Patents by Inventor David Paul Provencal

David Paul Provencal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR MAKING (R) -3-(2,3-DIHYDROXYPROPYL)-6-FLUORO-5-(2-FLOURO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-d]PYRIMIDINE-4,7(3H,8H)-DIONE AND INTERMEDIATES THEREOF
    Publication number: 20130225813
    Abstract: The present invention relates generally intermediates for making (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione.
    Type: Application
    Filed: March 20, 2013
    Publication date: August 29, 2013
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventor: David Paul Provencal
  • METHOD OF MAKING AZAINDAZOLE DERIVATIVES
    Publication number: 20130197229
    Abstract: Disclosed are methods, reagents, and intermediates useful for making azaindazole derivatives, which may be used to modulate Glucokinase. The disclosed methods and materials are generally useful for making halo-esters and sulfonyl-substituted compounds.
    Type: Application
    Filed: October 13, 2011
    Publication date: August 1, 2013
    Inventors: Christopher Matthews, Colin O'Bryan, David Paul Provencal
  • Process for making ()-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-flouro-4- iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7()-dione and intermediates thereof
    Patent number: 8436200
    Abstract: The present invention relates generally to processes of making (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, intermediates thereof, and a process for making a particular polymorph of (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: May 7, 2013
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: David Paul Provencal, Yuxin Zhao, Todd Miller, Jonathon S. Salsbury
  • PROCESS FOR MAKING (R) -3-(2,3-DIHYDROXYPROPYL)-6-FLUORO-5-(2-FLOURO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-d]PYRIMIDINE-4,7(3H,8H)-DIONE AND INTERMEDIATES THEREOF
    Publication number: 20120264967
    Abstract: The present invention relates generally to processes of making (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, intermediates thereof, and a process for making a particular polymorph of (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione.
    Type: Application
    Filed: March 15, 2012
    Publication date: October 18, 2012
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: David Paul Provencal, Todd Miller, Yuxin Zhao, Jonathon S. Salsbury
  • PROCESS FOR MAKING (R)-3-(2,3-DIHYDROXYPROPYL)-6-FLUORO-5-(2-FLOURO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-d]PYRIMIDINE-4,7(3H,8H)-DIONE AND INTERMEDIATES THEREOF
    Publication number: 20100125138
    Abstract: The present invention relates generally to processes of making (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, intermediates thereof, and a process for making a particular polymorph of (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione.
    Type: Application
    Filed: November 12, 2009
    Publication date: May 20, 2010
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: David Paul Provencal, Todd Miller, Yuxin Zhao, Jonathon S. Salsbury
  • Neurotrophic bicyclic diamides
    Patent number: 6818643
    Abstract: The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel bicyclic diamide compounds that are neuroprotective and/or neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: November 16, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gene Michael Dubowchik, David Paul Provencal
  • BIS hydrochloride monohydrate salt of RSV fusion inhibitor
    Patent number: 6737428
    Abstract: The novel crystalline bis hydrochloride monohydrate salt having the formula and pharmaceutical dosage forms thereof is provided having use in the treatment of respiratory syncytial viral infection.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: May 18, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Christoph Gesenberg, David Paul Provencal, Srinivasan Venkatesh, Hua Wang
  • Bis hydrochloride monohydrate salt of RSV fusion inhibitor
    Publication number: 20030114481
    Abstract: The novel crystalline bis hydrochloride monohydrate salt having the formula 1
    Type: Application
    Filed: December 5, 2002
    Publication date: June 19, 2003
    Inventors: Christoph Gesenberg, David Paul Provencal, Srinivasan Venkatesh, Hua Wang