Patents by Inventor David R. Bolin

David R. Bolin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic vasoactive intestinal peptide analogs
    Patent number: 5234907
    Abstract: Vasoactive intestinal compound analogs containing substitutions of appropriately selected amino acids at specific positions of the VIP molecule.
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: August 10, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventor: David R. Bolin
  • Synthetic vasoactive intestinal peptide analogs
    Patent number: 5141924
    Abstract: Vasoactive intestinal peptide analogs containing substitutions of appropriately selected amino acids at specific positions of the VIP molecule.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: August 25, 1992
    Assignee: Hoffmann-La Roche, Inc.
    Inventor: David R. Bolin
  • Method for the production of amino terminus protected naturally occurring amino acids
    Patent number: 4822890
    Abstract: A method for the production of substantially 100% pure N.alpha.-urethane protected amino acids is disclosed. This method eliminates the formation of di-peptide and tri-peptide contaminants. Reaction of blocking reagents at the carboxylate site on a protected peptide is prevented by the application of labile amino acid esters. Subsequent removal of the ester yields, in ultra-high purity, the N.alpha.-protected amino acid. The substantially 100% pure N.alpha.-urethane protected amino acid are also disclosed.
    Type: Grant
    Filed: June 24, 1986
    Date of Patent: April 18, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventor: David R. Bolin
  • Synthetic vasoactive intestinal peptide analogs
    Patent number: 4734400
    Abstract: Novel vasoactive intestinal peptide analogs containing substitutions of appropriately selected amino acids at specific positions of the VIP molecule, with potent sustained bronchodilatory activity without cardiovascular side effects.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: March 29, 1988
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David R. Bolin, Johannes A. Meienhofer, Iou-Iou Sytwu
  • Synthetic vasoactive intestinal peptide analogs
    Patent number: 4605641
    Abstract: Novel vasoactive intestinal peptide analogs containing substitutions of appropriately selected amino acids at specific positions of the VIP molecule, with potent sustained bronchodilatory activity without cardiovascular side effects.
    Type: Grant
    Filed: October 9, 1984
    Date of Patent: August 12, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David R. Bolin, Johannes A. Meienhofer, Iou-Iou Sytwu