Abstract: Devices and methods can be used to treat of heart conditions, hypertension, and other medical disorders. For example, devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation are described herein. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

Abstract: In accordance with some embodiments of the disclosed subject matter, mechanisms for distributed network monitoring are provided.

Abstract: Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.

Abstract: Systems and methods are provided for evaluating physiological signal quality. A physiological signal, based on a series measurements on a subject, may be received. A quality of the physiological signal received may be evaluated, and an analysis of the physiological signal may be based at least in part on the quality evaluation.

Abstract: Systems and methods are provided for evaluating physiological signal quality. A physiological signal, based on a series measurements on a subject, may be received. A quality of the physiological signal received may be evaluated, and an analysis of the physiological signal may be based at least in part on the quality evaluation.

Abstract: In accordance with some embodiments of the disclosed subject matter, mechanisms for efficient real-time embedded processing of physiological signals using S transforms are provided. In some embodiments, a system comprises: a sensor configured to monitor at least one condition of the subject and generate physiological feedback data; a processor configured to receive the physiological feedback data from the sensor and programmed to: implement a ECG Leads filter bank with a predetermined number of coefficients and taps selected to perform a Stockwell transform on the physiological feedback data and provide a frequency domain data of the physiological feedback data; analyze the frequency domain data using a physiological monitoring criteria; generate a report about the physiological condition of the subject based on the analysis of the frequency domain data using the physiological monitoring criteria; a display configured to display the report about the physiological condition of the subject.

Abstract: In accordance with some embodiments, systems, methods, and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data are provided. In some embodiments, a system for estimating compensatory reserve is provided, the system comprising: a processor programmed to: receive a blood pressure waveform of a subject; generate a first sample of the blood pressure waveform with a first duration; provide the sample as input to a trained CNN that was trained using samples of the first duration from blood pressure waveforms recorded from subjects while decreasing the subject's central blood volume, each sample being associated with a compensatory reserve metric; receive, from the trained CNN, a first compensatory reserve metric based on the first sample; and cause information indicative of remaining compensatory reserve to be presented.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for applying ablation therapy to a tissue region. The apparatuses, systems, and methods may include a balloon structure and one or more electrodes arranged on or within the balloon structure and configured to deliver energy to the tissue region.

Abstract: Systems and methods are provided for evaluating physiological signal quality. A physiological signal, based on a series measurements on a subject, may be received. A quality of the physiological signal received may be evaluated, and an analysis of the physiological signal may be based at least in part on the quality evaluation.

Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

Abstract: Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for applying ablation therapy to a tissue region. The apparatuses, systems, and methods may include a balloon structure and one or more electrodes arranged on or within the balloon structure and configured to deliver energy to the tissue region.

Abstract: Devices and methods can be used to treat heart conditions. Some such devices include endocardial occlusion and ablation devices. For example, such devices can be used for closing and ablating the left atrial appendage to treat atrial fibrillation and to reduce the potential for embolic stroke. In addition, this document provides devices and methods for closing and ablating other body viscera, conduits, valves, and the like.

Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.

Abstract: An apparatus and method of use are disclosed for treating, preventing and terminating arrhythmias. In particular, the apparatus is implantable within or on various tissues and structures and is used to prevent or block conduction of aberrant impulses. A variety of methods of the present invention may be used to attack arrhythmias by short-circuiting impulses, inducing fibrosis, ablating tissue or inducing inflammation. In addition, the device and methods may also be used to treat aneurysms. The device may also be used to treat hypertension, and to function as a blood pressure regulator.

Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.

Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.