Patents by Inventor David Puleo

David Puleo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule drug release from in situ forming degradable scaffolds incorporating hydrogels and bioceramic microparticles
    Patent number: 10682442
    Abstract: The present invention relates to an injectable system combining a hydrogel, a bioceramic and a degradable matrix that provides for sustained drug delivery and structural support to recovering tissue, such as bone and the periodontium.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: June 16, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: David Puleo, Todd Milbrandt, James Zach Hilt, Paul Fisher, Vishwas Talwalkar
  • Bilayered calcium sulfate/calcium phosphate space-making composites with multiple drug delivery capabilities
    Patent number: 9895354
    Abstract: The present invention provides for bilayered composites that provide for sustained drug delivery and support to recovering tissue(s) and areas surrounding, such as with bone tissue. The two layers degrade at separate rates, thereby providing sustained mechanical support and tailored drug delivery.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: February 20, 2018
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: David Puleo, Bryan Orellana, Mike McQuinn
  • Polymeric prodrug
    Patent number: 9433638
    Abstract: The presently-disclosed subject matter includes compounds that comprise an initiator and an active agent that is covalently bonded to the initiator through a ring-opening polymerization process, an atom-transfer radical polymerization process, a Michael addition reaction, or a ring-opening metathesis polymerization process. In some embodiments the active agent includes simvastatin. The presently-disclosed subject matter also includes methods for making the compositions and methods for using the compositions to treat tissue wounds.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: September 6, 2016
    Assignee: University of Kentucky Research Foundation
    Inventors: David Puleo, Thomas Dziubla, Theodora Asafo-Adjei
  • Small molecule drug release from in situ forming degradable scaffolds incorporating hydrogels and bioceramic microparticles
    Publication number: 20150290361
    Abstract: The present invention relates to an injectable system combining a hydrogel, a bioceramic and a degradable matrix that provides for sustained drug delivery and structural support to recovering tissue, such as bone and the periodontium.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 15, 2015
    Inventors: David Puleo, Todd Milbrandt, James Zach Hilt, Paul Fischer, Vishwas Talwalkar
  • Bilayered Calcium Sulfate/Calcium Phosphate Space-Making Composites with Multiple Drug Delivery Capabilities
    Publication number: 20150283089
    Abstract: The present invention provides for bilayered composites that provide for sustained drug delivery and support to recovering tissue(s) and areas surrounding, such as with bone tissue. The two layers degrade at separate rates, thereby providing sustained mechanical support and tailored drug delivery.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 8, 2015
    Inventors: David Puleo, Bryan Orellana, Mike McQuinn
  • Footholds for fall protection devices
    Publication number: 20050194211
    Abstract: A foothold system for attachment to a fall protection device includes at least one foot upon which a user can rest a foot and an attachment member in operative connection with the foot seating. The attachment member is adapted to attach to the fall protection device (for example, a safety harness, a safety belt or a lanyard).
    Type: Application
    Filed: March 4, 2005
    Publication date: September 8, 2005
    Inventors: James O'Shall, Jeffrey LeMier, John Frey, David Puleo, David Hoffman, Philip Cozad, Charles Ziegler