Patents by Inventor David Pruess

David Pruess has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-(3-Alanyl)clavam antibiotic
    Patent number: 4202819
    Abstract: A novel bioactive substance of the formula ##STR1## is produced in the fermentation of Streptomyces clavuligerus. Also disclosed is a fermentation method of making the substance. The substance exhibits in vitro antimicrobial activity in defined minimal medium and antifungal activity in natural medium.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: May 13, 1980
    Assignee: Hoffman-La Roche Inc.
    Inventors: Martha Kellett, David Pruess, James P. Scannell
  • Antibiotic 1745A/X and methods for the production thereof
    Patent number: 4152424
    Abstract: A new antibiotic, designated as antibiotic 1745A/X, is produced by the fermentation of the known microorganism Streptomyces antibioticus, ATCC 11891, using the novel compound erythronolide A oxime as the substrate. This new antibiotic is useful an an antibacterial agent.
    Type: Grant
    Filed: March 16, 1978
    Date of Patent: May 1, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard W. Kierstead, Ronald A. LeMahieu, David Pruess
  • Antibiotic X-1092
    Patent number: 3993545
    Abstract: The invention relates to a new and useful antibacterial substance which is of the formula ##EQU1## and to processes for its production and recovery. The invention embraces this antibacterial agent and its salts as crude concentrates, as purified solids and in pure crystalline forms. This antibiotic of the Formula I is effective in inhibiting the growth of gram positive bacteria. The compound of the Formula I is prepared by cultivating a strain of Streptomyces sp. X-1092 in an aqueous carbohydrate solution containing a nitrogenous nutrient under submerged aerobic conditions until substantial activity versus Gram-positive bacteria is imparted to said solution and then recovering said compound of the Formula I from said solution.
    Type: Grant
    Filed: November 10, 1975
    Date of Patent: November 23, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Pruess, James Parnell Scannell
  • Antibiotic 1745A/X and methods for the production thereof
    Patent number: 3992264
    Abstract: A new antibiotic, designated as antibiotic 1745A/X, is produced by the fermentation of the known microorganism Streptomyces antibioticus, ATCC 11891, using the novel compound erythronolide A oxime as the substrate. This new antibiotic is useful as an antibacterial agent.
    Type: Grant
    Filed: July 23, 1975
    Date of Patent: November 16, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Wightman Kierstead, Ronald Andrew Le Mahieu, David Pruess
  • New antibiotic X-1092
    Patent number: 3939139
    Abstract: The invention relates to a new and useful antibacterial substance which is of the formula ##EQU1## and to processes for its production and recovery. The invention embraces this antibacterial agent and its salts as crude concentrates, as purifed solids and in pure crystaline forms. This antibiotic of the Formula I is effective in inhibiting the growth of gram positive bacteria. The compound of the Formula I is prepared by cultivating a strain of Streptomyces sp. X-1092 in an aqueous carbohydrate solution containing a nitrogenous nutrient under submerged aerobic conditions until substantial activity versus Gram-positive bacteria is imparted to said solution and then recovering said compound of the Formula I from said solution.
    Type: Grant
    Filed: September 9, 1974
    Date of Patent: February 17, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Pruess, James Parnell Scannell