Abstract: The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.

Abstract: This disclosure relates to novel compounds comprising a zwitterionic trifluoroborate prosthetic group which target prostate-specific membrane antigen (PSMA), e.g. in prostate cancer. The compounds have Formula I, wherein each R1 is an anionic group, L is a linker and R2B-F3 is —N(R3)2CH2BF3, a pyridinium group substituted with BF3 or methyl BF3, or an azole group substituted with methyl BF3. Methods and uses of imaging and treating PSMA-expressing cancers are also disclosed.

Abstract: The aspects herein relate to the field of fall prevention systems, and more specifically to fall arrest systems for storage bins and more particularly to grain bins or silos. In one aspect, a fall prevention system for a ladder may have an anchor plate coupled to a roof. In another aspect, the fall prevention system for the ladder may have an anchor bar coupled to at least a portion of the ladder. A rope is coupled at one end to the anchor plate or bar and at the other end to at least one rung of the ladder using a fastener. A rope grab is slidably coupled to the rope between the anchor plate or bar and the fastener.

Abstract: Fluoridated organofluoroborates comprising at least one 18F atom and precursors thereto, for use in PET scanning.

Abstract: Fluoridated organofluoroborates comprising at least one 18F atom and precursors thereto, for use in PET scanning.

Abstract: The present invention relates to combinations of a H3 antagonist and an antidepressant, which exhibit a synergistic wake promoting activity.

Abstract: A device for a sanitary facility, intended for rapidly delivering Domestic Hot Water (DHW) to the supply points without wasting energy. The device according to the invention transfers the DHW rapidly from the source to the user as soon as there is a need for it. The method, which prevents any recirculation, makes it possible, in particular, to save the large amount of energy that is systematically wasted each time the DHW is distributed between its source and the supply points. The device essentially consists of a motorised, relatively powerful pump (2) which channels the DHW from the source (1) and injects it into a pipe with a very small cross-section (3) that conveys the entire flow rate required by the user at a high velocity to the supply point (41). An adapted sensor (5) controls the switching on and off of the motor pump (2) upon each use and controls its flow rate on the basis of the requirements. A single device can be used for supplying multiple supply points.

Abstract: A slow feeder includes a container for, in use, containing food for an animal. The container has a side wall through which a slot (26) is defined; and a feeding restrictor (6). The feeding restrictor (6) comprises a food-covering element through which at least one opening is defined for, in use, resting on top of the food such that the animal can access the food through the opening; a locating element which extends from the food-covering element through the slot; and a retaining element (34) extending from the locating element and movably engageable with an outer portion of the container. The engagement of the retaining element (34) with the outer portion of the container retains the restrictor (6) in the container.

Abstract: The method of assisting the production of an implantable unfurlable made to measure device comprises: three-dimensional reconstruction of a complex surface of the cavity in which the device will be implanted; Production of a first finite element mesh of this complex surface; Choosing of generic components of the device; Production of a second finite element mesh of these assembled generic components; Determination of the morphosis parameters for morphosing from the first mesh to a mesh of a set of simple linked volumes which is representative of the part of the cavity, and then deformation of the first mesh by this morphosis; Simulation of a deformation of the second mesh, by inverse morphosis dependent on the determined parameters, to the complex surface, simulating unfurling of the device; Determination of dimensioning of points of interest by projection onto the second deformed mesh; and Generation of a production blueprint plan of the device.

Abstract: The present invention concerns a novel combination of adrenalin with an antidepressant and its use as a pharmaceutical composition for the treatment of shocks. A method is also provided for treating a subject in need thereof by administering the combination of adrenaline with an antidepressant. The pharmaceutical composition is to be administered by injection.

Abstract: This disclosure relates to novel compounds comprising a zwitterionic trifluoroborate prosthetic group which target prostate-specific membrane antigen (PSMA), e.g. in prostate cancer. The compounds have Formula I, wherein each R1 is an anionic group, L is a linker and R2B-F3 is —N(R3)2CH2BF3, a pyridinium group substituted with BF3 or methyl BF3, or an azole group substituted with methyl BF3. Methods and uses of imaging and treating PSMA-expressing cancers are also disclosed.

Abstract: Somatostatin derivative compounds of general formula (I) that may be readily labelled with the isotope fluorine-18 and that have affinity and selectivity for cellular somatostatin receptors are provided. The labelled compounds are useful clinically as radioactive tracers in various in vivo imaging applications (for example, using positron emission tomography (PET) and related techniques) to detect somatostatin-expressing cells and tissues, including tumors, or as therapeutic agents.

Abstract: Somatostatin derivative compounds of general formula (I) that may be readily labelled with the isotope fluorine-18 and that have affinity and selectivity for cellular somatostatin receptors are provided. The labelled compounds are useful clinically as radioactive tracers in various in vivo imaging applications (for example, using positron emission tomography (PET) and related techniques) to detect somatostatin-expressing cells and tissues, including tumours, or as therapeutic agents.

Abstract: Fluoridated organofluoroborates comprising at least one 18F atom and precursors thereto, for use in PET scanning.

Abstract: The present invention concerns a novel combination of adrenalin with an antidepressant and its use as a pharmaceutical composition for the treatment of shocks. The pharmaceutical composition is to be administered by injection.

Abstract: A welding system component includes a circuit board for the welding system component. An interface has a main riser portion with a fastener passageway formed therethrough. The interface has an extension portion with a terminal passageway formed therethrough. The extension portion is electrically connected to the circuit board with a terminal disposed in the terminal passageway. The extension portion is spaced away from a surface of the circuit board. A capacitor is electrically connected to the main riser portion with a fastener disposed in the fastener passageway.

Abstract: The invention relates to a width-adjusting device for conveyor corridor(s), comprising a wide gear-reduction mechanism connected to the frame (5) of said conveyor, wherein said mechanism is arranged between the control shaft (12) and the wall(s) of said corridor. The device includes: a final drive capable of reverse operation and consisting of said control shaft (12) in the form of an endless screw and of a toothed wheel (11); and a system for controlling at least one of the walls of said corridor, consisting of an endless screw (13) and a nut, the endless screw being mobile or fixed relative to said toothed wheel (11). The shaft (12) of the final drive is a flexible shaft having a long length and engaging with the tension-retaining system (20) for absorbing the pulling and pushing forces in the rotation direction thereof.

Abstract: The conveyor installation makes it possible to control the speed of items of the bottle (1) type dispatched in several trains distributed across various paths in the form of single-file lanes (11). The lanes are delimited by a pair of walls (16, 17) which are arranged in an omega shape over a base plate made up of several juxtaposed conveyors (13, 14, 15). Each lane (11) may comprise a fixed wall (16) acting as a reference, and a moving wall (17) that can be adjusted according to the dimensions of the items that are to be conveyed.

Abstract: A toy is provided that has a dynamo for converting manual movement into an electrical charge for the dynamo located within a housing. A miniature vehicle is induced to locomote through receipt of the electrical charge. A dock is provided for selectively creating an electrical coupling of the vehicle to the dynamo to transfer the electrical charge and decoupling to allow the vehicle to locomote. A charge storage device and an electrical motor in the vehicle allow for prolonged vehicle locomotion separate from the charge transfer by the dynamo. A toy is also provided that has a dynamo for converting manual movement into an electrical charge, the dynamo located within a housing. The dynamo transfers an electrical charge to a wheeled miniature vehicle through an electrically conductive circuit about which the vehicle travels. Additional amusement functions of LED light output or speaker auditory output are optionally provided.

Abstract: A welding system component includes a circuit board for the welding system component. An interface has a main riser portion with a fastener passageway formed therethrough. The interface has an extension portion with a terminal passageway formed therethrough. The extension portion is electrically connected to the circuit board with a terminal disposed in the terminal passageway. The extension portion is spaced away from a surface of the circuit board. A capacitor is electrically connected to the main riser portion with a fastener disposed in the fastener passageway.