Patents by Inventor David Raab

David Raab has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140336637
    Abstract: A medical system configured for nerve modulation can include an elongate shaft, having a distal end region and a proximal end region is disclosed. Adjacent the distal end region an ablation electrode can be disposed. The system can further include a first optical fiber, having a proximal end and a distal end, extending along an outer surface of the elongate shaft, and in turn a number of (fiber Bragg Grating) FBG sensors therein. The FBG sensors can be positioned adjacent to the ablation electrode. An optical read out mechanism can be optically coupled to the optical fiber to transmit light into the optical fiber and detect light reflected from the FBG sensor. Here, the detected light, reflected from FBG temperature sensors, encodes local temperatures at each of the FBG temperature sensors.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: SUMIT AGRAWAL, PRAMODSINGH HIRASINGH THAKUR, DAVID RAAB, STEVE HONGXI ZHANG, TRAVIS J. SCHAUER
  • Patent number: 8859275
    Abstract: The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: October 14, 2014
    Assignee: GeneArt AG
    Inventors: Frank Notka, Marcus Graf, Doris Leikam, Ralf Wagner, David Raab
  • Publication number: 20140228558
    Abstract: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps. The invention additionally relates to a device for carrying out this method.
    Type: Application
    Filed: September 23, 2013
    Publication date: August 14, 2014
    Applicant: GENEART AG
    Inventors: David RAAB, Marcus Graf, Frank Notka, Ralf Wagner
  • Publication number: 20130123483
    Abstract: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps. The invention additionally relates to a device for carrying out this method.
    Type: Application
    Filed: June 15, 2012
    Publication date: May 16, 2013
    Applicant: GENEART AG
    Inventors: DAVID RAAB, MARCUS GRAF, FRANK NOTKA, RALF WAGNER
  • Patent number: 8224578
    Abstract: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps. The invention additionally relates to a device for carrying out this method.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: July 17, 2012
    Assignee: Geneart AG
    Inventors: David Raab, Marcus Graf, Frank Notka, Ralf Wagner
  • Publication number: 20120022966
    Abstract: The present invention relates to a method and a system for providing a customer biopolymer to a customer. The sequence of a customer biopolymer is transferred to a production control system of a biopolymer service provider, synthesized on a production machine of the service provider and delivered to the customer, wherein no human action is necessary to initiate or control the synthesis process.
    Type: Application
    Filed: July 29, 2011
    Publication date: January 26, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: David RAAB, Thomas Schoedl
  • Publication number: 20090324546
    Abstract: The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors.
    Type: Application
    Filed: August 3, 2005
    Publication date: December 31, 2009
    Inventors: Frank D. Notka, Marcus Graf, Doris Leikam, Ralf Wagner, David Raab
  • Publication number: 20090094042
    Abstract: The present invention relates to a method and a system for providing a customer biopolymer to a customer. The sequence of a customer biopolymer is transferred to a production control system of a biopolymer service provider, synthesized on a production machine of the service provider and delivered to the customer, wherein no human action is necessary to initiate or control the synthesis process.
    Type: Application
    Filed: October 9, 2007
    Publication date: April 9, 2009
    Applicant: Mr. Gene GmbH
    Inventors: David RAAB, Thomas Schoedl
  • Publication number: 20070141557
    Abstract: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps. The invention additionally relates to a device for carrying out this method.
    Type: Application
    Filed: December 23, 2003
    Publication date: June 21, 2007
    Inventors: David Raab, Marcus Graf, Frank Notka, Ralf Wagner