Patents by Inventor David R. Friend
David R. Friend has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230081059Abstract: Described herein are methods of reducing the risk of recurrence of bacterial vaginosis by intravaginal administration of compositions comprising L-lactic acid, polymer thickener, and preservative.Type: ApplicationFiled: August 19, 2022Publication date: March 16, 2023Inventor: David R. FRIEND
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Patent number: 11419835Abstract: Described herein are methods of reducing the risk of recurrence of bacterial vaginosis by intravaginal administration of compositions comprising L-lactic acid, polymer thickener, and preservative.Type: GrantFiled: October 3, 2017Date of Patent: August 23, 2022Assignee: Evofem, Inc.Inventor: David R. Friend
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Publication number: 20190224150Abstract: Described herein are methods of reducing the risk of recurrence of bacterial vaginosis by intravaginal administration of compositions comprising L-lactic acid, polymer thickener, and preservative.Type: ApplicationFiled: October 3, 2017Publication date: July 25, 2019Inventor: David R. FRIEND
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Publication number: 20190209502Abstract: Described herein are compositions comprising a combination of L-lactic acid and carrageenan and methods for treating or preventing HPV or other sexually transmitted infections by administering the composition.Type: ApplicationFiled: September 11, 2017Publication date: July 11, 2019Inventor: David R. Friend
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Publication number: 20160030569Abstract: The present invention relates to formulations of nucleotide reverse transcriptase inhibitors (NRTIs), preferably [2-(6-Amino-pur: in-9-yl)-1-methyl-ethoxymethy]-phosphonic acid (tenofivir, PMPA), or a physiologically functional derivative thereof, wherein the formulations contain a low level of glycerin. Human immunodeficiency vims (HIV) infection and related diseases are a major public health problem worldwide. One approach to the problem of HIV/AIDS is to reduce the risk of transmission of HIV and thus reduce the number of individuals who become newly infected.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Inventor: David R. FRIEND
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Publication number: 20040208931Abstract: A dosage unit comprises a substrate comprising a first polymer; a deposit, including an active ingredient; and a cover layer comprising a second polymer, wherein the cover layer covers the deposit and is joined to the first surface of the substrate by a bond that encircles the deposit and wherein at least one of the first and second polymers is a graft co-polymer. The dosage unit wherein said first and second polymers may be the same, and also the graft co-polymer may be a polyvinyl alcohol-polyethylene glycol graft co-polymer. Also disclosed is a dosage unit wherein the deposit is formed on the substrate by electrostatic dry drug deposition. The dosage unit may also include a polymer that is a graft co-polymer; and an active ingredient, and the graft co-polymer may be polyvinyl alcohol-polyethylene glycol.Type: ApplicationFiled: December 23, 2003Publication date: October 21, 2004Inventors: David R. Friend, Aaron W. Levine, Kerrie L. Ziegler, Emmanuel Manna
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Patent number: 6355270Abstract: Microfabricated, asymmetrical, reservoir-containing particles for use in the oral delivery of biopolymer therapeutic agents such as peptides, proteins and oligonucleotides are disclosed. The particles are encapsulated in enteric-coated capsules or tablets to provide passage through the stomach and release of a suspension of the particles in the intestinal lumen. The particles have a selected shape, and uniform dimensions preferably in the 100 &mgr;m to 1 mm range. The reservoirs open to the face of the particle and are filled with a therapeutic agent and selected excipients. The excipients are selected to delay the dissolution/release of the agent from the particle reservoirs for 5-60 minutes after the particle is released in the intestinal lumen. Alternatively, the pore is plugged with an erodable material.Type: GrantFiled: January 6, 2000Date of Patent: March 12, 2002Assignee: The Regents of the University of CaliforniaInventors: Mauro Ferrari, Peter J. Dehlinger, Francis J. Martin, Carl F. Grove, David R. Friend
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Patent number: 6139865Abstract: A taste-masked microcapsule composition for administration of a drug is provided. The composition comprises microcapsules of drug and a substantially water-insoluble polymeric material, typically a cellulosic polymer. The microcapsule composition may be incorporated into any number of pharmaceutical formulations, including chewable tablets, effervescent tablets, powders, liquid dispersions, and the like. A method for masking the taste of drugs is also provided, involving a phase separation coacervation technique in which drug is coated with relatively high levels of a polymeric material. These high coating levels give rise to effective taste masking, while nevertheless allowing targeted release of drug, so that the drug is released shortly after passage through the mouth.Type: GrantFiled: October 1, 1997Date of Patent: October 31, 2000Assignee: Eurand America, Inc.Inventors: David R. Friend, Steve Ng, Rafael E. Sarabia, Thomas P. Weber, Jean-Marie Geoffroy
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Patent number: 6063402Abstract: Disclosed is a substantially anhydrous, powdered, galactomannan composition consisting essentially of a galactomannan hydrocolloid exhibiting about 50% to about 90% by weight of anhydromannose residues and about 10% to about 50% by weight anhydrogalactose residues; less than about 1% by weight of protein material and less than about 3% of other nonaqueous impurities. This material is useful for preparing pharmaceutical compositions both in the substantially anhydrous form but preferably in an anhydrated form which includes about 5-15% by weight water. The pharmaceutical compositions comprise a therapeutically effective amount of a drug, the hydrated powered gallactomannan composition and optionally other pharmaceutically-acceptable excipients. When the hydrated powdered purified glactomannan of the invention is used to form a tablet, one sees improved hardness in the tablet formed.Type: GrantFiled: June 7, 1995Date of Patent: May 16, 2000Assignee: Venture Lending, A Division of Cupertino National BankInventors: Mark S. Gebert, David R. Friend, David Wong, Jagdish Parasrampuria
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Patent number: 5993860Abstract: An oral-delivery pharmaceutical composition for reducing the gastric irritation effect of an NSAID in the upper GI tract of a mammal. The composition includes (a) a mucosal protective amount of a pharmaceutically-acceptable hydrocolloid gum obtainable from higher plants, (b) a dispersion-enhancing amount of another excipient and (c) a therapeutically-effective amount of an NSAID. Also disclosed is a process for preparing the composition and a method for reducing the gastric irritation effect of the NSAID by administering the composition. Also, disclosed is a composition particularly useful for preparing an aqueous suspension.Type: GrantFiled: November 13, 1997Date of Patent: November 30, 1999Assignee: Venture LendingInventors: Eric H. Kuhrts, David R. Friend, Karen Yu, Jagdish Parasrampuria
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Patent number: 5811388Abstract: Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition are described. The composition is a unit dosage in the form of a tablet that comprises about 0.01% by weight to about 10% by weight of the drug that is useful in treating a colonic disorder or that is absorbed from the colon; about 40% by weight to about 98% by weight of a hydrocolloid gum obtainable from higher plants; and about 2% by weight to about 50% by weight of a pharmaceutically acceptable binder. The compositions are useful for treating lower GI disorders in human subjects by administering a suitable amount to a subject in need thereof. A particularly preferred aspect is the process for preparing such composition in the form of a tablet.Type: GrantFiled: February 16, 1996Date of Patent: September 22, 1998Assignee: Cibus Pharmaceutical, Inc.Inventors: David R. Friend, David Wong
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Patent number: 5656294Abstract: Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition are described. The composition comprises about 0.5% by weight to about 10% by weight of the drug that is useful in treating a colonic disorder or that is absorbed from the colon; about 40% by weight to about 80% by weight of a hydrocolloid gum obtainable from higher plants; and about 10% by weight to about 50% by weight of a pharmaceutically acceptable binder. The compositions are useful for treating colon disorders in human subjects by administering a suitable amount to a subject in need thereof. A particularly preferred aspect is the process for preparing such composition in the form of a tablet.Type: GrantFiled: June 7, 1995Date of Patent: August 12, 1997Assignee: Cibus Pharmaceutical, Inc.Inventors: David R. Friend, David Wong
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Patent number: 5238933Abstract: Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The compositions contain a lower aliphatic ester of a lower aliphatic carboxylic acid such as ethyl acetate and a lower alkanol such as propylene glycol. Methods and transdermal drug delivery systems for using the compositions are also provided.Type: GrantFiled: April 2, 1992Date of Patent: August 24, 1993Assignee: SRI InternationalInventors: Paul G. Catz, David R. Friend, Harold W. Nolen, III
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Patent number: 5112541Abstract: Microencapsulating lubricating fluids and additives and a method of preparing microencapsulated lubricants including the steps of preparing an emulsification medium, adding a lubricant to the emulsification medium, emulsifying the emulsification medium and lubricant to form an emulsion, adding a first solution including resorcinol and dimethylol urea to the emulsion, acidifying the first solution and emulsion, adding a second solution consisting of resorcinol and dimethylol urea to the acidified first solution and emulsion while vigorously stirring it to form a microcapsule suspension, adjusting the pH to be basic, filtering and washing the microcapsule suspension to separate the microcapsules from the solution, and drying the microcapsules.Type: GrantFiled: January 29, 1988Date of Patent: May 12, 1992Assignee: Idemitsu Kosan Company, Ltd.Inventor: David R. Friend
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Patent number: 5091122Abstract: A method of preparing microencapsulated basic solutions including the steps of preparing a polymer which is hydrophobic at high pH values, preparing a basic solution, dissolving the polymer in an organic solvent, adding a surfactant to the polymer solution, adding the basic solution to the dissolved polymer, emulsifying the basic solution and dissolved polymer and spray drying the emulsion while stirring the emulsion.Type: GrantFiled: March 24, 1988Date of Patent: February 25, 1992Assignee: Idemitsu Kosan Company, Ltd.Inventor: David R. Friend