Patents by Inventor David R. Weyna

David R. Weyna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms
    Patent number: 10526358
    Abstract: The invention relates to the preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid. The invention also relates to the use of the novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid in pharmaceutical compositions in drug delivery systems for humans. The invention further relates to the use of the novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid or the pharmaceutical compositions thereof to treat and/or prevent a disease state associated with osteoporosis, tumor induced hypercalcemia (TIH), cancer-induced bone metastasis, Paget's disease or for adjuvant or neoadjuvant therapies.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: January 7, 2020
    Assignee: THAR PHARMA, LLC
    Inventors: Mazen Hanna, Ning Shan, David R. Weyna, Miranda L. Cheney
  • Crystalline forms
    Patent number: 10519176
    Abstract: Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: December 31, 2019
    Assignee: THAR PHARMA, LLC
    Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Paul K. Isbester, Xufeng Sun
  • Crystallization method and bioavailability
    Patent number: 10323052
    Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: June 18, 2019
    Assignee: GRUNENTHAL GMBH
    Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Raymond K. Houck
  • NOVEL CRYSTALLINE FORMS
    Publication number: 20190144474
    Abstract: Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Application
    Filed: November 12, 2018
    Publication date: May 16, 2019
    Applicant: GRUNENTHAL GMBH
    Inventors: Mazen HANNA, Ning SHAN, David R. WEYNA, Miranda L. CHENEY
  • NOVEL CRYSTALLINE FORMS
    Publication number: 20190002483
    Abstract: Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Application
    Filed: November 2, 2017
    Publication date: January 3, 2019
    Applicant: GRUNENTHAL GMBH
    Inventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA, Paul K. ISBESTER, Xufeng SUN
  • CRYSTALLIZATION METHOD AND BIOAVAILABILITY
    Publication number: 20180333425
    Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Application
    Filed: November 21, 2017
    Publication date: November 22, 2018
    Applicant: GRUNENTHAL GMBH
    Inventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA, Raymond K. HOUCK
  • Crystallization method and bioavailability
    Patent number: 10093691
    Abstract: Preparation and in vitro and in vivo characterization of novel forms of active pharmaceutical ingredients, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: October 9, 2018
    Assignee: GRUNENTHAL GMBH
    Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Raymond Houck
  • Oral forms of a phosphonic acid derivative
    Patent number: 9682091
    Abstract: Novel solution complexes of zoledronic acid are described which give rise to improved properties of zoledronic acid. The invention includes aqueous solution and molecular complexes of zoledronic acid with and optical isomers of asparagine, histidine, arginine and proline as well as pharmaceutical complexes containing them and methods of treatment using them.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: June 20, 2017
    Assignee: GRUNENTHAL GMBH
    Inventors: Mazen Hanna, Ning Shan, Miranda Cheney, David R. Weyna
  • CRYSTALLIZATION METHOD AND BIOAVAILABILITY
    Publication number: 20170022226
    Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Application
    Filed: April 19, 2016
    Publication date: January 26, 2017
    Inventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA, Raymond K. HOUCK
  • CRYSTALLIZATION METHOD AND BIOAVAILABILITY
    Publication number: 20170022227
    Abstract: Preparation and in vitro and in vivo characterization of novel forms of active pharmaceutical ingredients, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Application
    Filed: October 7, 2016
    Publication date: January 26, 2017
    Applicant: THAR PHARMACEUTICALS, INC.
    Inventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA, Raymond HOUCK
  • NOVEL CRYSTALLINE FORMS
    Publication number: 20170022225
    Abstract: Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Application
    Filed: April 15, 2016
    Publication date: January 26, 2017
    Inventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA, Paul K. ISBESTER, Xufeng SUN
  • Crystalline forms
    Patent number: 9340565
    Abstract: Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: May 17, 2016
    Assignee: THAR PHARMACEUTICALS, INC.
    Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Paul K. Isbester, Xufeng Sun
  • Crystallization method and bioavailability
    Patent number: 9334296
    Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 10, 2016
    Assignee: THAR PHARMACEUTICALS, INC.
    Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Raymond K. Houck
  • CRYSTALLIZATION METHOD AND BIOAVAILABILITY
    Publication number: 20160016982
    Abstract: Preparation and in vitro and in vivo characterization of novel forms of active pharmaceutical ingredients, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Application
    Filed: June 4, 2015
    Publication date: January 21, 2016
    Applicant: THAR PHARMACEUTICALS, INC.
    Inventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA, Raymond HOUCK
  • NOVEL ORAL FORMS OF A PHOSPHONIC ACID DERIVATIVE
    Publication number: 20150306116
    Abstract: Novel solution complexes of zoledronic acid are described which give rise to improved properties of zoledronic acid. The invention includes aqueous solution and molecular complexes of zoledronic acid with and optical isomers of asparagine, histidine, arginine and proline as well as pharmaceutical complexes containing them and methods of treatment using them.
    Type: Application
    Filed: March 13, 2015
    Publication date: October 29, 2015
    Applicant: THAR PHARMACEUTICALS, INC.
    Inventors: Mazen HANNA, Ning SHAN, Miranda CHENEY, David R. WEYNA
  • Crystallization method and bioavailability
    Patent number: 9169279
    Abstract: Preparation and in vitro and in vivo characterization of novel forms of active pharmaceutical ingredients, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: October 27, 2015
    Assignee: THAR PHARMACEUTICALS, INC.
    Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Raymond Houck
  • Crystalline molecular comlpexes of tadalafil
    Patent number: 9040535
    Abstract: Crystalline molecular complexes of tadalafil are disclosed. The crystalline molecular complexes include those of tadalafil and oxalic acid, tadalafil and 4-hydroxybenzoic acid, tadalafil and 3-phenylpropanoic acid, tadalafil and malonic acid, tadalafil and methylparaben, and tadalafil and propylparaben. Pharmaceutical compositions containing the crystalline molecular complexes are also disclosed.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: May 26, 2015
    Assignee: THAR PHARMACEUTICALS, INC.
    Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna
  • Crystallization method and bioavailability
    Patent number: 8933057
    Abstract: Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: January 13, 2015
    Assignee: Thar Pharmaceuticals, Inc.
    Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Raymond K. Houck
  • CRYSTALIZATION OF PHARMACEUTICAL COMPOUNDS
    Publication number: 20140100233
    Abstract: Novel crystalline forms of tadalafil suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 10, 2014
    Applicant: THAR PHARMACEUTICALS, INC.
    Inventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA
  • NOVEL CRYSTALLINE FORMS
    Publication number: 20130316982
    Abstract: Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
    Type: Application
    Filed: November 23, 2011
    Publication date: November 28, 2013
    Applicant: THAR PHARMACEUTICALS, INC.
    Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Paul K. Isbester, Xufeng Sun