Abstract: The present disclosure is directed to compositions and methods for modulating autophagy for treatment and prevention of autophagy-associated diseases, disorders, or conditions. Methods include administering a pharmaceutical composition comprising an autophagy modulating agent selected from formulas as defined herein.

Abstract: A transfer device and associated method for transferring at least one file stored on a programming device to a remote platform. The programming device is configured to generate at least one file from data received from a medical device. The transfer device streamlines the process of transferring files from a programming device to a remote platform.

Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods for modulating autophagy for treatment and prevention of autophagy-associated diseases, disorders, or conditions and compositions of photoreactive compounds. An aspect of the present disclosure provides for autophagy enhancing agents capable of treating or preventing diseases, disorders, or conditions in which autophagy is implicated.

Abstract: A computer-implemented method for predicting an evolution of at least one heart-related condition of a patient, the method including, for each heart-related condition: a) based on a set of inputs, at least part of the set of inputs being representative of a temporal evolution of a corresponding health variable among a predetermined set of health variables of the patient, computing a set of transformed variables, the set of transformed variables being a representation of the set of inputs in a predetermined latent data representation space; and b) determining, based on the computed set of transformed variables, at least one index value, each representative of a respective risk of an unfavorable outcome of the heart-related condition.

Abstract: A computer-implemented method for managing information relating to at least one patient with an active implantable medical device (AIMD), including per patient: receiving at least one manufacturer information representative of an output of the respective AIMD over time; analyzing the received manufacturer information based on at least one first type rule, each first type rule being associated to a predefined first sensor event and to at least one patient's clinical information relating to a patient medical status, the analyzing including applying each first type rule to the received manufacturer information in order to determine, depending on each corresponding patient's clinical information of the patient, whether the corresponding predefined first sensor event has occurred and is relevant for diagnosis; labeling the manufacturer information based on a result of the analyzing; outputting data representative of the labeled manufacturer information for diagnosis taking account of the predefined first sensor ev

Abstract: The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents.

Abstract: A method and a system for analyzing electrocardiographic segments previously derived from a cardiac device so as to help to discriminate true positives episodes, including abnormal heart rhythms, from false positives episodes, including normal heart rhythms. Each episode received includes at least one segment of electrocardiographic signal, and each segment is segmented into sub-segments. Score vectors are obtained for each sub-segment to classify the episode so as to discriminate true positive episodes from false positive episodes, and the classification results, which include at least the true positive episodes, are output.

Abstract: A method and a system for analyzing electrocardiographic segments previously derived from a cardiac device so as to help to discriminate true positives episodes, including abnormal heart rhythms, from false positives episodes, including normal heart rhythms. Each episode received includes at least one segment of electrocardiographic signal, and each segment is segmented into sub-segments. Score vectors are obtained for each sub-segment to classify the episode so as to discriminate true positive episodes from false positive episodes, and the classification results, which include at least the true positive episodes, are output.

Abstract: The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents.

Abstract: A multiprocessor computer system which maintains cache coherency includes first and second microprocessors each having an associated cache memory storing lines of data. Each line of data has associated protocol bits that indicate a protocol state consistent with write-through, write-back, or write-once cache coherency policies that are selected via a protocol selection terminal for different system configurations. In one configuration, the output and external address terminals of the first microprocessor are coupled to the external and output address terminals, respectively, of the second microprocessor. This configuration enables each microprocessor to snoop memory cycles to main memory initiated by the other microprocessor so that it can be readily determined if a particular cache has the latest version of data.

Abstract: A pipeline instruction processor for executing instructions stored in an instruction memory, including a plurality of branch instructions. The instruction processor includes a branch target buffer which contains target instructions and target addresses corresponding to branch instructions. The target instruction data is indexed according to the address of the instruction which precedes the branch instruction. Also included in the branch target buffer is history data indicating whether the branch was taken. The instruction processor also includes two execution units. The present invention employs logic which allows a branch instruction and its target instruction stored in the branch target buffer to be executed concurrently in the two execution units according to the history data stored in the branch target buffer. Since the branch instructions and their target instructions are executed during the same cycle, branch instructions appear to be executed in zero cycles.

Abstract: A device for a resonant microwave cavity which includes a tuning plunger assembly to make the resonant frequency less temperature sensitive. The frequency response of a cavity filter, determined by its resonant frequency, primarily depends on the dimensions of the filter cavity. Since cavity dimensions will vary with changes in ambient temperature, some form of compensation is necessary to stabilize the frequency response. The tuning plunger assembly is comprised of a sandwich of materials having substantially different coefficients of expansion. One of the materials, a potting compound with a high coefficient of thermal expansion, acts as an operator to vary the configuration of the plunger assembly in order to maintain the resonant frequency of the cavity substantially fixed.

Abstract: A tester for a solid state voltage regulator includes two parallel branches available for interconnection to the two output contacts of the voltage regulator. The two branches both interconnect to the high voltage side of a battery. One of the branches includes a resistor in parallel combination with an indicator bulb. One of the branches includes a normally open switch. For use with automobile alternators having a built-in regulator, the tester can be connected directly to the regulator and test both the regulator and the alternator. When the regulator is independent of the alternator, it can be tested by itself by using actual rotor current available from an alternator used in conjunction with the tester. The on/off condition of the indicator bulb, when the switch and various contact terminals are interconnected, provides an indication of the effective operation of the regulator. A volt meter can be included integrally with the tester to provide output readings of the regulator.