Abstract: Methods of producing multiple protein products from blood-based materials including alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins are described herein. The inventive methods include steps of: salt fractionation, chromatography, ultrafiltration, diafiltration, solvent-detergent treatment, and sterile filtration. Advantageously, the inventive methods are simple and produce alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins in high yields. The sequence of process steps can be selected to obtain multiple products from various in-process materials, such as supernatants, pastes, chromatography flow-though, and chromatography washes.

Abstract: A host device is configured to receive a pluggable optical module, and the host device includes circuitry configured to perform steps of, subsequent to insertion of the pluggable optical module into the host device and prior to the pluggable optical module being fully booted, wherein the pluggable optical module includes a plurality of registers, reading from or writing to one or more registers of the plurality of registers; and, responsive to the pluggable optical module being fully booted, operating the pluggable optical module including reading from or writing to any of the plurality of registers.

Abstract: There is provided a system operable to collect, from a customer, a response to a question relating to a transaction, the system comprising: a requesting device configured to send, to a questions server, data relating to the transaction and a request for a question; the questions server, comprising: a processor; one or more databases storing questions; and a rules engine, the questions server configured to: receive the data relating to the transaction and the request for a question from the requesting device; select a question from the stored questions based on the transaction data; and send the selected question to the requesting device; wherein the requesting device is further configured to: present the question to the customer or instruct a display device to present the question to a customer; wherein the system is further configured to: receive a response to the question; and send data related to the response to the questions server or a response database.

Abstract: Disclosed herein are embodiments of a wound treatment apparatus with electronic components integrated within a wound dressing. In some embodiments, a wound dressing apparatus can comprise a wound contact layer, an absorbent layer over the wound contact layer, the absorbent layer comprising one or more apertures, a cover layer configured to cover and form a seal over the wound contact layer and the absorbent layer, and an electronics assembly comprising a negative pressure source. A portion of the cover layer overlying the one or more apertures in the absorbent layer can be configured to be compressed within the aperture in the absorbent layer when negative pressure is applied to the wound dressing apparatus. The compressed cover layer can indicate a level of negative pressure below the cover layer. In some embodiments, the wound dressing apparatus can comprise an indicator material layer and a cover layer configured to cover and form a seal over the wound contact layer and the indicator material layer.

Abstract: In embodiments, a wearable medical system (WMS) for an ambulatory patient, which can be a wearable cardioverter defibrillator (WCD) system, analyzes the patient's ECG signal to generate a detection outcome. The WMS also has an ambulatory user interface that outputs a human-visible indication. A programming device, such as a PC, a tablet, etc., establishes a communication link with the WMS during an in-person session with the patient. The programming device may include a programming screen that reproduces the human-visible indication in real time. An advantage can be that the person programming the WMS need not strain to look also at the ambulatory user interface at the time they are looking at the programming device. Another advantage can be that the patient will recognize that he or she is better protected, and have their confidence in the WMS increased, and therefore better comply with wearing the WMS as required.

Abstract: A supportive clothing article for a wearable cardioverter defibrillator (WCD), including a belt, the belt including a first end with a first portion of a fastener and a second end with a second portion of the fastener, wherein the belt is structured to fasten around the torso of patient below the chest area of the patient, the belt including a first conductive mesh portion adjacent the first end of the belt or the second end of the belt, two straps, a back portion extending from the belt at an intermediary position on the belt to each of the two straps, the back portion including a conductive mesh, a first support receptacle attached to and extending from the belt and attachable to one of the two straps, and a second support receptacle attached to and extending from the belt and attachable to the other of the two straps.

Abstract: Methods, devices and kits for sampling, releasing and stabilizing nucleic acid, including RNA and DNA, from virus, bacteria yeast and other cells is described. The released and stabilized nucleic acid may be analyzed and quantified without further sample preparation at the point of care or may be transported to a testing laboratory by shipment and analyzed directly. The nucleic acid, which can be RNA, remains safe and stable so that shipping by normal means including government postal service may be used. In addition, the RNA sample remains stable so that analysis can be performed immediately after receipt of sample or after storage for days, weeks or months. Storage may be at room or ambient temperature or cooler temperatures. The sampling apparatus used to acquire samples can interface with nucleic detection and measurement instrumentation including high throughput, parallel processing instruments.

Abstract: A locking cam for securing suspension components in a vehicle. The locking cam has at least one surface that is textured to create a surface for engagement against and with a frame member upon tightening of the suspension components. The textured surface can have ridges or projects for engagement with the frame member.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to determine memory access integrity based on feedback from memory. An example apparatus includes an access reconstruction controller including an output, a first input configured to be coupled to memory, and a second input configured to be coupled to a memory signal generator; a comparator including a first input coupled to the output of the access reconstruction controller, a second input configured to be coupled to an arbiter, and an output configured to be coupled to the arbiter; and a data integrity monitor including an input coupled to the second input of the comparator and configured to be coupled to the arbiter and an output coupled to the output of the comparator and configured to be coupled to the arbiter.

Abstract: Systems, methods, and articles of manufacture provide for community video slot-style gaming such as slot-style games that include a community gaming field and that permit individual players or groups of players to initiate gameplay based on selections of one or more subsets of the community gaming field.

Abstract: The present invention provides compositions and methods for inhibiting ACSS2 for modulating histone acetylation or for treating or preventing a neurological disease or disorder.

Abstract: A pluggable optical module configured to operate in a host device includes transmit optics; receive optics; an interface configured to connect to the host device, and communicatively coupled to the transmit optics and the receive optics; and circuitry communicatively coupled to the interface, wherein the circuitry is configured to, subsequent to insertion into the host device where the pluggable optical module initiates a boot process, provide an indication related to one or more of a status of the boot process and a time for the boot process to complete.

Abstract: Methods, devices and kits for sampling, releasing and stabilizing nucleic acid, including RNA and DNA, from virus, bacteria yeast and other cells is described. The released and stabilized nucleic acid may be analyzed and quantified without further sample preparation at the point of care or may be transported to a testing laboratory by shipment and analyzed directly. The nucleic acid, which can be RNA, remains safe and stable so that shipping by normal means including government postal service may be used. In addition, the RNA sample remains stable so that analysis can be performed immediately after receipt of sample or after storage for days, weeks or months. Storage may be at room or ambient temperature or cooler temperatures. The sampling apparatus used to acquire samples can interface with nucleic detection and measurement instrumentation including high throughput, parallel processing instruments.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to determine memory access integrity based on feedback from memory. An example apparatus includes an access reconstruction controller including an output, a first input configured to be coupled to memory, and a second input configured to be coupled to a memory signal generator; a comparator including a first input coupled to the output of the access reconstruction controller, a second input configured to be coupled to an arbiter, and an output configured to be coupled to the arbiter; and a data integrity monitor including an input coupled to the second input of the comparator and configured to be coupled to the arbiter and an output coupled to the output of the comparator and configured to be coupled to the arbiter.

Abstract: Provided are asynchronous data ingestion and enrichment systems and methods. The systems comprise a plurality of components (e.g., ingestion components, enrichment components, and/or publishing components). Instead of passing data from one component to another, the data is sent to a messaging queue that formats and hold the data until the subsequent component is ready to receive it. Additionally, each component comprises a central microservice and a plurality of instances, the central microservice configured to communicate with each instance of the plurality of instances.

Abstract: Disclosed herein are embodiments of a wound treatment apparatus with electronic components integrated within a wound dressing. In some embodiments, a wound dressing apparatus can comprise a wound contact layer, an absorbent layer over the wound contact layer, the absorbent layer comprising one or more apertures, a cover layer configured to cover and form a seal over the wound contact layer and the absorbent layer, and an electronics assembly comprising a negative pressure source. A portion of the cover layer overlying the one or more apertures in the absorbent layer can be configured to be compressed within the aperture in the absorbent layer when negative pressure is applied to the wound dressing apparatus. The compressed cover layer can indicate a level of negative pressure below the cover layer. In some embodiments, the wound dressing apparatus can comprise an indicator material layer and a cover layer configured to cover and form a seal over the wound contact layer and the indicator material layer.

Abstract: Disclosed is a method and system, in FIG. 1, for verifying authenticity of specific personal data responsive to a unique wallet address (70) on a public ledger (66) of an unregulated platform (60). The wallet contains one or more non-transferable NFTs each locked to the wallet and related to specific personal data. The non-transferable NFT was minted from a regulated platform (27) to which there is a record (76) in the public ledger. Supplying the unique address of the wallet to a service supplier affects a log-in of a client (18) to the service supplier (90), whereafter message interactions over a network (12) between the service supplier and the unregulated platform (60) permits searching for a relevant (72) non-transferable NFTs (74) stored in the wallet and related to the specific personal data. Return of any relevant non-transferable NFT related to the personal data thus verifies authenticity of the specific personal data by association with a regulated platform.

Abstract: A data file system includes one or more files about a patient wearing a wearable cardiac defibrillator (WCD) system that has been assigned to them. The one or more files contain at least one patient identifier of the patient, compliance data about a history of the patient's wearing the WCD system, and possibly other data. The data file system can be accessed through a communication network when the patient uses a communication device. When so accessed, some of the contents can be viewed on a screen of the device, for example in the form of a website.

Abstract: A system for providing a sustained, continuous pressure to a point on the body is provided. The system can include a stimulating projection in the form of a small molded piece that is secured to a point on a human body by an adhesive pad or tape. In another form the stimulating projection can include a clip on one side. The clip can be attached to a strap or garment worn on the body to keep the stimulating projection in place.

Abstract: An automatic cruise control system on a motorcycle capable of performing an overtake maneuver via a long button press. The automatic cruise control includes a radar, a button, and a motorcycle speed. The radar is configured to detect objects in front of the motorcycle and generate data regarding the detected object. The button is configured to generate a button signal. The radar is further configured to receive the motorcycle speed, sensor data, and a button signal, and to generate an acceleration signal based upon the sensor data, the button signal, and the motorcycle speed.