Patents by Inventor David Philpot
David Philpot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220241434Abstract: This invention relates to polynucleotides comprising UBE3A open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a UBE3A gene or aberrant activity of a UBE3A gene product in the subject, such as Angelman Syndrome.Type: ApplicationFiled: May 22, 2020Publication date: August 4, 2022Inventors: Benjamin David Philpot, Steven James Gray, Charles Shyng, Matthew Judson
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Patent number: 11001748Abstract: A method begins with the step of preparing a drag-reducing additive by mixing a dispersion polymer with a surfactant and a solvent. The method continues with the step of forming a drag-reducing composition by combining the drag-reducing additive with an aqueous treatment fluid. The method further involves the step of injecting the drag-reducing composition into a subterranean formation, a pipeline or a gathering line.Type: GrantFiled: November 30, 2018Date of Patent: May 11, 2021Assignee: Flotek Chemistry, LLCInventors: Andrei Zelenev, Lakia Champagne, David Philpot
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Patent number: 10696887Abstract: An oxidative breaker system for use in reducing the viscosity of a polysaccharide-based or derivatized polysaccharide-based suspension includes a silicone carrier fluid, an oxidizer, and a suspension aid. The suspension aid is preferably fumed silica. The oxidizer may be selected from the group consisting of alkali metal peroxide, transition metal peroxide, persulfate compound, bromide compound, and bromate compound. In highly preferred embodiments, the oxidizer is magnesium peroxide or calcium peroxide. Alternative carrier fluids and suspension agents are also included in the art. Also disclosed is a method for breaking a polysaccharide-based suspension with the inventive oxidative breaker system.Type: GrantFiled: May 15, 2017Date of Patent: June 30, 2020Assignee: Flotek Chemistry, LLCInventors: Keith Ingram Dismuke, David Philpot, Randal M. Hill, Rondell Pennypacker, Steven Hill, Thomas R. Sifferman
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Patent number: 10301630Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.Type: GrantFiled: June 22, 2017Date of Patent: May 28, 2019Assignee: The University of North Carolina at Chapel HillInventors: Benjamin David Philpot, Mark John Zylka, Bryan Leo Roth, John Arthur Allen, Hsien-Sung Huang
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Publication number: 20190093003Abstract: A method begins with the step of preparing a drag-reducing additive by mixing a dispersion polymer with a surfactant and a solvent. The method continues with the step of forming a drag-reducing composition by combining the drag-reducing additive with an aqueous treatment fluid. The method further involves the step of injecting the drag-reducing composition into a subterranean formation, a pipeline or a gathering line.Type: ApplicationFiled: November 30, 2018Publication date: March 28, 2019Applicant: Flotek Chemistry, LLCInventors: Andrei Zelenev, Lakia Champagne, David Philpot
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Patent number: 10144865Abstract: A method of preparing a drag-reducing composition that includes a dispersion polymer includes steps for preparing the dispersion polymer, steps for incorporating the dispersion polymer into a drag-reducing composition, and steps for using the drag-reducing composition. The step of preparing a dispersion polymer includes preparing an aqueous mixture by adding a water-soluble salt and at least one polymeric dispersant to water and polymerizing one or more water-soluble monomers in the aqueous mixture. Once the dispersion polymer has been combined with the drag-reducing additive, the combination is injected into a subterranean formation, a pipeline or a gathering line.Type: GrantFiled: February 27, 2018Date of Patent: December 4, 2018Assignee: Flotek Chemistry, LLCInventors: Andrei Zelenev, Lakia Champagne, David Philpot
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Publication number: 20180187068Abstract: A method of preparing a drag-reducing composition that includes a dispersion polymer includes steps for preparing the dispersion polymer, steps for incorporating the dispersion polymer into a drag-reducing composition, and steps for using the drag-reducing composition. The step of preparing a dispersion polymer includes preparing an aqueous mixture by adding a water-soluble salt and at least one polymeric dispersant to water and polymerizing one or more water-soluble monomers in the aqueous mixture. Once the dispersion polymer has been combined with the drag-reducing additive, the combination is injected into a subterranean formation, a pipeline or a gathering line.Type: ApplicationFiled: February 27, 2018Publication date: July 5, 2018Applicant: Flotek Chemistry, LLCInventors: Earl Parnell, Todd Sanner, Marlin Holtmyer, David Philpot, Andrei Zelenev, Gydeon Gilzow, Thomas Sifferman, Lakia Champagne
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Publication number: 20180016584Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.Type: ApplicationFiled: June 22, 2017Publication date: January 18, 2018Inventors: Benjamin David Philpot, Mark John Zylka, Bryan Lao Roth, John Arthur Allen, Hsien-Sung Huang
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Publication number: 20170313925Abstract: An oxidative breaker system for use in reducing the viscosity of a polysaccharide-based or derivatized polysaccharide-based suspension includes a silicone carrier fluid, an oxidizer, and a suspension aid. The suspension aid is preferably fumed silica. The oxidizer may be selected from the group consisting of alkali metal peroxide, transition metal peroxide, persulfate compound, bromide compound, and bromate compound. In highly preferred embodiments, the oxidizer is magnesium peroxide or calcium peroxide. Alternative carrier fluids and suspension agents are also included in the art. Also disclosed is a method for breaking a polysaccharide-based suspension with the inventive oxidative breaker system.Type: ApplicationFiled: May 15, 2017Publication date: November 2, 2017Applicant: Flotek Chemistry, LLCInventors: Keith Ingram Dismuke, David Philpot, Randal M. Hill, Rondell Pennypacker, Steven Hill, Thomas R. Sifferman
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Patent number: 9714427Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.Type: GrantFiled: November 9, 2011Date of Patent: July 25, 2017Assignee: The University of North Carolina at Chapel HillInventors: Benjamin David Philpot, Mark John Zylka, Bryan Leo Roth, John Arthur Allen, Hsien-Sung Huang
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Patent number: 8916508Abstract: A method of preparing and using a drag-reducing composition in a well treatment operation includes the step of preparing the drag-reducing composition by mixing a polymer emulsion that includes a first surfactant and a first solvent, with a second surfactant and a second solvent. The method continues with the step of combining the drag-reducing composition with an aqueous treatment fluid. The method further includes the step of injecting the drag-reducing composition and aqueous treatment fluid into a subterranean formation, a pipeline or a gathering line.Type: GrantFiled: October 14, 2011Date of Patent: December 23, 2014Assignee: CESI Chemical, Inc.Inventors: Earl Parnell, Todd Sanner, Marlin Holtmyer, David Philpot, Andrei Zelenev, Gydeon Gilzow, Lakia Champagne, Thomas Sifferman
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Publication number: 20140323366Abstract: A method of preparing and using a drag-reducing composition in a well treatment operation includes the step of preparing the drag-reducing composition by mixing a polymer emulsion that includes a first surfactant and a first solvent, with a second surfactant and a second solvent. The method continues with the step of combining the drag-reducing composition with an aqueous treatment fluid. The method further includes the step of injecting the drag-reducing composition and aqueous treatment fluid into a subterranean formation, a pipeline or a gathering line.Type: ApplicationFiled: July 3, 2014Publication date: October 30, 2014Inventors: Earl Parnell, Todd Sanner, Marlin Holtmyer, David Philpot, Andrei Zelenev, Gydeon Gilzow, Thomas Sifferman, Lakia Champagne
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Patent number: 8865632Abstract: A drag-reducing additive includes 40-85% by weight of a polymer emulsion that includes a polymer, a first surfactant, and a first solvent; 10-35% by weight of a second surfactant with an HLB greater than 8; and 5-30% by weight of a second solvent. In a preferred embodiment, the second solvent includes a terpene. In another preferred embodiment, the polymer is a copolymer that includes acrylamide and acrylic acid.Type: GrantFiled: November 10, 2008Date of Patent: October 21, 2014Assignee: CESI Chemical, Inc.Inventors: Earl Parnell, Todd Sanner, Marlin Holtmyer, David Philpot, Andrei Zelenev, Gydeon Gilzow, Lakia Champagne, Thomas Sifferman
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Publication number: 20140262274Abstract: An oxidative breaker system for use in reducing the viscosity of a guar-based suspension includes a silicone oil carrier fluid, an oxidizer and a suspension aid. The suspension aid is preferably fumed silica. The oxidizer may be selected from the group consisting of alkali metal peroxide, transition metal peroxide, persulfate, bromide and bromate. In highly preferred embodiments, the oxidizer is magnesium peroxide or calcium peroxide. Also disclosed is a method for breaking a guar-based suspension with the inventive oxidative breaker system.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Inventors: Keith Dismuke, David Philpot, Randal Hill, Rondell Pennypacker, Steven Hill
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Publication number: 20140274822Abstract: An oxidative breaker system for use in reducing the viscosity of a polysaccharide-based or derivatized polysaccharide-based suspension includes a silicone carrier fluid, an oxidizer, and a suspension aid. The suspension aid is preferably fumed silica. The oxidizer may be selected from the group consisting of alkali metal peroxide, transition metal peroxide, persulfate compound, bromide compound, and bromate compound. In highly preferred embodiments, the oxidizer is magnesium peroxide or calcium peroxide. Alternative carrier fluids and suspension agents are also included in the art. Also disclosed is a method for breaking a polysaccharide-based suspension with the inventive oxidative breaker system.Type: ApplicationFiled: October 16, 2013Publication date: September 18, 2014Applicant: CESI Chemical, Inc.Inventors: Keith Dismuke, David Philpot, Randal Hill, Rondell Pennypacker, Steven Hill, Thomas R. Sifferman
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Publication number: 20130317018Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.Type: ApplicationFiled: November 9, 2011Publication date: November 28, 2013Inventors: Benjamin David Philpot, Mark John Zylka, Bryan Leo Roth, John Arthur Allen, Hsien-Sung Huang
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Publication number: 20120035085Abstract: A method of preparing and using a drag-reducing composition in a well treatment operation includes the step of preparing the drag-reducing composition by mixing a polymer emulsion that includes a first surfactant and a first solvent, with a second surfactant and a second solvent. The method continues with the step of combining the drag-reducing composition with an aqueous treatment fluid. The method further includes the step of injecting the drag-reducing composition and aqueous treatment fluid into a subterranean formation, a pipeline or a gathering line.Type: ApplicationFiled: October 14, 2011Publication date: February 9, 2012Applicant: CESI CHEMICAL, INC.Inventors: Earl Parnell, Todd Sanner, Marlin Holtmyer, David Philpot, Andrei Zelenev, Gydeon Gilzow, Lakia Champagne, Thomas Sifferman