Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: There is provided a search system comprising a statistical model trained on text associated with a piece of content. The text associated with the piece of content is drawn from a plurality of different data sources. The system is configured to receive text input and generate using the statistical model an estimate of the likelihood that the piece of content is relevant given the text input. A corresponding method is also provided.

Abstract: There is provided a search system comprising a statistical model trained on text associated with a piece of content. The text associated with the piece of content is drawn from a plurality of different data sources. The system is configured to receive text input and generate using the statistical model an estimate of the likelihood that the piece of content is relevant given the text input. A corresponding method is also provided.

Abstract: A data-storage system comprises a head receiver configured to variably receive up to a number M of write heads. The data-storage system also includes an installed number N of write heads arranged in the head receiver, a substrate receiver configured to receive one or more data-storage substrates, and a positioner machine configured to adjust a relative placement of each of the M write heads with respect to at least one of the one or more data-storage substrates.

Abstract: A data-storage system comprises a head receiver configured to variably receive up to a number M of write heads. The data-storage system also includes an installed number N of write heads arranged in the head receiver, a substrate receiver configured to receive one or more data-storage substrates, and a positioner machine configured to adjust a relative placement of each of the M write heads with respect to at least one of the one or more data-storage substrates.

Abstract: A method to record data in a solid substrate comprises modulating a polarization angle of a coherent optical pulsetrain, and, while the polarization angle is being modulated, focusing the coherent optical pulsetrain on a locus moving through the solid substrate at a relative velocity. Here the relative velocity, a width of the locus in a direction of the relative velocity, and a rate of modulation of the polarization angle are such that the substrate receives within the width of the locus two or more pulses of the optical pulsetrain differing in polarization angle. In this manner, the two or more pulses record, in different portions of the substrate within the width of the locus, two or more different symbols.

Abstract: A data-storage system comprises a head receiver configured to variably receive up to a number M of write heads. The data-storage system also includes an installed number N of write heads arranged in the head receiver, a substrate receiver configured to receive one or more data-storage substrates, and a positioner machine configured to adjust a relative placement of each of the M write heads with respect to at least one of the one or more data-storage substrates.

Abstract: A data-storage system comprises a head receiver configured to variably receive up to a number M of write heads. The data-storage system also includes an installed number N of write heads arranged in the head receiver, a substrate receiver configured to receive one or more data-storage substrates, and a positioner machine configured to adjust a relative placement of each of the M write heads with respect to at least one of the one or more data-storage substrates.

Abstract: There is a communications network node comprising a transmitter or a receiver configured to communicate with a plurality of other nodes via an interconnection medium interconnecting the node and the other nodes. The node is frequency synchronized with regard to signal transmission or reception, via a frequency synchronization mechanism, with at least one of the other nodes. The node has at least one store holding phase data relating to an amount of phase asynchrony and path characteristics between the node and at least one of the other nodes. A phase controller uses the stored data to adjust phase used by the node such that the recovery of data when communicating with at least one other node is facilitated.

Abstract: There is provided a search system comprising a statistical model trained on text associated with a piece of content. The text associated with the piece of content is drawn from a plurality of different data sources. The system is configured to receive text input and generate using the statistical model an estimate of the likelihood that the piece of content is relevant given the text input. A corresponding method is also provided.

Abstract: A system and method for providing speed-regulated data transmission between two synchronous systems in different clock domains. A first synchronous circuit includes a memory device, and a second synchronous circuit includes one or more data-requesting devices. The first synchronous circuit operates at a greater clock speed than the clock speed of the second synchronous circuit. A read request buffer queues read request signals from the data-requesting devices, and outputs one of the read request signals to the memory device. A pulse generator receives the read request signal which was output from the queue, and generates a plurality of signal pulses in response thereto. Each of the pulses occurs at a different predetermined time from the occurrence of the read request signal. One of the pulses is selected to be the read acknowledge signal, and assertion of the read acknowledge signal allows the read request buffer queue to output another read request signal.

Abstract: A system and method for transmitting commands from one or more input/output devices to a memory is provided. An identification tag is appended to each command to define the command as either a read or write command. The read commands are separated from the write commands based on the state of the identification tag, and the read and write commands are separately queued. The read commands are stored in a first command queue, and the write commands are stored in a second, separate, command queue. The read commands in the first command queue are successively transferred to the memory upon completion of the current memory read function, and the write commands in the second command queue are successively transferred to the memory upon completion of the current memory write function. The transfer of the read and write commands is independent.