Abstract: Methods of producing multiple protein products from blood-based materials including alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins are described herein. The inventive methods include steps of: salt fractionation, chromatography, ultrafiltration, diafiltration, solvent-detergent treatment, and sterile filtration. Advantageously, the inventive methods are simple and produce alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins in high yields. The sequence of process steps can be selected to obtain multiple products from various in-process materials, such as supernatants, pastes, chromatography flow-though, and chromatography washes.

Abstract: A baby bouncer with assistance having a base, a seat to receive a baby, a joint connecting the seat with the base and configured to support the seat above the base, and an actuator connected between the base and the seat. The joint permits reciprocating motion of the seat relative to the base. The actuator can impart a driving force on the seat.

Abstract: In embodiments, a Wearable Cardiac Defibrillator (WCD) system is configured to be worn by an ambulatory patient. The WCD system includes a main user interface (UI) output device that can output an image, sound or vibration as a main message about a condition of the patient or the WCD system. The patient may further carry a peripheral device that can also output an image, sound or vibration as a peripheral message about the condition. The peripheral message may mirror the main message at least in part, amplify it, and so on. The availability of the peripheral message provides the patient with the opportunity to better perceive the main message, and the flexibility to receive and react to it discreetly, learn more about the condition, and so on.

Abstract: Described herein are compounds capable of modulating the level of activity of Serine/threonine protein kinase 3 (STK3) or serine/threonine protein kinase 4 (STK4), compositions, and methods of using these compounds and compositions.

Abstract: An automatic cruise control system on a motorcycle capable of performing an overtake maneuver via a long button press. The automatic cruise control includes a radar, a button, and a motorcycle speed. The radar is configured to detect objects in front of the motorcycle and generate data regarding the detected object. The button is configured to generate a button signal. The radar is further configured to receive the motorcycle speed, sensor data, and a button signal, and to generate an acceleration signal based upon the sensor data, the button signal, and the motorcycle speed.

Abstract: An agricultural autonomous vehicle is provided which is operable to traverse a field and perform one or more detection tasks.

Abstract: A telephone call processor for processing telephone calls comprising voice signals and data signals, the call processor comprising a first telephone interface and a second telephone interface, the call processor being operable in a first mode and in a second mode. In the first mode, the call processor is adapted to receive voice signals and data signals at the first telephone interface and to transmit voice signals and data signals via the second telephone interface. In the second mode, the call processor is adapted to receive voice signals and data signals at the first telephone interface, to block data signals from being transmitted via the second telephone interface and optionally to transmit voice signals via the second telephone interface.

Abstract: A thermal management device is provided. The thermal management device includes a first substrate, a second substrate, and a thermal spreader layer. The second substrate is arranged over the first substrate, and the thermal spreader layer is arranged between the first substrate and the second substrate. The thermal spreader layer includes a first thermally conductive piece having a first edge and a second thermally conductive piece having a first edge. The first edge of the first thermally conductive piece is disposed adjacent to the first edge of the second thermally conductive piece.

Abstract: An agricultural autonomous vehicle is provided which is operable to traverse a field and perform one or more detection tasks.

Abstract: An agricultural autonomous vehicle is provided which is operable to traverse a field and perform one or more detection tasks.

Abstract: Implementations of semiconductor packages may include: a digital signal processor having a first side and a second side and an image sensor array, having a first side and a second side. The first side of the image sensor array may be coupled to the second side of the digital signal processor through a plurality of hybrid bond interconnect (HBI) bond pads and an edge seal. One or more openings may extend from the second side of the image sensor array into the second side of the digital signal processor to an etch stop layer in the second side of the digital signal processor. The one or more openings may form a second edge seal between the plurality of HBI bond pads and the edge of the digital signal processor.

Abstract: Described herein are compounds which are inhibitors of oncogenic and wild-type SHP2 and methods of treatment using SHP2 inhibitors.

Abstract: Various analyte sensor systems for controlling activation of analyte sensor electronics circuitry are provided. Related methods for controlling analyte sensor electronics circuitry are also provided. Various analyte sensor systems for monitoring an analyte in a host are also provided. Various circuits for controlling activation of an analyte sensor system are also provided. Analyte sensor systems utilizing a state machine having a plurality of states for collecting a plurality of digital counts and waking a controller responsive to a wake up signal are also provided. Related methods for such analyte sensor systems are also provided. Systems for controlling activation of analyte sensor electronics circuitry utilizing a magnetic sensor are further provided. One or more display device configured to display one or more analyte concentration values are also provided.

Abstract: Various implementations include a switch assembly that includes a housing and at least two printed circuit boards (PCBs) that are disposed within the housing and are axially arranged relative to each other. One or more force sensors are disposed on one of the PCBs, and, in some implementations, the one or more force sensors receive force input received by a touch overlay plate. Signals from the force sensors are processed to determine a magnitude, acceleration, and/or location of the force input, and a haptic feedback response is received by the touch overlay plate. The haptic feedback response is based on the force magnitude, acceleration, and/or location of input, according to some implementations. Axially arranging the PCBs reduces the footprint of the switch assembly and allows for the inclusion of more electrical components in the switch assembly, according to some implementations.

Abstract: A supportive clothing article is provided for a wearable cardioverter defibrillator (WCDA belt includes a first end with a first portion of a fastener and a second end with a second portion of the fastener. The belt is structured to fasten around the torso of patient below the chest area of the patient. The belt includes a first conductive mesh portion adjacent the first end of the belt or the second end of the belt, two straps. A back portion extends from the belt at an intermediary position on the belt to each of the two straps. The back portion includes a conductive mesh, a first support receptacle attached to and extending from the belt and attachable to one of the two straps, and a second support receptacle attached to and extending from the belt and attachable to the other of the two straps.

Abstract: A locking cam for securing suspension components in a vehicle. The locking cam has at least one surface that is textured to create a surface for engagement against and with a frame member upon tightening of the suspension components. The textured surface can have ridges or projects for engagement with the frame member.

Abstract: Methods of producing multiple protein products from blood-based materials including alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins are described herein. The inventive methods include steps of: salt fractionation, chromatography, ultrafiltration, diafiltration, solvent-detergent treatment, and sterile filtration. Advantageously, the inventive methods are simple and produce alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins in high yields. The sequence of process steps can be selected to obtain multiple products from various in-process materials, such as supernatants, pastes, chromatography flow-though, and chromatography washes.

Abstract: A host device is configured to receive a pluggable optical module, and the host device includes circuitry configured to perform steps of, subsequent to insertion of the pluggable optical module into the host device and prior to the pluggable optical module being fully booted, wherein the pluggable optical module includes a plurality of registers, reading from or writing to one or more registers of the plurality of registers; and, responsive to the pluggable optical module being fully booted, operating the pluggable optical module including reading from or writing to any of the plurality of registers.

Abstract: Disclosed herein are embodiments of a wound treatment apparatus with electronic components integrated within a wound dressing. In some embodiments, a wound dressing apparatus can comprise a wound contact layer, an absorbent layer over the wound contact layer, the absorbent layer comprising one or more apertures, a cover layer configured to cover and form a seal over the wound contact layer and the absorbent layer, and an electronics assembly comprising a negative pressure source. A portion of the cover layer overlying the one or more apertures in the absorbent layer can be configured to be compressed within the aperture in the absorbent layer when negative pressure is applied to the wound dressing apparatus. The compressed cover layer can indicate a level of negative pressure below the cover layer. In some embodiments, the wound dressing apparatus can comprise an indicator material layer and a cover layer configured to cover and form a seal over the wound contact layer and the indicator material layer.

Abstract: There is provided a system operable to collect, from a customer, a response to a question relating to a transaction, the system comprising: a requesting device configured to send, to a questions server, data relating to the transaction and a request for a question; the questions server, comprising: a processor; one or more databases storing questions; and a rules engine, the questions server configured to: receive the data relating to the transaction and the request for a question from the requesting device; select a question from the stored questions based on the transaction data; and send the selected question to the requesting device; wherein the requesting device is further configured to: present the question to the customer or instruct a display device to present the question to a customer; wherein the system is further configured to: receive a response to the question; and send data related to the response to the questions server or a response database.