. The system may also include elements for improving image quality and reducing document damage while the document is scanned. The system may further include features for improving the stacking of the discharged documents.

Abstract: A method and apparatus for processing documents is provided. The documents may be conveyed to a feeder for feeding documents to a scanner. The scanner scans each document to obtain image data and then discharges the document to one or more output or sort locations. The system may include a skew reduction assembly for reducing skew in the documents as the documents are fed to the scanner. The system may also include elements for improving image quality and reducing document damage while the document is scanned. The system may further include features for improving the stacking of the discharged documents.

Abstract: Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: An apparatus and process for steam reforming can be configured to produce at least one product with reduced carbon dioxide and/or nitrogen oxide emissions. Some embodiments can be better adapted for retrofitting a pre-existing steam reforming process while other embodiments can be better adapted for use in a newly constructed facility. Embodiments can be configured to utilize a synthetic air oxidant to provide combustion that results in formation of a flue gas having relatively high carbon dioxide concentrations that may also have low nitrogen and low nitrogen oxide concentrations. A control system can be configured for utilization in such embodiments to control the steam reforming process and/or oxidant formation process as well. Some embodiments can also be configured to provide carbon dioxide recovery that can permit recovery of a second product stream comprised of carbon dioxide.

Abstract: The disclosure provides an approach for cryptographic agility for multi-layer privacy-preserving data aggregation. Embodiments include receiving a request for dynamic cryptographic technique selection related to a data aggregation process involving a first aggregator device and a second aggregator device performing one or more computations on data provided from multiple endpoints. Embodiments include determining, based on contextual information, that the second aggregator device is associated with a confidential computing component and that the first aggregator device is not associated with any confidential computing component. Embodiments include selecting one or more homomorphic encryption techniques for protecting the data while in use by the first aggregator device based on the determining that the first aggregator device is not associated with any confidential computing component and selecting a confidential computing technique for protecting the data while in use by the second aggregator device.

Abstract: Apparatuses including spark gap structures for electrical overstress (EOS) monitoring or protection, and associated methods, are disclosed. In an aspect, a vertical spark gap device includes a substrate having a horizontal main surface and a plurality of pairs of conductive layers over the horizontal main surface. Different ones of the pairs are separated by different vertical distances such that each pair serves as an arcing electrode pair and different ones of the arcing electrode pairs are configured to arc discharge at different voltages.