Abstract: A packaged intermittent urinary catheter comprising a single use catheter, a packaging surrounding the catheter, and a fluid reservoir holding a lubricant which, upon rupturing the fluid reservoir, is transferred into the packaging to immerse at least a portion of the catheter in the lubricant to prepare the catheter for use, wherein the lubricant comprises an antimicrobial medium. The invention further provides a method of using a packaged intermittent urinary catheter, and the use of a medium comprising at least one species independently chosen from: hypochlorous acid, at least one hypochlorite salt, chlorine dioxide, at least one chlorhexidine salt, and combinations thereof, as an antimicrobial medium for a single use intermittent urinary catheter.

Abstract: Methods for forming arrays of droplets, and associated arrays of droplets, are generally provided.

Abstract: The present invention relates to isolated nucleic acid molecules, comprising a functional mammalian EGR-1 (early growth response protein 1) promoter region that is operatively linked to a gene encoding a fluorescent protein and controls expression of said gene. The present invention further relates to nucleic acid vectors, comprising said nucleic, cells comprising said nucleic acids or vectors, being capable of sensing and indicating fluid shear stress acting on themselves, and methods of generating the same. Furthermore, the present invention relates to methods of evaluating fluid shear stress acting on cells in real-time during the operation of a biotechnological device or system, methods of evaluating a biotechnological device or system with respect to fluid shear stress acting on cells caused by operation of said device or system, and methods of designing a biotechnological device or system, said methods using said cells.

Abstract: The present disclosure is a urinary catheter that has a hollow polymeric tubular body that has a base polymer and an amphiphilic additive. In one aspect of the disclosure, at least a part of the body is coated with an aqueous gel, wherein the gel comprises water in a total amount of between 5-99 wt. %.

Abstract: A method of measuring a radiation dosage during irradiation includes disposing a first sensor in a first package with a first biocontainer and disposing a second sensor in a second package with a second biocontainer. The method further includes placing the first package and the second package in a container and irradiation the container including the first package and the second package. During or after irradiation, a first radiation dosage associated with the first biocontainer is measured with the first sensor and a second radiation dosage associated with the second biocontainer is measured with the second sensor.

Abstract: A reusable urinary catheter kit that has a container that has a urinary catheter and a medium. The reusable urinary catheter kit also has at least one chlorine-containing species. The container of the reusable urinary catheter kit is resealable. Further, the catheter in the reusable urinary catheter kit is an intermittent urinary catheter.

Abstract: The invention provides a reusable urinary catheter kit comprising a container comprising: a urinary catheter; and a medium comprising at least one species independently chosen from: hypochlorous acid, at least one hypochlorite salt, chlorine dioxide, and combinations thereof. The invention further provides a method of sterilising and/or lubricating a reusable urinary catheter using at least one species independently chosen from: hypochlorous acid, at least one hypochlorite salt, chlorine dioxide, and combinations thereof.

Abstract: A radiation dose sensor that measures a radiation dose of a biocontainer formed for a first material includes a first electrode, a second electrode, and a film. The first electrode has a plurality of first fingers. And the second electrode has a plurality of second fingers. The fingers of the first electrode extend towards and are interdigitated with the fingers of the second electrode that extend towards the first electrode with gaps formed between the first and second fingers. The film coats the interdigitated fingers and is disposed within the gaps. The film is formed of a second material that is similar to the first material that forms the biocontainer.

Abstract: A catheter storage and sterilisation device that has a housing and a removeable cartridge, the cartridge including a catheter-receiving chamber for receiving a catheter. The cartridge being removably attachable to the housing and having an opening in fluid communication with the housing. The housing has a chamber for receiving a sterilisation fluid and a mechanism for supplying a sterilisation fluid to the cartridge via the opening.

Abstract: A catheter storage and sterilisation device (99); the device comprising a catheter-receiving chamber (10) for receiving a catheter (1); a sterilisation fluid storage means (70) for storing a sterilisation fluid and an atomiser (53) or vaporiser configured to atomise or vaporise the sterilisation fluid to form an atomised or vaporised sterilisation fluid and to supply the atomised or vaporised sterilisation fluid to the catheter-receiving chamber (10).

Abstract: A radiation dose sensor that measures a radiation dose of a biocontainer formed for a first material includes a first electrode, a second electrode, and a film. The first electrode has a plurality of first fingers. And the second electrode has a plurality of second fingers. The fingers of the first electrode extend towards and are interdigitated with the fingers of the second electrode that extend towards the first electrode with gaps formed between the first and second fingers. The film coats the interdigitated fingers and is disposed within the gaps. The film is formed of a second material that is similar to the first material that forms the biocontainer.

Abstract: A method of sterilizing biocontainers including irradiating a biocontainer and measuring a radiation dose received by the biocontainer. The method also includes determining an ageing time of the biocontainer after irradiation based on the radiation dose received by the biocontainer and preventing use of the biocontainer before the ageing time has elapsed.

Abstract: A method of measuring a radiation dosage during irradiation includes disposing a first sensor in a first package with a first biocontainer and disposing a second sensor in a second package with a second biocontainer. The method further includes placing the first package and the second package in a container and irradiation the container including the first package and the second package. During or after irradiation, a first radiation dosage associated with the first biocontainer is measured with the first sensor and a second radiation dosage associated with the second biocontainer is measured with the second sensor.

Abstract: The present invention relates to isolated nucleic acid molecules, comprising a functional mammalian EGR-1 (early growth response protein 1) promoter region that is operatively linked to a gene encoding a fluorescent protein and controls expression of said gene. The present invention further relates to nucleic acid vectors, comprising said nucleic, cells comprising said nucleic acids or vectors, being capable of sensing and indicating fluid shear stress acting on themselves, and methods of generating the same. Furthermore, the present invention relates to methods of evaluating fluid shear stress acting on cells in real-time during the operation of a biotechnological device or system, methods of evaluating a biotechnological device or system with respect to fluid shear stress acting on cells caused by operation of said device or system, and methods of designing a biotechnological device or system, said methods using said cells.

Abstract: Fluidic modules configured for flowing fluid through membranes and associated methods are generally provided. In some embodiments, a fluidic module comprises two channels between which a membrane is positioned. The two channels may have geometries such that the pressure drop experienced by a fluid flowing from the first channel, through the membrane, and into the second channel is substantially independent of the location along the channel at which it flows through the membrane. In other words, the pressure drop may be substantially constant over the membrane area.

Abstract: Methods for forming arrays of droplets, and associated arrays of droplets, are generally provided.

Abstract: The invention provides an intermittent catheter comprising a hollow polymeric tubular body comprising a base polymer and a layer comprising a lubricious additive on or comprising a surface of the body, wherein the lubricious additive comprises an amphiphilic molecule.

Abstract: The invention provides a packaged intermittent catheter, the intermittent catheter comprising a hollow polymeric tubular body comprising a base polymer and an amphiphilic lubricious additive, housed in a packaging container; and further comprising an aqueous solution in the packaging container; wherein the aqueous solution comprises at least one compound selected from the group comprising: a surfactant and/or poly (alkylene oxide) compound with a total concentration of at least 0.005 mmol/L; and a salt in a concentration of at least 5% w/v.

Abstract: The invention relates to intermittent catheters comprising a calixarene bonded to a surface thereof, in particular to provide a bacteria-repellent and/or lubricous coating on the outer surface of an intermittent catheter. The calixarene moiety may comprises hydrophilic surface groups to provide lubricity, whilst also providing a bacteria-repellent effect, especially useful preventing discomfort and/or infection for a user inserting multiple catheters per day.

Abstract: The present invention is concerned with novel processes for the preparation of (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol (CAS # 30071-93-3). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.