Abstract: Systems, methods, and devices for securing a spinal rod are provided. A clamp assembly comprises a tulip comprising an opening comprising an inner surface, wherein the inner surface is threaded; and a threaded locking cap disposed in the opening, wherein threads of the locking cap and the inner surface include various geometries.

Abstract: Systems, methods, and devices for securing a spinal rod are provided. A clamp assembly comprises a tulip comprising an opening comprising an inner surface, wherein the inner surface is threaded; and a threaded locking cap disposed in the opening, wherein threads of the locking cap and the inner surface include various geometries.

Abstract: Systems, methods, and devices for securing a spinal rod are provided. A clamp assembly may include a tulip comprising a first opening and a second opening, wherein an inner surface of the first opening comprises threads; a saddle movably disposed within the tulip between the first and second openings, the saddle comprising a first end and a second end, the first end comprising a portion configured to receive a spinal rod, the second end comprising a cavity configured to receive a pedicle screw, the saddle comprising slots configured to receive a rotating tool; and a threaded locking cap disposed in the first opening.

Abstract: Orthopedic fixation devices, assemblies, and methods for securing a spinal rod. The orthopedic fixation device may include a tulip head, a bone fastener, a rotatable saddle, and a threaded locking cap. The saddle may be insertable into the tulip head in an unlocked position with a rod seat offset relative to a rod slot of the tulip head. The saddle may be rotated into a locked position with the rod seat aligned with the rod slot such that a rod is positionable through the rod slot and into the rod seat. The threaded locking cap may secure the rod and bone fastener.

Abstract: Orthopedic fixation devices, assemblies, and methods for securing a spinal rod. The orthopedic fixation device may include a tulip head, a bone fastener, a rotatable saddle, and a threaded locking cap. The saddle may be insertable into the tulip head in an unlocked position with a rod seat offset relative to a rod slot of the tulip head. The saddle may be rotated into a locked position with the rod seat aligned with the rod slot such that a rod is positionable through the rod slot and into the rod seat. The threaded locking cap may secure the rod and bone fastener.

Abstract: Systems, methods, and devices for securing a spinal rod are provided. A clamp assembly comprises a tulip comprising an opening comprising an inner surface, wherein the inner surface is threaded; and a threaded locking cap disposed in the opening, wherein threads of the locking cap and the inner surface include various geometries.

Abstract: Systems, methods, and devices for securing a spinal rod are provided. A clamp assembly may include a tulip comprising a first opening and a second opening, wherein an inner surface of the first opening comprises threads; a saddle movably disposed within the tulip between the first and second openings, the saddle comprising a first end and a second end, the first end comprising a portion configured to receive a spinal rod, the second end comprising a cavity configured to receive a pedicle screw, the saddle comprising slots configured to receive a rotating tool; and a threaded locking cap disposed in the first opening.

Abstract: The present invention relates generally to a prosthetic spinal disc for replacing a damaged disc between two vertebrae of a spine and methods for inserting said discs. The intervertebral prosthetic discs are provided with connections for facilitating implantation and removal and features which enhance primary and secondary stability over time.

Abstract: The present disclosure provides methods and kits for detecting analytes using avidin-biotin assays.

Abstract: The present invention relates generally to a prosthetic spinal disc for replacing a damaged disc between two vertebrae of a spine and methods for inserting said discs. The intervertebral prosthetic discs are provided with connections for facilitating implantation and removal and features which enhance primary and secondary stability over time.

Abstract: Orthopedic fixation devices and methods of installing the same. The orthopedic fixation device may include a coupling element and a bone fastener, whereby the bone fastener can be loaded into the coupling element through the bottom of a bore in the coupling element.

Abstract: The present invention relates generally to a prosthetic spinal disc for replacing a damaged disc between two vertebrae of a spine and methods for inserting said discs. The intervertebral prosthetic discs are provided with connections for facilitating implantation and removal and features which enhance primary and secondary stability over time.

Abstract: The present invention relates generally to a prosthetic spinal disc for replacing a damaged disc between two vertebrae of a spine and methods for inserting said discs. The intervertebral prosthetic discs are provided with connections for facilitating implantation and removal and features which enhance primary and secondary stability over time.

Abstract: The present invention relates generally to a prosthetic spinal disc for replacing a damaged disc between two vertebrae of a spine and methods for inserting said discs. The intervertebral prosthetic discs are provided with connections for facilitating implantation and removal and features which enhance primary and secondary stability over time.

Abstract: The present disclosure provides methods and kits for detecting analytes using avidin-biotin assays.

Abstract: The present invention relates generally to a prosthetic spinal disc for replacing a damaged disc between two vertebrae of a spine and methods for inserting said discs. The intervertebral prosthetic discs are provided with connections for facilitating implantation and removal and features which enhance primary and secondary stability over time.

Abstract: A pool heating system is disclosed. The pool heating system includes, in some embodiments, an immersed condenser coil. In some embodiments, the immersed condenser coil is immersed in a pool of water receiving hot refrigerant gas at high pressure from an outdoor unit, transferring heat to water in the pool, condensing the gas and transmitting condensed refrigerant to the outdoor unit. The system also includes an outdoor unit. In some embodiments, the outdoor unit includes a compressor, an expansion valve, an evaporator, and a fan.

Abstract: The invention provides methods for assessing increased probability of having Alzheimer's disease in a subject under assessment including a step of obtaining a measurement of A?40 aggregates in a biological sample from the subject, where the biological sample does not include brain tissue, a fraction of brain tissue, or brain homogenate. In some embodiments, the invention relates to methods of assessing increased probability of early stage Alzheimer's disease. The invention further provides methods of assessing increased probability of not having Alzheimer's disease, methods of monitoring disease progression in a subject with Alzheimer's disease, and methods of assigning disease stage for a subject with Alzheimer's disease, and methods of assessing increased probability of MCI progressing to Alzheimer's disease.

Abstract: The invention provides methods for detecting the presence of an aggregate in a sample by contacting the sample suspected of containing an aggregate with an aggregate-specific binding reagent under conditions that allow the binding of the reagent to the aggregate, if present; and detecting the presence of the aggregate, if any, in the sample by its binding to the reagent; where the aggregate-specific binding reagent typically has a net charge of at least about positive one at the pH at which the sample is contacted with the ASB reagent, is attached to a solid support at a charge density of at least about 60 nmol net charge per square meter, and binds preferentially with aggregates over monomers when attached to the solid support. Methods for detecting the presence of oligomer are also provided. Compositions for use in the methods are provided.

Abstract: One embodiment of the present invention relates to a semi-automated apparatus for vending granular materials in a container comprising a cabinet with a carousel capable of rotating and housing at least one dispensing container. Each dispensing container is adapted to hold granular material and in one embodiment includes a pressure actuated valve. A pneumatic system is coupled to each of the dispensing containers. A motor is coupled to the carousel. The apparatus further comprises a loading station adapted to hold the container, a control system and a user control panel having at least one user interface for controlling operation of the vending machine. The control system, coupled to the motor, the pneumatic system and the user control panel, engages the motor, causing the carousel to rotate, and the pneumatic system, pressurizing the selected dispensing container causing a predetermined amount of granular material to dispense into the vending container.