Abstract: A system for providing a sustained, continuous pressure to a point on the body is provided. The system can include a stimulating projection in the form of a small molded piece that is secured to a point on a human body by an adhesive pad or tape. In another form the stimulating projection can include a clip on one side. The clip can be attached to a strap or garment worn on the body to keep the stimulating projection in place.

Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: A method of manufacturing a pellicle for a lithographic apparatus, the method including locally heating the pellicle using radiative heating, and depositing coating material simultaneously on both sides of the pellicle, and pellicles manufactured according to this method. Also disclosed is the use of a multilayer graphene pellicle with a double-sided hexagonal boron nitride coating in a lithographic apparatus.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: W—X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of the AAV VP1 capsid protein is an AUG. Upstream of the VP1 open reading frame an alternative out of frame start codon is placed such that translation initiation of the VP1 protein is modified, i.e. reduced, to allow production of VP1:VP2:VP3 in a good stoichiometry resulting in AAV with high potency.

Abstract: A modular data center includes an outer wall having an opening formed therein. The opening is configured to enable a busway to pass through the outer wall. The modular data center further includes an electrical box configured to be coupled to the busway. The electrical box is positioned inboard with respect to the outer wall. The modular data center further includes a shroud configured to extend through the opening of the outer wall. The shroud includes a plurality of outer edges coupled to an outer surface of the outer wall. The modular data center further includes a cover, including a cover opening, configured to enable the busway to pass through the cover opening, and to at least partially seal the opening of the outer wall having the busway passing therethrough.

Abstract: A system for treating cardiac arrhythmias comprising a generator including: a sensing circuitry configured to evaluate one or more identified signals representative of electrical activity of the heart and detect an arrhythmia, a control circuitry that is configured to control delivery of a therapy in response to the detected arrhythmia, the therapy including a first stage of electrical pulses delivered via at least a first electrode, wherein the first set of electrical pulses is configured to destabilize and/or terminate a reentry associated with the arrhythmia, and a first lead coupled to the generator, wherein the first lead includes the first electrode. The therapy further includes a second stage of electrical pulses delivered via the first electrode and/or a second electrode, wherein the second stage of pulses is configured to terminate the reentry; and an inter-stage delay separating the first and second stages of electrical pulses.

Abstract: Described herein are systems and methods for assigning and managing RF communication links between ground-based stations and airborne assets. In one or more examples, a pilot or other user of the systems and methods described herein can generate and transmit a flight plan to a spectrum management system. Additionally, or alternatively, the pilot or use can also transmit additional information to the spectrum management system such as the type of aircraft/radio configuration that they will be using during a flight, and a request for a certain amount of data throughput that they want to have access to during the flight. In one or more examples, upon receiving the flight plan and/or information from the pilot, the spectrum management system can proceed to match the user's desired flight plan with one or more RF spectrum resources for the airborne radio of the pilot's UAV to use during their planned flight.

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

Abstract: A milling device for machining a slot into an inner surface of a casing for a gas turbine engine. The milling device includes a frame assembly including multiple structural guides configured to engage structural features on the inner surface of the casing to maintain an axial position of the milling device relative to a longitudinal axis of the casing. The milling device also includes a milling cutter coupled to the frame assembly. The milling device is configured to be displaced in a circumferential direction relative to the longitudinal axis to machine the slot, via the milling cutter, along the inner surface of the casing in the circumferential direction.

Abstract: An augmented reality (AR) node location and activation technique for use in an AR system in a process plant or other field environment quickly and easily detects an AR node in a real-world environment and is then able to activate an AR scene within the AR system, which improves the usability and user experience of the AR system. The AR node location and activation system generally enables users to connect to and view an AR scene within an AR system or platform even when the user is not directly at an existing AR node, when the user is experiencing poor lighting conditions in the real-world environment and in situations in which the user is unfamiliar with the AR nodes that are in the AR system database.

Abstract: Combination therapies are disclosed. The combination therapies can be used to treat or prevent cancerous conditions and/or disorders.

Abstract: A method may include obtaining a first sensor input signal and converting the first sensor input signal to a second sensor input signal having a common data format based on one or more data conversion rules. The method may include appending the second sensor input signal with a variable that describes information relating to the first sensor input signal. The method may include broadcasting the second sensor input signal in the common data format to one or more data storages and sending an instruction to actuate warehouse operations to one or more receiving systems based on the one or more data storages to which the second sensor input signal is broadcast. The method may include controlling one or more operations of a warehouse based on the instruction to actuate warehouse operations.

Abstract: An automatic cruise control system on a motorcycle capable of performing an overtake maneuver via a long button press. The automatic cruise control includes a radar, a button, and a motorcycle speed. The radar is configured to detect objects in front of the motorcycle and generate data regarding the detected object. The button is configured to generate a button signal. The radar is further configured to receive the motorcycle speed, sensor data, and a button signal, and to generate an acceleration signal based upon the sensor data, the button signal, and the motorcycle speed.

Abstract: Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Abstract: The present invention relates to a computer implemented system for animating a virtual object or digital entity. It has particular relevance to animation using biologically based models, or behavioural models particularly neurobehavioural models. There is provided a plurality of modules having a computational element and a graphical element. The modules are arranged in a required structure and have at least one variable and being associated with at least one connector. The connectors link variables between modules across the structure, and the modules together provide a neurobehavioural model. There is also provided a method of controlling a digital entity in response to an external stimulus.

Abstract: Systems and methods for incorporating social content items into a produced video are provided. The system presents a producer interface to a user that allows the user to query for social content items. The user may then select and arrange social content items in an on-air queue. In an on-air mode, the system generates a broadcast-ready on-air format of the social content items and provides a video stream including the broadcast-ready social content items in the on-air queue to a video production system. The broadcast-ready social content items are incorporated into a produced video by the video production system. The user may navigate through the social content items in the on-air queue while on camera as part of the produced video.

Abstract: A Wearable Cardiac Defibrillator (WCD) system is configured to be worn by a patient who carries a mobile communication device. The mobile communication device has a user interface that is configured to enable the patient to enter wireless inputs. The WCD system includes a communication module that is configured to establish a local comlink with the mobile communication device. The WCD system also includes a tethered action unit that has a user interface configured to enable the patient to enter action inputs. The WCD system can perform some of its functions in response to the action inputs or to the wireless inputs. Since the wireless inputs can be provided from the mobile communication device instead of the action unit, the patient is less likely to attract attention when entering them, and thus exhibit better compliance.

Abstract: A wearable cardiac defibrillator (“WCD”) system may include a support structure that a patient can wear, an energy storage module that can store an electrical charge, and a discharge circuit that can discharge the electrical charge through the patient so as to shock him or her, while the patient is wearing the support structure. Embodiments may actively take into account bystanders, both to protect them from an inadvertent shock, and also to enlist their help. In some embodiments, the WCD system includes a speaker system and a memory. Prompts have been saved in advance in the patient's own voice, and stored in the memory. In case of an emergency, the prompts may be played by the speaker system in the patient's own voice, and heard by a bystander.

Abstract: A data file system includes one or more files about a patient wearing a wearable cardiac defibrillator (WCD) system that has been assigned to them. The one or more files contain at least one patient identifier of the patient, compliance data about a history of the patient's wearing the WCD system, and possibly other data. The data file system can be accessed through a communication network when the patient uses a communication device. When so accessed, some of the contents can be viewed on a screen of the device, for example in the form of a website. In embodiments, the health care provider and friends and family can view such data and even enter inputs, which may create a situation that motivates the patient to comply better.