Patents by Inventor David R. Thatcher

David R. Thatcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of plasmid DNA production and purification
    Patent number: 6503738
    Abstract: A scalable method for the production of highly purified plasmid DNA in Escherichia coli is described, which method includes growing plasmid-containing cells to a high biomass in exponential growth and lysing the cells by raising the pH of the culture to a carefully controlled pH value in which chromosomal DNA is denatured but plasmid DNA is reversibly renatured. The method has been developed for the production of pharmaceutical grade DNA for use in in vivo and ex vivo gene therapy.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: January 7, 2003
    Assignee: Cobra Therapeutics Limited
    Inventors: David R. Thatcher, Anthony Hitchcock, Julian A. J. Hanak, Diane L. Varley
  • Optimization of gene delivery and gene delivery system
    Patent number: 6218112
    Abstract: Methods of screening for peptides useful in a gene delivery system to provide optimal transfection of cells based on kinetic parameters of the peptide-nucleic acid bimolecular interaction are described.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: April 17, 2001
    Assignee: Cobra Therapeutics Limited
    Inventors: David R. Thatcher, Paula E. Wilks
  • Method of plasmid DNA production and purification
    Patent number: 5981735
    Abstract: A scalable method for the production of highly purified plasmid DNA in Escherichia coli is described, which method includes growing plasmid-containing cells to a high biomass in exponential growth and lysing the cells by raising the pH of the culture to a carefully controlled pH value in which chromosomal DNA is denatured but plasmid DNA is reversibly renatured. The method has been developed for the production of pharmaceutical grade DNA for use in in vivo and ex vivo gene therapy.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: November 9, 1999
    Assignee: Cobra Therapeutics Limited
    Inventors: David R. Thatcher, Anthony Hitchcock, Julian A.J. Hanak, Diane L. Varley
  • Compositions for insulin-receptor mediated nucleic acid delivery
    Patent number: 5830852
    Abstract: The invention is based on the discovery of a pharmaceutical preparation for use in gene therapy which includes a therapeutic nucleic acid associated with Insulin-NHCO--CH.sub.2 --O--N.dbd.CH--C-Lys.sub.18 -Cys(S-Pyridyl)-OH in combination with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: November 3, 1998
    Assignee: Cobra Therapeutics, Ltd.
    Inventors: David R. Thatcher, Robin E. Offord, Keith Rose, Hubert F. Gaertner
  • Stabilized formulations of gamma interferons
    Patent number: 4895716
    Abstract: This invention relates to compositions and methods useful for the stabilization of interferons. More particularly, this invention relates to the formulation of gamma interferons with lactobionic acid in an acetate/glycine buffer.
    Type: Grant
    Filed: June 9, 1987
    Date of Patent: January 23, 1990
    Assignee: Biogen, Inc.
    Inventors: Joel D. Goldstein, David R. Thatcher