Abstract: Provided are methods for treatment of cancer by administering to an individual who has a cancer that includes cancer cells that have an LKBI mutation an anti-CD38 agent, an inhibitor of EP300, or a combination thereof. Methods are also provided for treating an individual who has a cancer that includes cancer cells that do not have an LKBI mutation a Salt-Inducible Kinase (SIK) inhibitor and an anti-CD38 agent. The SIK inhibitors sensitizes the cancer cells that do not have the LKBI mutation to the anti-CD38 agent.

Abstract: Provided are methods of sensitizing LKB1/STK11 deficient cancers to immune therapy. A method for treatment for LKB1/STK11 deficient cancers is provided comprising administration of inhibitor or inhibitors of one or more of NAMPT, CD38, SHP2, CXCR1/2, HDAC4 and PARP in combination with immunotherapy.

Abstract: Systems and methods are provided for filtering atmospheric conditions from LiDAR point clouds. The method includes generating, using a LiDAR system, at least one point cloud, wherein the LiDAR system includes a processor. The method further includes, using the processor, identifying and isolating one or more ground points within a point cloud of the at least one point cloud, wherein the one or more ground points indicate a ground portion within an environment of the point cloud, filtering out the ground portion from the point cloud, generating an initial processed point cloud, identifying and isolating one or more atmospheric condition points within the initial processed point cloud, wherein the one or more atmospheric condition points indicate one or more atmospheric conditions within an environment of the processed point cloud, and filtering out the atmospheric condition points from the initial processed point cloud, generating a final processed point cloud.

Abstract: An apparatus for modifying an electrical circuit includes a first electrical contact, a second electrical contact, an electrical coupler formed of an electrically conductive material, a first assembly including a cavity, a driving portion, an inhibiting portion, and a second assembly electrically coupled to the second electrical contact. The electrical coupler is moveable within the cavity along a movement axis, a wall of the cavity is electrically coupled to the first electrical contact and to the electrical coupler, and when the electrical coupler is disposed at an initial position within the cavity, the electrical coupler is not electrically coupled to the second electrical contact. The driving portion applies a first force on the electrical coupler in a movement direction along the movement axis. The inhibiting portion inhibits the movement of the electrical coupler along the movement axis.

Abstract: Provided are methods of sensitizing LKB1/STK11 deficient cancers to immune therapy. A method for treatment for LKB1/STK11 deficient cancers is provided comprising administration of inhibitor or inhibitors of one or more of NAMPT, CD38, SHP2, CXCR1/2, HDAC4 and PARP in combination with immunotherapy.

Abstract: An apparatus for modifying an electrical circuit includes a first electrical contact, a second electrical contact, an electrical coupler formed of an electrically conductive material, a first assembly including a cavity, a driving portion, an inhibiting portion, and a second assembly electrically coupled to the second electrical contact. The electrical coupler is moveable within the cavity along a movement axis, a wall of the cavity is electrically coupled to the first electrical contact and to the electrical coupler, and when the electrical coupler is disposed at an initial position within the cavity, the electrical coupler is not electrically coupled to the second electrical contact. The driving portion applies a first force on the electrical coupler in a movement direction along the movement axis. The inhibiting portion inhibits the movement of the electrical coupler along the movement axis.

Abstract: A hermetically sealed package has an electrically insulating substrate, a plurality of electrically and thermally conductive tabs, and a lid. The electrically insulating substrate has a plurality of apertures and an aspect ratio of about 10:1 or greater. The plurality of electrically and thermally conductive tabs is hermetically joined to a bottom surface of the electrically insulating substrate and at least one tab covers each of the apertures. The lid is hermetically joined to a top surface of the electrically insulating substrate proximate to a perimeter of the electrically insulating substrate.

Abstract: A hermetically sealed package has an electrically insulating substrate, a plurality of electrically and thermally conductive tabs, and a lid. The electrically insulating substrate has a plurality of apertures and an aspect ratio of about 10:1 or greater. The plurality of electrically and thermally conductive tabs is hermetically joined to a bottom surface of the electrically insulating substrate and at least one tab covers each of the apertures. The lid is hermetically joined to a top surface of the electrically insulating substrate proximate to a perimeter of the electrically insulating substrate.

Abstract: Systems, apparatus, and methods of monitoring and reducing snore are discussed herein. Some embodiments may provide for a system including a snore detection module, a movement detection module, a control module, and an actuation module. The snore detection module may be configured to detect snore, such as by detecting vibrations caused by snoring. When snoring is detected, the control module may be configured to instruct the actuation module to apply stimulation to the user that is calibrated to cause the user to shift sleeping position without disturbing sleep. The movement detection module may be configured to monitor user movement. If the user fails to move in response to the actuation, the actuation module may increase the intensity of the actuation. If the user responds to the actuation, the process may be repeated after a predetermined delay to provide continuous snore monitoring and correction throughout user sleep.

Abstract: A linear voltage regulator includes a Miller frequency compensation having a movable zero, which tracks the frequency of the load pole as the load condition changes. The compensated voltage regulator maintains stability under variable load conditions. Because of the Miller effect, DC open-loop gain and bandwidth are not sacrificed for stability. The compensated voltage regulator can therefore maintain high power supply rejection ratio (PSRR).

Abstract: A simplified bi-annular-shaped bearing with anti-play characteristics has an inner race, an outer race, at least one ring groove and a roller-shaped limiting set, The races can relatively rotate. The ring groove is configured on the periphery of the inner race or the inner ring surface of the outer race. The roller-shaped limiting set is configured on at least one position of the outer race or inner race, and comprises rigid balls, elastic supporting components and positioning members. The outer race or inner race is configured with a radial housing part to hold the roller-shaped limiting set. The elastic supporting component is to elastically push the rigid ball toward the end opening configured on the radial housing part, so that it will go into and contact against the ring groove.

Abstract: A SIC mechanical seal including a main body made of SIC materials. The main body includes a fixing portion and a pushed surface. The seal also includes a retainer including a shaft coupling seat, a push ring and an elastic part; of which the push ring is made of SIC material, and provided with a ring surface that's riveted to the pushed surface of the main body. The seal also includes at least an area of lower friction, set globally or locally onto either the pushed surface of the main body or the ring surface of the push ring. The friction of this area is less than that of the main body and the push ring. The area of lower friction is of a composite layer which is made of a mixture of SIC and carbon materials, or composed of multiple dents arranged at interval.

Abstract: A linear voltage regulator includes a Miller frequency compensation having a movable zero, which tracks the frequency of the load pole as the load condition changes. The compensated voltage regulator maintains stability under variable load conditions. Because of the Miller effect, DC open-loop gain and bandwidth are not sacrificed for stability. The compensated voltage regulator can therefore maintain high power supply rejection ratio (PSRR).

Abstract: A method for purifying proteins by Protein A chromatography is described which comprises removing contaminants by washing the solid phase with various intermediate wash buffers.

Abstract: A method for purifying proteins by Protein A chromatography is described which comprises removing contaminants by washing the solid phase with various intermediate wash buffers.

Abstract: A business card reader includes a scanning module, a USB detecting/switching unit and two USB ports. The business card reader is connected to at least one of a personal computer and a PDA through the two USB ports, respectively. The USB detecting/switching unit controls the data transmission path among the scanning module, the personal computer and the PDA. The business card reader has a socket electrically connected to an external power source for charging a PDA connected to one USB port.