Patents by Inventor David R. Hinton

David R. Hinton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200077641
    Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
    Type: Application
    Filed: August 30, 2019
    Publication date: March 12, 2020
    Applicants: University of Southern California, The Regents of the University of California
    Inventors: Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Arnold, Lincoln V. Johnson, Dennis O. Clegg, Mark S. Humayun, David R. Hinton, Danhong Zhu, Debbie Mitra
  • Publication number: 20200045957
    Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
    Type: Application
    Filed: October 21, 2019
    Publication date: February 13, 2020
    Applicant: University of Southern California
    Inventors: Danhong Zhu, David R. Hinton, Ashish Ahuja, Mark S. Humayun
  • Publication number: 20190151499
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Application
    Filed: December 17, 2018
    Publication date: May 23, 2019
    Applicants: University of Southern California, California Institute of Technology, The Regents of the University of California
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita
  • Patent number: 10246682
    Abstract: The production of high quality retinal pigmented epithelium (RPE) cells is necessary for research and potential therapeutic uses. Especially desirable are methods for the production of RPE cells using xeno-free culture conditions. Disclosed herein are novel methods for the production of RPE cells from pluripotent cells with high yields, including xeno-free production methods. Also provided are methods of efficiently isolating RPE cells from cultures containing heterogeneous cell types, allowing for substantially pure RPE cell cultures to be established. Additionally, novel methods for the cryopreservation of RPE cells are provided.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: April 2, 2019
    Assignees: The Regents of the University of California, University of Southern California
    Inventors: Dennis Clegg, Sherry T. Hikita, Lincoln V. Johnson, Liane Miller, Marlene Tsie, Chelsea D. Presbrey, Lisa R. Conti, Michelle A. Maloney, David R. Hinton, Qirui Hu
  • Patent number: 10188769
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: January 29, 2019
    Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, CALIFORNIA INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita
  • Publication number: 20030153524
    Abstract: The present invention relates to methods for inhibiting or preventing ocular processes associated with CTGF. Methods and agents for use in treating or preventing ocular disorders, methods for diagnosing ocular disorders and related kits, and methods for screening for agents for use in the present methods are also provided.
    Type: Application
    Filed: December 11, 2002
    Publication date: August 14, 2003
    Inventors: David R. Hinton, Shikun He, Noelynn A. Oliver
  • Patent number: 6588539
    Abstract: A wheel and final drive assembly for a work machine, such as a mining truck, having a driven rotatable wheel having inboard and outboard rims mounted thereto. The final drive assembly including a first and a second reduction gear assembly. A carrier output adapter having an inboard end, an outboard end, a cover attached to the outboard end and a mounting surface. The carrier adapter being attached at the inboard mounting surface to a outboard rim mounting ring and at the cover to a carrier assembly of the second reduction gear assembly.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: July 8, 2003
    Assignee: Caterpillar Inc
    Inventors: David R. Hinton, Keith A. Kabrick
  • Patent number: 6588538
    Abstract: A wheel and final drive assembly for a work machine, such as a mining truck, having a driven rotatable wheel having inboard and outboard rims mounted thereto. The final drive assembly including a first and a second reduction gear assembly. A ring gear adapter having an inboard end, an outboard end, and an inner surface, a plurality of teeth disposed about the inner surface and interacting with a plurality of planetary gears of the first and second gear reduction assemblies and the inboard end of the ring gear adapter removably coupled to the outboard flange of the wheel.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: July 8, 2003
    Assignee: Caterpillar Inc.
    Inventors: David R. Hinton, Keith A. Kabrick
  • Patent number: 6550588
    Abstract: A brake assembly for braking a wheel having a brake anchor, a brake anchor first annular portion, a brake anchor second annular portion, and a plurality of brake anchor splines on the brake anchor first annular portion.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: April 22, 2003
    Assignee: Caterpillar Inc
    Inventors: David R. Hinton, Michael A. Lopez
  • Publication number: 20030010564
    Abstract: A wheel and final drive assembly for a work machine, such as a mining truck, having a driven rotatable wheel having inboard and outboard rims mounted thereto. The final drive assembly including a first and a second reduction gear assembly. A ring gear adapter having an inboard end, an outboard end, and an inner surface, a plurality of teeth disposed about said inner surface and interacting with a plurality of planetary gears of the first and second gear reduction assemblies and said inboard end of said ring gear adapter removably coupled to said outboard flange of said wheel.
    Type: Application
    Filed: July 12, 2001
    Publication date: January 16, 2003
    Inventors: David R. Hinton, Keith A. Kabrick
  • Publication number: 20030010578
    Abstract: A brake assembly for braking a wheel having a brake anchor, a brake anchor first annular portion, a brake anchor second annular portion, and a plurality of brake anchor splines on the brake anchor first annular portion.
    Type: Application
    Filed: July 10, 2001
    Publication date: January 16, 2003
    Inventors: David R. Hinton, Michael A. Lopez
  • Publication number: 20030010549
    Abstract: A wheel and final drive assembly for a work machine, such as a mining truck, having a driven rotatable wheel having inboard and outboard rims mounted thereto. The final drive assembly including a first and a second reduction gear assembly. A carrier output adapter having an inboard end, an outboard end, a cover attached to the outboard end and a mounting surface. The carrier adapter being attached at the inboard mounting surface to a outboard rim mounting ring and at the cover to a carrier assembly of the second reduction gear assembly.
    Type: Application
    Filed: July 12, 2001
    Publication date: January 16, 2003
    Inventors: David R. Hinton, Keith A. Kabrick
  • Patent number: 6485389
    Abstract: A mechanical differential assembly having an increased bearing load zone capacity. The mechanical gear assembly maintains a proper load capacity of rollers of the bearings which support a differential gear assembly. The mechanical differential assembly thus maintains alignment of the inner and outer races of the bearings regardless of an axial force placed on the bearings, any loads placed on the differential gear assembly or the like during driving condition. The mechanical differential assembly includes a differential gear assembly supported on a first end by a cylindrical bearing and supported on the second end by a pair of tapered bearings.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: November 26, 2002
    Assignee: Caterpillar Inc.
    Inventors: Douglas W. Bell, David R. Hinton, Marcus D. Bunnow
  • Patent number: 6457502
    Abstract: This invention relates to a method and apparatus for maintaining equal air pressure in a pair of tires on a work machine. The invention provides a valve body with a pair of piston chambers. A piston is reciprocatably positioned within each piston chamber, the pistons are biased toward a first closed end of the piston chambers. The closed end of each piston chamber is connected by a passageway to one of the tires. Each piston chamber is additionally fluidly connected to the other piston chamber. When the air pressure in each tire is above a predetermined amount the pistons are moved away from the closed end of the piston chamber and airflow is permitted between the piston chambers thereby balancing the tire pressures. If the pressure in either tire is below the predetermined minimum, the piston in that respective piston chamber moves toward the first end to block, airflow between the piston chambers.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: October 1, 2002
    Assignee: Caterpillar Inc
    Inventors: Douglas W. Bell, David W. Bruce, Jon R. Greiner, David R. Hinton
  • Publication number: 20020074069
    Abstract: This invention relates to a method and apparatus for maintaining equal air pressure in a pair of tires on a work machine. The invention provides a valve body with a pair of piston chambers. A piston is reciprocatably positioned within each piston chamber, the pistons are biased toward a first closed end of the piston chambers. The closed end of each piston chamber is connected by a passageway to one of the tires. Each piston chamber is additionally fluidly connected to the other piston chamber. When the air pressure in each tire is above a predetermined amount the pistons are moved away from the closed end of the piston chamber and airflow is permitted between the piston chambers thereby balancing the tire pressures. If the pressure in either tire is below the predetermined minimum, the piston in that respective piston chamber moves toward the first end to block, airflow between the piston chambers.
    Type: Application
    Filed: December 15, 2000
    Publication date: June 20, 2002
    Inventors: Douglas W. Bell, David W. Bruce, Jon R. Greiner, David R. Hinton
  • Patent number: 6360840
    Abstract: An apparatus for controlling temperature of fluid in a rear axle assembly includes a rear axle housing having an internal component chamber. The internal component chamber has a rear axle sump located therein. The apparatus also includes a temperature control operational pressure source coupled to the internal component chamber. The apparatus further includes a diverter valve coupled to the temperature control operational pressure source. The apparatus includes a heating fluid return line interposed between the diverter valve and the rear axle sump, and includes a cooling fluid return line interposed between the diverter valve and the rear axle housing. The temperature control operational pressure source is selectively operable between (i) a first rate mode in which it advances fluid from the internal component chamber at a first flow rate, and (ii) a second rate mode in which it advances fluid from the internal component chamber at a second flow rate.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: March 26, 2002
    Assignee: Caterpillar Inc.
    Inventors: Douglas W. Bell, David W. Bruce, David R. Hinton
  • Patent number: 6247233
    Abstract: A wheel assembly for a work machine, such as a mining dump truck, comprises a rotatable wheel having inboard and outboard rims mounted thereto. The outboard rim is mounted to a segmented rim-mounting flange which is secured to the inboard side of a flange projecting from the wheel. A final drive adapter is secured to the outboard end of the wheel opposite the segmented rim mounted flange. The segmented mounting flange permits the use of a larger final drive ring gear than in known wheel assemblies. Moreover, because the mounting flange is segmented, it can be fastened to the wheel inboard of the gear reduction housing, which permits the final drive assembly to be serviced without removal of the outboard rim from the wheel. Related methods are also disclosed.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: June 19, 2001
    Assignee: Caterpillar Inc.
    Inventors: David R. Hinton, Eric A. Morr, Thomas J. Suelflow
  • Patent number: 6148941
    Abstract: A wheel assembly for a work machine, such as a mining dump truck, having a rotatable wheel having inboard and outboard rims mounted thereto. The outboard rim is mounted to a segmented rim-mounting flange which is secured to the inboard side of a flange projecting from the wheel. A final drive adapter is secured to the outboard end of the wheel opposite the segmented rim mounted flange. The segmented mounting flange permits the use of a larger final drive ring gear than in known wheel assemblies. Moreover, because the mounting flange is segmented, it can be fastened to the wheel inboard of the gear reduction housing, which permits the final drive assembly to be serviced without removal of the outboard rim from the wheel.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: November 21, 2000
    Assignee: Caterpillar Inc.
    Inventors: David R. Hinton, Eric A. Morr, Thomas J. Suelflow
  • Patent number: 5584773
    Abstract: In the operation of modern day construction machinery, especially those of relatively large size, it is a common occurrence for the bearings in the axle assemblies to wear during the normal course of operation of the machine. As the wear occurs, minute particles become suspended in the fluid circulated within the axle assembly. As the particulate matter increases the wear is also accelerated and failure of one or more components in the axle assembly will frequently occur. The present invention provides an axle assembly with a filter and a cooler and flow control valve to remove the particulate matter and reduce the heat from the fluid circulated within the axle assembly.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: December 17, 1996
    Assignee: Caterpillar Inc.
    Inventors: Samuel L. Kershaw, James T. Passarelli, Frederick C. O'Neill, David R. Hinton