Patents by Inventor David R. Cox
David R. Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090186347Abstract: Correlations between polymorphisms and metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Methods of diagnosing and treating metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Systems and kits for diagnosis and treatment of metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided.Type: ApplicationFiled: May 9, 2008Publication date: July 23, 2009Inventors: David R. Cox, Kelly A. Frazer, David A. Hinds, Craig L. Hyde, John F. Thompson
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Publication number: 20090092262Abstract: One embodiment of the present invention provides a system that manages the acoustic noise produced by a device. During operation, the system receives a set of acoustic characteristics for the device. The system then uses these acoustic characteristics to estimate the acoustic noise being generated by the device. Next, the system uses the estimated acoustic noise to adjust a setting in the device to manage the acoustic noise produced by the device.Type: ApplicationFiled: October 4, 2007Publication date: April 9, 2009Applicant: APPLE INC.Inventors: Paul J. Costa, David R. Cox, Benjamin A. Bard
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Publication number: 20090087854Abstract: Methods of treating an individual exhibiting a medical condition are disclosed. The methods involve determining a score of an individual based on the individual's genotypic information, comparing the score to at least one threshold value, wherein the result of the comparison is indicative of a beneficial response to a treatment, and providing a suitable treatment to the individual.Type: ApplicationFiled: September 23, 2008Publication date: April 2, 2009Applicant: Perlegen Sciences, Inc.Inventors: David R. Cox, Mark A. McCamish
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Publication number: 20080303946Abstract: A system that displays a video signal on a display for a computer system is presented. During operation, the system receives a signal to switch from displaying a video signal from an internal video source to displaying a video signal from an external video source. In this system, the internal and external video sources are coupled to a bi-directional video port for the computer system, wherein the internal video source generates an output video signal and the external video source generates an input video signal. The system then determines whether the external video source is coupled to the bi-directional video port. If so, the system couples the external video source to the display and determines whether the external video source is a valid video source. If the external video source is a valid video source, the system displays the video signal from the external video source on the display.Type: ApplicationFiled: June 6, 2007Publication date: December 11, 2008Inventors: David R. Cox, Derek J. DiCarlo, Paul J. Costa
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Publication number: 20080299125Abstract: The invention provides a collection of polymorphic sites associated with response to treatment by an SSRI or placebo in depression patients. The polymorphic sites and others in linkage disequilibrium with them are useful in determining whether to treat a patient with an SSRI or include a patient in a clinical trial to test an SSRI.Type: ApplicationFiled: June 5, 2007Publication date: December 4, 2008Applicant: Perlegen Sciences, Inc.Inventors: David A. Hinds, David R. Cox, Craig L. Hyde, Hakan Sakul
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Patent number: 7427480Abstract: Improved life sciences business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic developments.Type: GrantFiled: July 13, 2005Date of Patent: September 23, 2008Assignee: Perlegen Sciences, Inc.Inventors: Bradley A Margus, David R Cox
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Patent number: 7204059Abstract: Removable door jamb assembly guard, guarded jamb assembly, and methods of controlling a doorway. The guard preferably covers the full length of the jamb assembly, and the full width of the jamb assembly between an outer trim element and the door-arresting surface. The guard has a central section, a door leg section, an outer leg section disposed outwardly of the central section, and optionally a transition section between the central section and the outer leg section. Preferred embodiments of the guard can be installed on a jamb assembly while a conventional door slab is mounted to the jamb assembly, and the door slab can be closed and opened without the guard interfering with such operation of the door slab.Type: GrantFiled: July 8, 2003Date of Patent: April 17, 2007Assignee: Custom Millworking, Inc.Inventors: Glenn P. Schiffmann, David R. Cox
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Patent number: 7153652Abstract: Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and-lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.Type: GrantFiled: February 20, 2002Date of Patent: December 26, 2006Assignees: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of CaliforniaInventors: David R. Cox, Malek Faham, Siamak Baharloo
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Patent number: 7135286Abstract: Improved pharmaceutical and diagnostic business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic development.Type: GrantFiled: March 26, 2002Date of Patent: November 14, 2006Assignee: Perlegen Sciences, Inc.Inventors: Bradley A. Margus, David R. Cox, Stephen P. A. Fodor
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Patent number: 7115726Abstract: The present invention includes the use of any of the polymorphisms, SNP haplotype blocks or SNP haplotype patterns. In one embodiment, susceptibility to a phenotype resulting from an allele or marker in linkage disequilibrium with such polymorphic forms is evaluated. Novel therapeutic and diagnostic compounds and methods are also disclosed.Type: GrantFiled: August 22, 2002Date of Patent: October 3, 2006Assignee: Perlegen Sciences, Inc.Inventors: David R. Cox, Deana A. Arnold
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Patent number: 6969589Abstract: The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.Type: GrantFiled: March 26, 2002Date of Patent: November 29, 2005Assignee: Perlegen Sciences, Inc.Inventors: Nila Patil, David R. Cox, Anthony J. Berno, David A. Hinds
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Patent number: 6955883Abstract: Improved life sciences business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic developments.Type: GrantFiled: March 26, 2003Date of Patent: October 18, 2005Assignee: Perlegen Sciences, Inc.Inventors: Bradley A. Margus, David R. Cox, Stephen P. A. Fodor
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Patent number: 6897025Abstract: Improved systems and methods for performing genetic analyses. Full genomic DNA scans are performed on the genetic DNA from a plurality of individuals to identify genetic variants. For those variants, but not based on a full genetic DNA scan, the variants alone are scanned in additional individuals to identify blocks of the variants that tend to be inherited together.Type: GrantFiled: January 7, 2002Date of Patent: May 24, 2005Assignee: Perlegen Sciences, Inc.Inventors: David R. Cox, Bradley A. Margus, Nila Patil
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Publication number: 20040241657Abstract: Composition and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of liver related disease, inflammatory disease and related conditions are disclosed. Also provided are kits and reagents for prognosis and diagnosis of liver related disease, inflammatory disease and related conditions.Type: ApplicationFiled: May 28, 2003Publication date: December 2, 2004Applicant: Perlegen Sciences, Inc.Inventors: Nila Patil, David R. Cox, Coleen R. Hacker, David Hinds, David Kershenobich, Naiping Shen
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Publication number: 20040229224Abstract: The invention provides methods of analyzing genes for differential relative allelic expression patterns. Haplotype blocks throughout the genomes of individuals are analyzed to identify haplotype patterns that are associated with specific differential relative allelic expression patterns. Haplotype blocks that contain associated haplotype patterns may be further investigated to identify genes or variants of genes involved in differential relative allelic expression patterns.Type: ApplicationFiled: May 13, 2003Publication date: November 18, 2004Applicant: Perlegen Sciences, Inc.Inventors: Kelly A. Frazer, David R. Cox, Heng Tao, Krishna Pant, Geoffrey Nilsen
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Publication number: 20040126797Abstract: The present invention relates to a micro-array system and the uses thereof. Particularly, the micro-array system is for a micro amount of biomolecules carrying on a bioreaction in a reaction solution, which comprises a substrate comprising a plurality of micro-wells for receiving the reaction solution; a plurality of micro-beads placing in the reaction solution for the biomolecules attached on surfaces thereon; and a vibrating module for vibrating the substrate, which makes the biomolecules attached on the micro-beads react evenly. Optionally, the micro-array system further comprises a temperature control module for controlling the temperature of the reaction solution. The bioreaction performed in the micro-array system according to the invention has the advantages of having a high sensitivity, being easily post-manipulated, being easily operated, having a high reliability and being reusable.Type: ApplicationFiled: October 21, 2003Publication date: July 1, 2004Applicants: NATIONAL TSING-HUA UNIVERSITY, STANFORD UNIVERSITYInventors: Chih-Ying Hsu, Tzong-Hsiung Hseu, Ruey-Shing Huang, David R. Cox, Chien-ming Wu, Jiann Heng Chen, Min-Lung Tsai, Ming-Tsong Lai, Yong-Li Pan, Tai-ching Fan
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Publication number: 20040091890Abstract: Improved life sciences business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic developments.Type: ApplicationFiled: March 26, 2003Publication date: May 13, 2004Applicant: Perlegen Sciences, Inc.Inventors: Bradley A. Margus, David R. Cox, Stephen P.A. Fodor
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Patent number: 6709827Abstract: Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.Type: GrantFiled: February 8, 2002Date of Patent: March 23, 2004Assignees: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of CaliforniaInventors: David R. Cox, Malek Faham, Siamak Baharloo
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Publication number: 20040053232Abstract: The present invention includes the use of any of the polymorphisms, SNP haplotype blocks or SNP haplotype patterns. In one embodiment, susceptibility to a phenotype resulting from an allele or marker in linkage disequilibrium with such polymorphic forms is evaluated. Novel therapeutic and diagnostic compounds and methods are also disclosed.Type: ApplicationFiled: August 22, 2002Publication date: March 18, 2004Applicant: Perlegen Sciences, Inc.Inventors: David R. Cox, Deana A. Arnold
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Publication number: 20040029161Abstract: The present invention relates to business methods for discovery of therapeutic and diagnostic products by identifying variations that occur in the human genome, relating these variations to one another, and, ultimately, relating these variations to the genetic bases of phenotype such as disease resistance, disease susceptibility or drug response.Type: ApplicationFiled: May 30, 2003Publication date: February 12, 2004Applicant: Perlegen Sciences, Inc.Inventors: David R. Cox, Nila Patil, Anthony J. Berno, David A. Hinds