Patents by Inventor David R. Borcherding

David R. Borcherding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-substituted adenosines with A-2 receptor affinity
    Patent number: 5426101
    Abstract: The compound (R)-2-[(phenylisopropyl)amino]adenosine whose structure is given below: ##STR1## (R)-2-[(phenylisopropyl)amino]adenosine is about two orders of magnitude greater in its selectivity between the A-1 and A-2 adenosine receptors than its diastereoisomer. This compound is useful for lowering blood pressure.
    Type: Grant
    Filed: September 15, 1994
    Date of Patent: June 20, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Norton P. Peet, David R. Borcherding, Nelsen L. Lentz, Philip M. Weintraub, Philip R. Kastner
  • Carbocyclic adenosine analogs useful as immunosuppressants
    Patent number: 5244896
    Abstract: This invention relates to novel carbocyclic adenosine compounds of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent,Y.sub.3, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group,Q is NH.sub.2, halogen or hydrogen, andZ is hydrogen, halogen, or NH.sub.2 ;or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: September 14, 1993
    Assignee: Marion Merrell Dow Inc.
    Inventors: David R. Borcherding, Carl K. Edwards, III, Ronald E. Esser, Douglas L. Cole
  • Benzothiazepines
    Patent number: 5001236
    Abstract: Certain 1,5-benzothiazepines are useful intermediates or pharamceuticals.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: March 19, 1991
    Assignee: Marion Laboratories, Inc.
    Inventors: David R. Borcherding, Daniel E. Martin
  • Process for preparing 2-aromatic-3-halobenzothiazepines
    Patent number: 4983733
    Abstract: 2-Aromatic-3-HALobenzothizepines are prepared by reaction of a 2,3-dihydro-2-aromatic-3-hydroxybenzothiazepine with a thionyl HALide. For example, dl-cis-2-(4-methoxyphenyl)-2,3-dihydro-3-hydroxy-1, 5-benzothiazzepin-4(5H)-one relfuxed with thionyl chloride can prepare E-2-(4-methoxyphenyl)-3-chloro-1,5-benzothiazepin-4(5H)-one in 66 percent yield.
    Type: Grant
    Filed: November 20, 1989
    Date of Patent: January 8, 1991
    Assignee: Marion Laboratories, Inc.
    Inventor: David R. Borcherding
  • Hydroxylated ene ketones, acetylenic grignards and hydroxylated yne ketones therefrom
    Patent number: 4973756
    Abstract: An alpha-hydroxyl-alpha,alpha-di(inert-substituted)-gamma',delta'-yne ketone can be prepared by a procedure comprising contacting an acetylenic Grignard reagent with an alpha-hydroxyl-alpha,alpha-di(inert substituted)-alpha',beta'-ene ketone, and the alpha-hydroxyl-alpha,alpha-di(inert-substituted)-alpha',beta'-ene ketone can be prepared by a procedure comprising steps of contacting, first, an alkoxy allene with a lithium donating organic agent, second, product of the first step with a di(inert-substituted)ketone, and third, product of the second step with an acidic substance.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: November 27, 1990
    Assignee: Marion Laboratories, Inc.
    Inventors: Hans Wynberg, Wolter T. Hoeve, Gerrit A. Barf, Johannes N. Koek, David R. Borcherding
  • Nucleoside analogues having antiviral activity
    Patent number: 4859677
    Abstract: Compounds of the formula (I) ##STR1## wherein X is .dbd.N-- or .dbd.CH-- and physiologically acceptable salts and solvents thereof which have antiviral activity, a process for the preparation of the compounds and intermediates thereof, pharmaceutical compositions containing the compounds and a method for inhibiting the propagation of virus using the compounds.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: August 22, 1989
    Assignee: University of Kansas
    Inventors: Ronald T. Borchardt, David R. Borcherding