Patents by Inventor David R. Brigstock

David R. Brigstock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heparin-Binding Growth Factor (HBGF) Polypeptides
    Publication number: 20110160445
    Abstract: Substantially pure heparin-binding growth factor polypeptides (HBGFs), nucleic acids encoding the HBGFs and antibodies which bind to the HBGFs of the invention are provided. The HBGF polypeptides axe useful in methods for the induction of bone, cartilage and tissue formation, growth and development of the endometrium and in the acceleration of wound healing.
    Type: Application
    Filed: February 28, 2011
    Publication date: June 30, 2011
    Inventors: David R. Brigstock, Paul A. Harding
  • Antibodies to heparin-binding growth factor (HBGF) polypeptides
    Patent number: 7897732
    Abstract: Substantially pure heparin-binding growth factor polypeptides (HBGFs), nucleic acids encoding the HBGFs and antibodies which bind to the HBGFs of the invention are provided. The HBGF polypeptides are useful in methods for the induction of bone, cartilage and tissue formation, growth and development of the endometrium and in the acceleration of wound healing.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: March 1, 2011
    Assignee: Childrens Hospital Research Foundation
    Inventors: David R. Brigstock, Paul A. Harding
  • Unique Integrin Binding Site in Connective Tissue Growth Factor
    Publication number: 20080125352
    Abstract: The invention relates to a connective tissue growth factor peptide that encompasses a CTGF binding site for an integrin such as ?v?3 or ?5?1 and uses therefor. The invention also relates to agonists and inhibitors of the CTGF-integrin binding and methods of treating and preventing CTGF-related disorders.
    Type: Application
    Filed: November 15, 2007
    Publication date: May 29, 2008
    Applicant: NATIONWIDE CHILDREN'S HOSPITAL
    Inventors: David R. Brigstock, Runping Gao
  • HEPARIN-BINDING GROWTH FACTOR (HBGF) POLYPEPTIDES
    Publication number: 20010007019
    Abstract: Substantially pure heparin-binding growth factor polypeptides (HBGFs), nucleic acids encoding the HBGFs and antibodies which bind to the HBGFs of the invention are provided. The HBGF polypeptides are useful in methods for the induction of bone, cartilage and tissue formation, growth and development of the endometrium and in the acceleration of wound healing.
    Type: Application
    Filed: July 9, 1998
    Publication date: July 5, 2001
    Applicant: CHILDREN'S HOSPITAL RESEARCH FOUNDATION
    Inventors: DAVID R. BRIGSTOCK, PAUL A. HARDING
  • Heparin-binding growth factor (HBGF) polypeptides
    Patent number: 5876730
    Abstract: Substantially pure heparin-binding growth factor polypeptides (HBGFs), nucleic acids encoding the HBGFs and antibodies which bind to the HBGFs of the invention are provided. The HBGF polypeptides are useful in methods for the induction of bone, cartilage and tissue formation, growth and development of the endometrium and in the acceleration of wound healing. HBGF is related to Connective Tissue Growth Factor (CTGF).
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: March 2, 1999
    Assignee: Childrens Hospital Research Foundation
    Inventors: David R. Brigstock, Paul A. Harding