Patents by Inventor David Pioli

David Pioli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides and polypeptide analogues
    Publication number: 20060068480
    Abstract: Polypeptides, in particular the polypeptide of formula I: Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys-Pro-Gly-Ser-Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala-Met-Leu-Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys- Asp-Thr-Asp-Cys-Pro-Gly-Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-Cys-Gly-Met-Ala-Cys-Phe-Val-Pro-Gln and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.
    Type: Application
    Filed: March 21, 2005
    Publication date: March 30, 2006
    Applicant: Oliver Wiedow
    Inventors: Enno Christophers, Oliver Wiedow, Jens-Michael Schroder, Michael Edge, David Pioli
  • Nucleic acids
    Patent number: 6893843
    Abstract: Polypeptides, in particular the polypeptide of formula I: Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys- Pro-Gly-Ser-Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala- Met-Leu-Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys-Asp-Thr- Asp-Cys-Pro-Gly-Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser- Cys-Gly-Met-Ala-Cys-Phe-Val-Pro-Gln and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: May 17, 2005
    Inventors: Enno Christophers, Oliver Wiedow, Jens-Michael Schroder, Michael Derek Edge, David Pioli
  • T7 promoter-based expression system
    Patent number: 6537779
    Abstract: An improved T7 based promoter-driven protein expression system comprising an operator sequence downstream of the T7 promoter sequence, and having a further operator sequence upstream of the T7 promoter sequence.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: March 25, 2003
    Assignee: Zeneca Limited
    Inventors: Bhupendra Vallabh Kara, David Pioli, Kenneth Robert Bundell, Robert Craig Hockney
  • Polypeptides and polypeptide analogues
    Publication number: 20020187535
    Abstract: Polypeptides, in particular the polypeptide of formula I: 1 Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys- Pro-Gly-Ser-Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala-Met-Leu- Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys-Asp-Thr-Asp-Cys-Pro-Gly- Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-Cys-Gly-Met-Ala-Cys- Phe-Val-Pro-Gln
    Type: Application
    Filed: April 13, 2001
    Publication date: December 12, 2002
    Inventors: Enno Christophers, Oliver Wiedow, Jens-Michael Schroder, Michael Derek Edge, David Pioli
  • Regulation of gene expression
    Patent number: 6010887
    Abstract: Pseudo-operator sequences may be located in (or inserted into) plant genomes and utilized to drive expression of foreign genes. These pseudo-operator sequences are nucleotide sequences which are present at a suitable location in a gene at which repressor binding will lead to inhibitation or enhancement of gene expression. The disclosed technique permits the design of altered specificity repressors, which bind the pseudo-operators.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: January 4, 2000
    Assignees: Imperial Chemical Industries PLC, University of Leicester
    Inventors: Ian George Bridges, Simon William Jonathan Bright, Andrew James Greenland, Wolfgang Walter Schuch, Andrew Merryweather, David Pioli
  • Regulation of gene expression
    Patent number: 5554510
    Abstract: The present invention relates to the regulation of gene expression which entails providing a pair of unlike proteins, with unlike DNA binding domains, which will associate to form a heterodimer and bind to appropriate asymmetric DNA binding sites and hence depress or increase expression of adjacent genes.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: September 10, 1996
    Assignees: Imperial Chemical Industries, PLC, President and Fellows of Harvard College
    Inventors: Melvyn Hollis, David Pioli, Dario Valenzuela