Patents by Inventor David R. Sell

David R. Sell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for assessing the biological age of a tissue
    Patent number: 5480807
    Abstract: The present invention is directed to use of an imidazo [4,5b] pyridinium molecule composed of a lysine and an arginine residue crosslinked with a pentose sugar for assessing the biological age of a tissue.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: January 2, 1996
    Assignee: Case Western Reserve University
    Inventors: Vincent M. Monnier, David R. Sell
  • Imidazopyridinium compound and processes for isolating, identifying, and chemically synthesizing same
    Patent number: 5374712
    Abstract: The present invention is directed to a novel imidazo [4,5b] pyridinium molecule composed of a lysine and an arginine residue crosslinked with a pentose sugar. The novel imidazo [4,5b] pyridinium compound, referred to as "pentosidine", was isolated from proteineous tissue undergoing advanced glycosylation and is believed to be one of the principal products involved in the nonenzymatic browning and/or aging of proteins. Assaying for the pentosidine molecule makes it possible to assess the degree of aging of proteins in vivo as mediated by pentose induced crosslinking and modulated by disease such as diabetes and nephropathy. In addition, the pentosidine molecule may be utilized through the production of monoclonal antibodies thereto and/or the preparation of test kits, etc. for diagnostic, as well as therapeutic purposes (i.e. development of agents which inhibit the non-enzymatic browning reaction, etc.).
    Type: Grant
    Filed: June 16, 1992
    Date of Patent: December 20, 1994
    Assignee: Case Western Reserve University
    Inventors: Vincent M. Monnier, David R. Sell
  • Imidazopyridinium compound and processes for isolating, identifying, and chemically synthesizing same
    Patent number: 5214138
    Abstract: The present invention is directed to a novel imidazo [4,5b] pyridinium molecule composed of a lysine and an arginine residue crosslinked with a pentose sugar. The novel imidazo [4,5b] pyridinium compound, referred to as "pentosidine", was isolated from proteineous tissue undergoing advanced glycosylation and is believed to be one of the principal products involved in the non-enzymatic browning and/or aging of proteins. Assaying for the pentosidine molecule makes it possible to assess the degree of aging of proteins in vivo as mediated by pentose induced crosslinking and modulated by disease such as diabetes and nephropathy In addition, the pentosidine molecule may be utilized through the production of monoclonal antibodies thereto and/or the preparation of test kits, etc. for diagnostic, as well as therapeutic purposes (i.e. development of agents which inhibit the non-enzymatic browning reaction, etc.).
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: May 25, 1993
    Assignee: Case Western Reserve University
    Inventors: Vincent M. Monnier, David R. Sell