Abstract: In accordance with some embodiments, systems, methods, and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data are provided. In some embodiments, a system for estimating compensatory reserve is provided, the system comprising: a processor programmed to: receive a blood pressure waveform of a subject; generate a first sample of the blood pressure waveform with a first duration; provide the sample as input to a trained CNN that was trained using samples of the first duration from blood pressure waveforms recorded from subjects while decreasing the subject's central blood volume, each sample being associated with a compensatory reserve metric; receive, from the trained CNN, a first compensatory reserve metric based on the first sample; and cause information indicative of remaining compensatory reserve to be presented.

Abstract: Corneal improvement following a therapeutic procedure, such as Descemet membrane endothelial keratoplasty (“DMEK”), is predicted or otherwise monitored using Scheimpflug imaging and a machine learning model that has been trained to predict or otherwise monitor corneal improvement from Scheimpflug imaging parameters that are independent of corneal thickness. The machine learning model can include a predictive model trained using ensemble learning, or other suitable machine learning models such as neural networks.

Abstract: Systems and methods are provided for evaluating physiological signal quality. A physiological signal, based on a series measurements on a subject, may be received. A quality of the physiological signal received may be evaluated, and an analysis of the physiological signal may be based at least in part on the quality evaluation.

Abstract: In accordance with some embodiments, systems, methods, and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data are provided. In some embodiments, a system for estimating compensatory reserve is provided, the system comprising: a processor programmed to: receive a blood pressure waveform of a subject; generate a first sample of the blood pressure waveform with a first duration; provide the sample as input to a trained CNN that was trained using samples of the first duration from blood pressure waveforms recorded from subjects while decreasing the subject's central blood volume, each sample being associated with a compensatory reserve metric; receive, from the trained CNN, a first compensatory reserve metric based on the first sample; and cause information indicative of remaining compensatory reserve to be presented.

Abstract: Wound dressings having a delivery system are provided.

Abstract: Devices and methods can be used to treat of heart conditions, hypertension, and other medical disorders. For example, devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation are described herein. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

Abstract: Trimmable conformable wound dressings, kits containing the same and methods of using the same. The wound dressings may protect a treatment site from microbial contamination or other disturbances while a wound heals or to enable the application and maintenance of vacuum over the treatment site. The wound dressings may include first and second sections of support layer material on opposite sides of one or more intermediate sections of support layer material. The first and second sections of support layer material meet the intermediate sections of support layer material along peel tab junctions that provide peel tabs.

Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

Abstract: In accordance with some embodiments of the disclosed subject matter, mechanisms for distributed network monitoring are provided.

Abstract: Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.

Abstract: An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site and a second surface opposite the first surface; wherein at least one of the interconnected polymeric stand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; a plurality of openings between adjacent interconnected polymeric strands; an adhesive layer in contact with the second surface of the interconnected polymeric strands; and a filler in contact with the adhesive layer, the adhesive layer in between the network of interconnected polymeric strands and the filler; wherein the article is a negative pressure wound therapy article.

Abstract: Systems and methods are provided for evaluating physiological signal quality. A physiological signal, based on a series measurements on a subject, may be received. A quality of the physiological signal received may be evaluated, and an analysis of the physiological signal may be based at least in part on the quality evaluation.

Abstract: Medical articles comprising a conformable wound dressing and delivery system. The wound dressing generally comprises a backing having a first major surface and a second major surface, an adhesive on the second major surface of the backing, and an absorbent pad proximate the second major surface of the backing. The backing extends beyond the perimeter of the absorbent pad, typically beyond the entire perimeter of the pad. The perimeter of the wound dressing has a concave feature that exhibits a local minimum. An axis extends from the local minimum to the perimeter of the wound dressing opposite the local minimum. The carrier overlies at least a portion of the backing on each side of the axis but does not overlie the backing along the axis. The wound dressing is especially designed for use on round or irregular shaped body parts, such as an elbow or heel.

Abstract: A conformable wound dressing system that includes a backing and a dressing support layer. The backing has a first major surface, a second major surface opposite the first major surface, a perimeter that includes first and second lateral edges extending from a first end to a second end, and a longitudinal axis extending form the first end to the second end. An adhesive is on the first major surface and a dressing support layer is on the second major surface. The dressing support layer has a first section and second section where the first section is disconnected and spaced apart from the second section to define a gap extending from the first end of the backing to the second end of the backing.

Abstract: Systems and methods are provided for evaluating physiological signal quality. A physiological signal, based on a series measurements on a subject, may be received. A quality of the physiological signal received may be evaluated, and an analysis of the physiological signal may be based at least in part on the quality evaluation.

Abstract: A wound dressing system comprising a drape and a hydrogel sealant. The drape comprises a film and an adhesive on a first major surface of the film. The hydrogel comprises at least 30% by weight water, a crosslinked hydrophilic absorbent polymer; and a swelling agent. The hydrogel can create a seal between the drape and a surface (e.g., a patient's skin), making the disclosed systems suitable for negative pressure wound therapy (NPWT) applications.

Abstract: Trimmable conformable wound dressings, kits containing the same and methods of using the same. The wound dressings may protect a treatment site from microbial contamination or other disturbances while a wound heals or to enable the application and maintenance of vacuum over the treatment site. The wound dressings may include first and second sections of support layer material on opposite sides of one or more intermediate sections of support layer material. The first and second sections of support layer material meet the intermediate sections of support layer material along peel tab junctions that provide peel tabs.

Abstract: Trimmable conformable wound dressings, kits containing the same and methods of using the same. The wound dressings may protect a treatment site from microbial contamination or other disturbances while a wound heals or to enable the application and maintenance of vacuum over the treatment site. The wound dressings may include first and second sections of support layer material on opposite sides of one or more intermediate sections of support layer material. The first and second sections of support layer material meet the intermediate sections of support layer material along peel tab junctions that provide peel tabs.

Abstract: In accordance with some embodiments of the disclosed subject matter, mechanisms for efficient real-time embedded processing of physiological signals using S transforms are provided. In some embodiments, a system comprises: a sensor configured to monitor at least one condition of the subject and generate physiological feedback data; a processor configured to receive the physiological feedback data from the sensor and programmed to: implement a ECG Leads filter bank with a predetermined number of coefficients and taps selected to perform a Stockwell transform on the physiological feedback data and provide a frequency domain data of the physiological feedback data; analyze the frequency domain data using a physiological monitoring criteria; generate a report about the physiological condition of the subject based on the analysis of the frequency domain data using the physiological monitoring criteria; a display configured to display the report about the physiological condition of the subject.