Abstract: Apparatus and methods for applying a phase-agnostic stimuli are disclosed herein. Certain embodiments include methods and apparatus that are configured to receive a detected signal from a subject and transmit a stimulation signal that is configured to optimize a response signal without regard to the phase of the detected signal.

Abstract: The inventors have developed systems and methods for providing stochastic stimulus to patients to improve their respiration. For instance, the inventors have discovered that ventilated infants improve their breathing including by reducing the total amount of desaturation during periods of stochastic, mechanical stimulation. It was previously thought that stochastic stimulation only improved breathing by encouraging active pacemaker activity. Accordingly, the inventors have developed systems and methods that improves infant respiration.

Abstract: A system is described that observes a signal from a subject of interest, converts the signal to an electrical representation, uses the electrical representation to compute a synthetic control signal, and applies the synthetic control signal to control some aspect of operation of the subject. The procedure used to generate the synthetic control signal involves subjecting the electrical representation of the observed signal to random noise, allowing the extrema of the electrical representation to move, and obtaining a converged solution as the synthetic control signal.

Abstract: Systems and methods are disclosed to monitor physiological for the occurrence of life threatening events and to apply stimulation to prevent the occurrence of said life-threatening events. Systems and methods for applying the stimulation are also disclosed. These systems include applying the stimulation through via a mattress having a passive section and an active section, a plurality of focal stimulators, and/or an array to apply the stimulation are also disclosed. These devices include a mattress with an active region and a passive region, a stimulating array do deliver targeted stimulation, and a plurality of stimulators to apply focused stimulation.

Abstract: Systems and methods according to the present concepts reduce irritability in infants, such as infants suffering from neonatal abstinence syndrome (NAS) or colic. According to one embodiment, a method for reducing irritability in an infant includes determining one or more physiological measurements from an infant. The one or more physiological measurements relate to a state of irritability in the infant. The method also includes determining the state of irritability based on the one or more physiological measurements and applying a stochastic stimulation to the infant based on the state of irritability. The stochastic stimulation may be applied via a mattress. The stochastic stimulation may be vibro-tactile or subsensory.

Abstract: A system is described that observes a signal from a subject of interest, converts the signal to an electrical representation, uses the electrical representation to compute a synthetic control signal, and applies the synthetic control signal to control some aspect of operation of the subject. The procedure used to generate the synthetic control signal involves subjecting the electrical representation of the observed signal to random noise, allowing the extrema of the electrical representation to move, and obtaining a converged solution as the synthetic control signal.

Abstract: Systems and methods according to the present concepts reduce irritability in infants, such as infants suffering from neonatal abstinence syndrome (NAS) or colic. According to one embodiment, a method for reducing irritability in an infant includes determining one or more physiological measurements from an infant. The one or more physiological measurements relate to a state of irritability in the infant. The method also includes determining the state of irritability based on the one or more physiological measurements and applying a stochastic stimulation to the infant based on the state of irritability. The stochastic stimulation may be applied via a mattress. The stochastic stimulation may be vibro-tactile or subsensory.

Abstract: Systems and methods for inhibiting an occurrence of an apneic or hypoxic event are disclosed. Physiological data is received from a subject and analyzed to detect an impending apneic event or an impending hypoxic event. A stimulation is applied to the subject to inhibit occurrence of the impending apneic or hypoxic event after an occurrence of a predetermined condition. The physiological data can include respiratory data, cardiological data, or a combination thereof. The analyzing includes use of a point-process model and gross body movement data of the subject. Therapeutic effectiveness of the stimulation is increased by accounting for gross body movements of the patient.

Abstract: Systems and methods are disclosed to monitor physiological for the occurrence of life threatening events and to apply stimulation to prevent the occurrence of said life-threatening events. Systems and methods for applying the stimulation are also disclosed. These systems include applying the stimulation through via a mattress having a passive section and an active section, a plurality of focal stimulators, and/or an array to apply the stimulation are also disclosed. These devices include a mattress with an active region and a passive region, a stimulating array do deliver targeted stimulation, and a plurality of stimulators to apply focused stimulation.