Abstract: This disclosure relates generally to inhibitors of MHC-I downmodulation, and methods of treating or preventing an HIV infection by administering the inhibitors to a patient in need of treatment thereof.

Abstract: A thermal metal spraying apparatus for applying a metal coating to a target surface. The apparatus provides a cathode, a wire feed stock having a free end, and a wire guide that directs the free end of the wire feedstock to a position for establishing and maintaining a plasma transferred wire arc between the cathode and the free end of the wire feedstock. The wire guide maintains at least three points of contact with the wire feedstock as the wire feedstock is fed through the wire guide.

Abstract: A thermal metal spraying apparatus for applying a metal coating to a target surface. The apparatus provides a cathode, a wire feed stock having a free end, and a wire guide that directs the free end of the wire feedstock to a position for establishing and maintaining a plasma transferred wire arc between the cathode and the free end of the wire feedstock. The wire guide maintains at least three points of contact with the wire feedstock as the wire feedstock is fed through the wire guide.

Abstract: A high performance computing system with a plurality of computing blades has at least one computing blade that includes one or more computing boards and two side rails disposed at either side of the computing board. Each side rail has a board alignment element configured to hold the computing board within the computing blade, so that a top of the computing board is coupled to, and adjacent to, a portion of the board alignment element.

Abstract: A cooling system for a high performance computing system includes a closed-loop cooling cell having two compute racks and a cooling tower between the compute racks. Each compute rack includes at least one blade enclosure, and the cooling tower includes at least one water-cooled heat exchanger and one or more blowers configured to draw warm air from a side of the compute racks towards a back, across the water-cooled heat exchanger, and to circulate cooled air to a side of the compute racks towards a front. The cooling cell further includes a housing enclosing the compute racks and the cooling tower to provide a closed-loop air flow within the cooling cell. The cooling system further includes cooling plate(s) configured to be disposed between two computing boards within the computing blade, and a fluid connection coupled to the cooling plate and in fluid communication with the blade enclosure.

Abstract: A high performance computing (HPC) system includes computing blades having a first region that includes processors for performing a computation, and a second region that includes non-volatile memory for use in performing the computation and another computing processor for performing data movement and storage. Because data movement and storage are offloaded to the secondary processor, the processors for performing the computation are not interrupted to perform these tasks. A method for use in the HPC system receives instructions in the computing processors and first data in the memory. The method includes receiving second data into the memory while continuing to execute the instructions in the computing processors, without interruption. A computer program product implementing the method is also disclosed.

Abstract: A high performance computing system includes one or more blade enclosures configured to hold a plurality of computing blades, a connection interface, coupled to the one or more blade enclosures, having one or more connectors and a shared power bus that distributes power to the one or more blade enclosures, and at least one power shelf removably coupled to the one or more connectors and configured to hold one or more power supplies. The system may further include the computing blades and the power supplies. The power shelf may include a power distribution board configured to connect the power supplies together on the shared power bus.

Abstract: A high performance computing (HPC) system includes computing blades having a first region that includes processors for performing a computation, and a second region that includes non-volatile memory for use in performing the computation and another computing processor for performing data movement and storage. Because data movement and storage are offloaded to the secondary processor, the processors for performing the computation are not interrupted to perform these tasks. A method for use in the HPC system receives instructions in the computing processors and first data in the memory. The method includes receiving second data into the memory while continuing to execute the instructions in the computing processors, without interruption. A computer program product implementing the method is also disclosed.

Abstract: A high performance computing system includes one or more blade enclosures configured to hold a plurality of computing blades, a connection interface, coupled to the one or more blade enclosures, having one or more connectors and a shared power bus that distributes power to the one or more blade enclosures, and at least one power shelf removably coupled to the one or more connectors and configured to hold one or more power supplies. The system may further include the computing blades and the power supplies. The power shelf may include a power distribution board configured to connect the power supplies together on the shared power bus.

Abstract: A cooling system for a high performance computing system includes a closed-loop cooling cell having two compute racks and a cooling tower between the compute racks. Each compute rack includes at least one blade enclosure, and the cooling tower includes at least one water-cooled heat exchanger and one or more blowers configured to draw warm air from a side of the compute racks towards a back, across the water-cooled heat exchanger, and to circulate cooled air to a side of the compute racks towards a front. The cooling cell further includes a housing enclosing the compute racks and the cooling tower to provide a closed-loop air flow within the cooling cell. The cooling system further includes cooling plate(s) configured to be disposed between two computing boards within the computing blade, and a fluid connection coupled to the cooling plate and in fluid communication with the blade enclosure.

Abstract: A high performance computing system with a plurality of computing blades has at least one computing blade that includes one or more computing boards and two side rails disposed at either side of the computing board. Each side rail has a board alignment element configured to hold the computing board within the computing blade, so that a top of the computing board is coupled to, and adjacent to, a portion of the board alignment element.

Abstract: A rack including a rail for supporting a computer module and a grounding element electrically coupled to the rack and positioned to electrically contact a computer module inserted in the rack such that the grounding element provides a path to ground. The grounding element can be an arcuate bracket attached to the rail to make contact with a side of the computer module. The grounding element can be a conductor extending from the rack and positioned to make contact with a side of the computer module. The rack can include a wider section which provides a cabling channel and a member on the rack for mechanically coupling the rack to an adjacent rack. The rack can include at least one passage for allowing a cable to pass through the rack to an adjacent rack and a cable organizer for maintaining placement of at least one cable routed through the passage.

Abstract: A folding chair includes collapsible rungs permitting folding in two directions. Stability is further enhanced by the upholstery which further forces the top rung of the chair downward making the chair rigid in the open position. Side rails and back supports slide freely along the chair's rear legs creating a folding mechanism that folds the seat upwards while also pulling the rear leg upwards in the same direction resulting in greater stability without increasing the height of the folded package.

Abstract: A method of integrating wear plates into a spray formed rapid tool includes the steps of making a model of a desired tool and constructing a ceramic pattern as the inverse of the model. The method also includes the steps of locating at least one wear plate on the ceramic pattern and thermally spraying a metal material against the wear plate and ceramic pattern to form the desired tool and embedding the wear plate into the desired tool.

Abstract: A method of integrating detailed features into a spray formed rapid tool includes the steps of making a model of a desired tool and constructing a ceramic pattern as the inverse of the model. The method also includes the steps of locating at least one detailed feature insert on the ceramic pattern and thermally spraying metal material against the detailed feature insert and ceramic pattern to form the desired tool and embedding the detailed feature insert into the desired tool.

Abstract: An article of footwear, such as a soccer boot (1) or training shoe has a sole (5) incorporating a stiffener (8;22,23) . The stiffener comprises a first portion (10;22) which stiffens the waist or shank of the sole and so resists transverse flexure, and a second portion (11;23) which both stiffens the fore-part of the sole and provides resilience to cause or assist in returning the fore-part of the sole to its original shape after it has been subjected, in use, to transverse flexure as the result of flexure of the wearer's foot at the ball of the foot. The stiffness of the second portion is less than the stiffness of the first portion. The stiffening (8) may be formed as a unitary body, with the forward end of the first portion integral with or united with the rear end of the second portion.

Abstract: A high solids structured kaolin clay slurry having improved high shear rheology is manufactured by a process which comprises the sequential steps of forming an aqueous composition by mixing water and a lithium-based dispersant and then mixing structured kaolin clay particles with the aqueous composition to form the desired high solids slurry.