Abstract: The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects. As a non-limiting example, the disclosed embodiments can be used to increase the production of certain proteins (e.g., hyaluronan synthase 3 (HAS3); fibronectin; tropoelastin; procoll1; integrin, etc.) in the skin, which results in anti-aging effects by increasing epidermal cohesion.

Abstract: Software downloads to Internet of things (IoT) devices are facilitated over a constrained network. In one embodiment a method comprises monitoring, by a network device comprising a processor, data determined to have been sent to a device for transmission to the device via a radio access network device of a wireless communication network, and determining, by the network device, a type of traffic associated with the data. The method further includes based on a determination that the data comprises firmware and that the type of traffic is of a traffic priority that is lower than a defined traffic priority, applying, by the network device, a low priority transport protocol to the data, wherein the applying comprises associating protocol information with the data representative of the low priority transport protocol.

Abstract: A brush comprises a plurality of filaments having a crimp structure and a J structure to provide a full distribution of filaments at an end surface of the brush, wherein the crimp structure of a majority of the filaments is configured with a period length of 2 mm to 5 mm and a peak to peak length of not greater than 0.8 mm, and the J structure is configured with a long length about 0.02 inches to about 1.2 inches, and a difference between the long length and a short length is about 0.2 inches to about 0.5 inches.

Abstract: Methods and systems for achieving higher efficiencies and capacities in sorting feed material are described herein, such as for separating desirable “good” rock or ore from undesirable “bad” rock or ore in an unsegregated, unseparated stream of feed material. In the disclosure, higher efficiencies are achieved with combinations of multiple sensor/diverter cells in stages in a cascade arrangement. The number and combination of cells in the cascade may be determined through a priori characterization of probabilities involved in sensor/rock and rock/diverter interactions, and mathematical determinations of the optimal number and combination of stages based on this probability. Further, as disclosed herein, desired sorting capacities are achieved through addition of multiple cascades in parallel until the desired sorting capacity is reached.

Abstract: A keratinous treatment kit is configured to apply a semi-solid or solid, non-Newtonian cosmetic composition onto a surface of keratinous tissue, wherein the cosmetic kit is packaged in a unitary package. The keratinous treatment kit includes a hybrid applicator, a hand piece, and a semi-solid or solid non-Newtonian cosmetic composition. The hybrid applicator includes a base and cleaning elements, the cleaning elements including a bristled brush and a elastomer contact surface. The handpiece includes a body and a motor, the body configured to receive the hybrid applicator, and the motor arranged and disposed to provide oscillating motion to the hybrid applicator, when attached, relative to the body. The semi-solid or solid, non-Newtonian cosmetic composition is transformable to a spreadable consistency when subjected to oscillating contact with the hybrid applicator. Also provided is a cosmetic application method of utilizing the cosmetic kit.

Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

Abstract: The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects. As a non-limiting example, the disclosed embodiments can be used to increase the production of certain proteins (e.g., hyaluronan synthase 3 (HAS3); fibronectin; tropoelastin; procoll1; integrin, etc.) in the skin, which results in anti-aging effects by increasing epidermal cohesion.

Abstract: The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects. As a non-limiting example, the disclosed embodiments can be used to increase the production of certain proteins (e.g., hyaluronan synthase 3 (HAS3); fibronectin; tropoelastin; procoll1; integrin, etc.) in the skin, which results in anti-aging effects by increasing epidermal cohesion.

Abstract: The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects. As a non-limiting example, the disclosed embodiments can be used to increase the production of certain proteins (e.g., hyaluronan synthase 3 (HAS3); fibronectin; tropoelastin; procoll1; integrin, etc.) in the skin, which results in anti-aging effects by increasing epidermal cohesion.

Abstract: The disclosed aspects and embodiments provide compositions, systems, and methods for applying a warming cosmetic composition in a manner that provides unexpected levels of temperature increase (on a per mass basis) and prevents aggregation of inorganic components of the composition. In one aspect, a composition is provided that includes an anhydrous medium and at least one exothermic heating agent, wherein the composition is configured to provide increased temperature when exposed to water sufficient to initiate an exothermic reaction and mixing energy, as compared to the composition when exposed to water in the absence of mixing energy.

Abstract: A device for stimulating saliva production in a subject includes a source of vibratory motion and a saliva stimulation assembly configured to elicit a salivary response by delivery of a vibratory stimulus. The saliva stimulation assembly includes one or more contact points coupled to the source of vibratory motion and configured to be placed against one or more stimulation sites on one or more portions of skin of the subject. The source of vibratory motion is configured such that, when the source of vibratory motion is operating and the one or more contact points are placed against the stimulation site, the one or more contact points vibrate at a stimulation frequency that produces a stimulus transmitted via the at least one portion of skin to the one or more salivary glands to stimulate saliva production by the one or more salivary glands.

Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

Abstract: A linear actuator includes an oscillating component that includes a threaded element, a traveler located inside the oscillating component that includes a mating threaded element, and a directional clutch located between the oscillating component and the traveler. The oscillating component is configured to be coupled to a source of oscillating motion and to be driven by the source of oscillating motion to cause oscillatory movements of the oscillating component. The directional clutch is configured to cause the oscillating component to drive the traveler in the first rotational direction when the oscillating component is rotated in the first rotational direction and to allow the oscillating component to slip by the traveler when the oscillating component is rotated in the second rotational direction. The threaded element and the mating threaded element are engaged such that rotational movement of the traveler in the first rotational direction causes linear movement of the traveler.

Abstract: Methods and systems for achieving higher efficiencies and capacities in sorting feed material are described herein, such as for separating desirable “good” rock or ore from undesirable “bad” rock or ore in an unsegregated, unseparated stream of feed material. In the disclosure, higher efficiencies are achieved with combinations of multiple sensor/diverter cells in stages in a cascade arrangement. The number and combination of cells in the cascade may be determined through a priori characterization of probabilities involved in sensor/rock and rock/diverter interactions, and mathematical determinations of the optimal number and combination of stages based on this probability. Further, as disclosed herein, desired sorting capacities are achieved through addition of multiple cascades in parallel until the desired sorting capacity is reached.

Abstract: An end effector is capable of being used to stimulate a portion of skin at a stimulation frequency. The end effector includes a base portion that is couplable to a motor and an end portion having a plurality of contact points at which the end effector is configured to contact the portion of skin. The plurality of contact points are located at a target distance from each other that is based on an inverse of the stimulation frequency. The end effector is configured such that, when the base portion is coupled to the motor and the motor is operating, the end effector has a resonant frequency based on the stimulation frequency. When the motor is operating and a force is applied to bias the end effector toward the portion of skin, a cyclical stimulus is produced within the portion of skin at about the stimulation frequency.

Abstract: Methods and systems for achieving higher efficiencies and capacities in sorting feed material are described, such as for separating desirable “good” rock or ore from undesirable “bad” rock or ore in an unsegregated, unseparated stream of feed material. Higher efficiencies are achieved with combinations of multiple sensor/diverter cells in stages in a cascade arrangement. The number and combination of cells in the cascade may be determined through a priori characterization of probabilities involved in sensor/rock and rock/diverter interactions, and mathematical determinations of the optimal number and combination of stages based on this probability. Further, desired sorting capacities are achieved through addition of multiple cascades in parallel until the desired sorting capacity is reached.

Abstract: A linear actuator includes an oscillating component that includes a threaded element, a traveler located inside the oscillating component that includes a mating threaded element, and a directional clutch located between the oscillating component and the traveler. The oscillating component is configured to be coupled to a source of oscillating motion and to be driven by the source of oscillating motion to cause oscillatory movements of the oscillating component. The directional clutch is configured to cause the oscillating component to drive the traveler in the first rotational direction when the oscillating component is rotated in the first rotational direction and to allow the oscillating component to slip by the traveler when the oscillating component is rotated in the second rotational direction. The threaded element and the mating threaded element are engaged such that rotational movement of the traveler in the first rotational direction causes linear movement of the traveler.

Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.