Patents by Inventor David R. Harder

David R. Harder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and uses of leukotriene Bhydroxylases to treat diseases
    Patent number: 7341990
    Abstract: Methods and uses are described for treating or preventing diseases of humans or non-human animals by reducing the amount of active leukotriene B4 (LTB4) in those in need of such treatment using LTB4 hydroxylases. In certain embodiments, LTB4 hydroxylase is administered in combination with nicotinamide adenine dinucleotide phosphate and/or an NADPH-cytochrome P-450 reductase. The invention is particularly useful for treating or preventing respiratory diseases that are caused or exacerbated by inflammation.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: March 11, 2008
    Inventors: David R. Harder, James B. Antczak, Lane Brostrom
  • Use of 20-HETE synthesizing enzyme inhibitors as therapy for cerebral vascular disease
    Patent number: 7307101
    Abstract: A method for treating cerebral vascular diseases in a human or non-human animal is disclosed. The method involves inhibiting 20-HETE synthesizing enzyme activity sufficiently to increase or prevent a decrease in cerebral blood flow in the human or non-human animal.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: December 11, 2007
    Assignees: MCW Research Foundation, Inc., Taisho Pharmaceutical Co., Ltd.
    Inventors: Richard J. Roman, David R. Harder, Noriyuki Miyata, Masakazu Sato, Kazuya Kameo, Shigeru Okuyama
  • 20-HETE antagonists and agonists
    Patent number: 6605641
    Abstract: 20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z), 8(Z), 11(Z), 14(Z)-tetraenoic acid, 20-hydroxyeicosa-5(Z), 14(Z)-dienoic acid and 20-, 21-dimethyl 20-HETE. Preferable 20-HETE antagonists include 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, 19-hydroxynonadeca-5(Z), 8(Z), 11(Z), 14(Z)-tetraenoic acid and 20-hydroxyeicosa 6(Z), 15(Z)-dienoic acid.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: August 12, 2003
    Assignee: MCW Research Foundation
    Inventors: Richard J. Roman, John R. Falck, Magdalena Alonso-Galicia, Elizabeth R. Jacobs, David R. Harder
  • 20-Hete antagonists and agonists
    Patent number: 6596769
    Abstract: 20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid, 20-hydroxyeicosa-5(Z),4(Z)-dienoic acid and 20-,21-dimethyl 20-HETE. Preferable 20-HETE antagonists include 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, 19-hydroxynonadeca-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid and 20-hydroxyeicosa 6(Z),15(Z)-dienoic acid.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: July 22, 2003
    Assignee: MCW Research Foundation
    Inventors: Richard J. Roman, John R. Falck, Magdalena Alonso-Galicia, Elizabeth R. Jacobs, David R. Harder
  • 20- Hete antagonists and agonists
    Publication number: 20020072534
    Abstract: 20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid, 20-hydroxyeicosa-5(Z),4(Z)-dienoic acid and 20-,21-dimethyl 20-HETE. Preferable 20-HETE antagonists include 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, 19-hydroxynonadeca-5(Z),8(Z),ll(Z),14(Z)-tetraenoic acid and 20-hydroxyeicosa 6(Z),15(Z)-dienoic acid.
    Type: Application
    Filed: December 14, 2001
    Publication date: June 13, 2002
    Inventors: Richard J. Roman, John R. Falck, Magdalena Alonso-Galicia, Elizabeth R. Jacobs, David R. Harder
  • 20-HETE antagonists and agonists
    Patent number: 6395781
    Abstract: 20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid, 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid and 20-,21-dimethyl 20-HETE. Preferable 20-HETE antagonists include 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, 19-hydroxynonadeca-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid and 20-hydroxyeicosa 6(Z),15(Z)-dienoic acid.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: May 28, 2002
    Assignee: MCW Research Foundation
    Inventors: Richard J. Roman, John R. Falck, Magdalena Alonso-Galicia, Elizabeth R. Jacobs, David R. Harder
  • 20-HETE antagonists and agonists
    Publication number: 20020049244
    Abstract: 20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z), 8(Z),11(Z),14(Z)-tetraenoic acid, 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid and 20-,21-dimethyl 20-HETE. Preferable 20-HETE antagonists include 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, 19-hydroxynonadeca-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid and 20-hydroxyeicosa 6(Z),15(Z)-dienoic acid.
    Type: Application
    Filed: December 14, 2001
    Publication date: April 25, 2002
    Inventors: Richard J. Roman, John R. Falck, Magdalena Alonso-Galicia, Elizabeth R. Jacobs, David R. Harder
  • Quick connect/disconnect pipe coupling
    Patent number: 5297819
    Abstract: A quick connect/disconnect pipe coupling comprising a female receptacle member, a locking collar adapted to be slidably engaged over one end of the female receptacle member, and a male plug member adapted to be inserted into the collar engaged female receptacle member to form a tight connection therebetween. The collar includes radial locking flanges for engaging cooperating annular ridges on the plug and receptacle members, respectively. Slidable movement of the collar toward the receptacle member disengages the locking flange on the collar from the annular ridge on the male plug member thereby enabling a quick disconnect of the female receptacle member and collar from the male plug member.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: March 29, 1994
    Inventor: David R. Harder
  • Method of treatment and prevention of cerebral vasospasms
    Patent number: 4792564
    Abstract: A method is disclosed for preventing or treating cerebral vasospasms such as those which usually follow subarachnoid hemorrhage. The method comprises administering to the animal a safe and effective amount of nicorandil to prevent or treat the vasospasm.
    Type: Grant
    Filed: August 28, 1986
    Date of Patent: December 20, 1988
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: David R. Harder, John G. Gross