Abstract: Gene expression can be selectively regulated by endogenous miRNAs that target promoters of genes. Altering of the activity of these promoter-targeting miRNAs with single-stranded complementary oligonucleotides that bind the miRNA causes modulation of expression of the target gene. Endogenous miRNAs that modulate expression of target genes can be identified by (a) evaluating an endogenous miRNA for complementarity to a target gene promoter; and (b) determining that the complementary miRNA modulates expression of the target gene.

Abstract: The present invention relates to the inhibition of p53 transcription by interfering with the activity of a p53 promoter using inhibitory double-stranded RNAs. Use of these inhibitory RNAs in the treatment of cancers also is disclosed.

Abstract: Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.

Abstract: The invention relates to peptide nucleic acids that inhibit telomerase activity in mammalian cells.

Abstract: The invention relates to peptide nucleic acids that inhibit telomerase activity in mammalian cells.

Abstract: The invention relates to peptide nucleic acids that modulate telomerase activity in mammalian cells.

Abstract: A filtered coaxial connector is provided including an insulated housing, a conductive connector shell concentrically surrounding a center conductor, a ferrite cylinder concentrically located around a portion of the conductive shell and a leadless chip capacitor, one contact of which is electrically connected to the conductive shell. A solid metal washer is electrically connected with the second contact of the chip capacitor. When installed in an enclosure, the metal washer is additionally in contact with the enclosure panel, connecting the capacitor between the connector shell and the enclosure panel. Electrically, the ferrite cylinder is connected in series with the capacitor, thus forming an impedance divider. Common-mode noise generated within the enclosure is applied to this impedance divider, and is shunted through the capacitor to the chassis. As such, common-mode noise generated within the enclosure is attenuated before being permitted to spread throughout the network, via an attached coaxial cable.