Patents by Inventor David R. Knop

David R. Knop has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT AAV PRODUCTION IN MAMMALIAN CELLS
    Publication number: 20210340503
    Abstract: The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.
    Type: Application
    Filed: March 15, 2021
    Publication date: November 4, 2021
    Inventors: Kyu-Kye Hwang, David R. Knop, James Conway, Barry J. Byrne
  • FORMULATION OPTIMIZATION FOR VIRAL PARTICLES
    Publication number: 20210123028
    Abstract: The present disclosure provides formulations for maintaining viral particles in a stable form. In certain embodiments, the formulation comprises at least one basic amino acid and a buffer solution, wherein the viral particle is present at a concentration of about 1×1011 to about 5×1013 DNase resistant virus particles per mL.
    Type: Application
    Filed: June 5, 2020
    Publication date: April 29, 2021
    Inventors: David R. Knop, Chantelle Gaskin, Yuyu Long
  • RECOMBINANT AAV PRODUCTION IN MAMMALIAN CELLS
    Publication number: 20190017033
    Abstract: The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.
    Type: Application
    Filed: April 10, 2018
    Publication date: January 17, 2019
    Inventors: Kyu-Kye Hwang, David R. Knop, James Conway, Barry J. Byrne
  • RECOMBINANT VIRUS PRODUCTION USING MAMMALIAN CELLS IN SUSPENSION
    Publication number: 20180312872
    Abstract: The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy.
    Type: Application
    Filed: September 7, 2017
    Publication date: November 1, 2018
    Inventors: David R. Knop, Darby Thomas, Gabor Veres
  • Recombinant virus production using mammalian cells in suspension
    Patent number: 9783826
    Abstract: The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: October 10, 2017
    Assignee: Applied Genetic Technologies Corporation
    Inventors: David R. Knop, Darby Thomas, Gabor Veres
  • Biocatalytic synthesis of shikimic acid
    Patent number: 6613552
    Abstract: A bioengineered synthesis scheme for the production of shikimic acid from a carbon source is provided. Methods of producing shikimic acid from a carbon source based on the synthesis scheme are also provided.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: September 2, 2003
    Assignee: Board of Trustees operating Michigan State University
    Inventors: John W. Frost, Karen M. Frost, David R. Knop
  • Biocatalytic synthesis of shikimic acid
    Patent number: 6472169
    Abstract: A bioengineered synthesis scheme for the production of shikimic acid from a carbon source is provided. Methods of producing shikimic acid from a carbon source based on the synthesis scheme are also provided.
    Type: Grant
    Filed: September 30, 2000
    Date of Patent: October 29, 2002
    Assignee: Board of Trustees operating Michigan State University
    Inventors: John W. Frost, Karen M. Frost, David R. Knop