Abstract: Various methods and devices are provided for allowing multiple surgical instruments to be inserted into sealing elements of a single surgical access device. The sealing elements can be movable along predefined pathways within the device to allow surgical instruments inserted through the sealing elements to be moved laterally, rotationally, angularly, and vertically relative to a central longitudinal axis of the device for ease of manipulation within a patient's body while maintaining insufflation.

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

Abstract: A position fix identifying a geographic location of a receiver is received. The position fix was generated using signals received at the receiver from respective high-altitude signal sources (such as satellites). Imagery of a geographic area that includes the geographic location is also received. The imagery is automatically processed to determine whether one or more of the high-altitude signal sources were occluded from the geographic location when the position fix was generated. In response to determining that one or more of the high-altitude signal sources were occluded from the geographic location when the position fix was generated, the position fix is identified as being potentially erroneous.

Abstract: A position fix identifying a geographic location of a receiver is received. The position fix was generated using signals received at the receiver from respective high-altitude signal sources (such as satellites). Imagery of a geographic area that includes the geographic location is also received. The imagery is automatically processed to determine whether one or more of the high-altitude signal sources were occluded from the geographic location when the position fix was generated. In response to determining that one or more of the high-altitude signal sources were occluded from the geographic location when the position fix was generated, the position fix is identified as being potentially erroneous.

Abstract: An apparatus and method are disclosed for performing loop closing on one or more paths to be optimized. The paths may include poses associated with imagery obtained by a vehicle. The apparatus may identify candidate intersections from the paths based on their proximity, and may further determine relative poses from the poses of the paths using structure-from-motion techniques. The apparatus may then apply a partitioning schema to the paths to be optimized to obtain individual partition cells. The partition cells may then be sent to one or more client devices for optimizing the paths included in the partition cells. When the apparatus receives a set of optimized paths from the client devices, the apparatus may re-partition the paths to be optimized to ensure that non-optimized portions of paths are optimized.

Abstract: A coolable airfoil having internal cooling passages 82, 84, 74 is disclosed. Various construction details are developed to increase cooling in critical locations of the airfoil. In one embodiment, a pair of side-by-side spanwisely extending passages 82, 84 flow cooling air to the tip passage 74 which extends rearwardly in a flag-like manner.

Abstract: An airfoil core has a frame formed of passage forming elements supporting a pair of spanwisely extending passage forming elements within the frame. The pair of passage forming elements has at least one plurality of hole forming elements extending chordwisely therefrom and supported in part by at least one of the pair of passage forming elements to increase the durability of the core. In one embodiment, the core includes a trailing edge region framed by spanwisely and chordwisely extending elements.

Abstract: A valve assembly embodies a valve element, an expansible and contractible chamber space having porting via which it is expanded and contracted, and a connecting rod that transmits the expansion and contraction of the chamber space to the valve element, in a signal plastic part.

Abstract: The shaft coupling a reciprocating piston of a fluid motor to a slide valve shiftable longitudinally along a screw compressor housing and varying the amount of compressor suction gas returned to the suction port for varying compressor capacity constitutes an outer hollow tube having a smaller diameter indicator shaft mounted axially therein. The shaft carriers a helical V-groove on its exterior surface and a spring biased pin projecting radially inwardly from the outer tube rides in the helical groove such that, as the slide valve reciprocates, driven by the fluid motor piston, the indicator shaft is rotatably driven about its axis. Multiple cams fixed to the indicator shaft and rotatable therewith actuate juxtapositioned microswitches to indicate full load position, full unload position, and two intermediate load positions for the slide valve. The indicator shaft is directly axially connected to a potentiometer to provide an electrical analog output signal.

Abstract: Disclosed is a solid state signal controller designed to be inserted in a radio frequency transmission line or path between a source and a signal utilization device to allow the control by external means of signal amplitude ratio and polarity, with a minimum of distortion of the signal. This invention has a dynamic range of more than 100 db and is capable of greater power handling capacity than the prior art signal controllers. It employs a plurality of semiconductor diodes, commonly known as PIN diodes, each cooperating with an energy coupler and having their respective impedances controlled to effect a reflection of energy with either positive or negative polarity toward an output terminal.In one embodiment employing a single channel, a pair of control elements are employed. In the second embodiment, four impedance elements are employed to produce a pair of quadrature signals, each independently controllable in amplitude and polarity.