Patents by Inventor David Rabuka

David Rabuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HYDRAZINYL-PYRROLO COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE
    Publication number: 20170049907
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: September 26, 2016
    Publication date: February 23, 2017
    Inventors: David Rabuka, Aaron Edward Albers, Romas Alvydas Kudirka, Albert W. Garofalo
  • Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
    Patent number: 9540438
    Abstract: The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: January 10, 2017
    Assignee: Redwood Bioscience, Inc.
    Inventors: Robyn M. Barfield, Mark Alan Breidenbach, Gregory W. deHart, David Rabuka
  • Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
    Patent number: 9493413
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: November 15, 2016
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Aaron Edward Albers, Romas Alvydas Kudirka, Albert W. Garofalo
  • NOVEL ANTIBACTERIAL AGENTS
    Publication number: 20160280718
    Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
    Type: Application
    Filed: November 4, 2015
    Publication date: September 29, 2016
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, Steve Sucheck, Kenneth Marby, Youe-Kong Shue, Yoshitaka Ichikawa, Chan-Kou Hwang, David Rabuka, Sulan Yao
  • Hydrazinyl-Indole Compounds and Methods for Producing a Conjugate
    Publication number: 20160250342
    Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: March 1, 2016
    Publication date: September 1, 2016
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, Robyn M. Barfield, David Rabuka
  • Activated Formylglycine-Generating Enzymes and Methods of Producing and Using the Same
    Publication number: 20160230205
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Application
    Filed: December 18, 2015
    Publication date: August 11, 2016
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Antibody Specific for CD22 and Methods of Use Thereof
    Publication number: 20160229911
    Abstract: The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.
    Type: Application
    Filed: October 8, 2015
    Publication date: August 11, 2016
    Inventors: David Rabuka, Robert George Edward Holgate, Francis Joseph Carr
  • Aldehyde-Tagged Protein-Based Drug Carriers and Methods of Use
    Publication number: 20160160206
    Abstract: The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use.
    Type: Application
    Filed: December 4, 2015
    Publication date: June 9, 2016
    Inventors: David Rabuka, Mark Alan Breidenbach
  • Hydrazinyl-indole compounds and methods for producing a conjugate
    Patent number: 9310374
    Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: April 12, 2016
    Assignee: REDWOOD BIOSCIENCE, INC.
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, Robyn M. Barfield, David Rabuka
  • Compounds and Methods for Producing a Conjugate
    Publication number: 20160038602
    Abstract: The present disclosure provides conjugate structures and compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: May 5, 2015
    Publication date: February 11, 2016
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, David Rabuka
  • Aldehyde-tagged protein-based drug carriers and methods of use
    Patent number: 9238878
    Abstract: The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: January 19, 2016
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Mark Alan Breidenbach
  • Anti-Her2 Antibody-Maytansine Conjugates and Methods of Use Thereof
    Publication number: 20150352225
    Abstract: The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: May 27, 2015
    Publication date: December 10, 2015
    Inventors: David Rabuka, Aaron Edward Albers, Robyn M. Barfield, Gregory W. deHart, Penelope M. Drake, Romas Alvydas Kudirka, Albert W. Garofalo, Jesse M. McFarland
  • Antibacterial agents
    Patent number: 9200026
    Abstract: Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: December 1, 2015
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, Steve Sucheck, Kenneth Marby, Youe-Kong Shue, Yoshitaka Ichikawa, Chan-Kou Hwang, David Rabuka, Sulan Yao
  • Antibody specific for CD22 and methods of use thereof
    Patent number: 9181343
    Abstract: The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: November 10, 2015
    Assignee: Redwood Bioscience Inc.
    Inventors: David Rabuka, Robert George Edward Holgate, Francis Joseph Carr
  • HYDRAZINYL-PYRROLO COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE
    Publication number: 20150157736
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: November 26, 2014
    Publication date: June 11, 2015
    Inventors: David Rabuka, Aaron Edward Albers, Romas Alvydas Kudirka, Albert W. Garofalo
  • Antibody Specific for CD22 and Methods of Use Thereof
    Publication number: 20140161870
    Abstract: The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.
    Type: Application
    Filed: July 15, 2013
    Publication date: June 12, 2014
    Inventors: David Rabuka, Robert George Edward Holgate, Francis Joseph Carr
  • HYDRAZINYL-INDOLE COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE
    Publication number: 20140141025
    Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: March 11, 2013
    Publication date: May 22, 2014
    Applicant: REDWOOD BIOSCIENCE, INC.
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, Robyn M. Barfield, David Rabuka
  • Aldehyde-Tagged Immunoglobulin Polypeptides and Methods of Use Thereof
    Publication number: 20120183566
    Abstract: The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
    Type: Application
    Filed: January 13, 2012
    Publication date: July 19, 2012
    Inventors: Robyn M. Barfield, Mark Alan Breidenbach, Gregory W. deHart, David Rabuka
  • Aldehyde-Tagged Protein-Based Drug Carriers and Methods of Use
    Publication number: 20100210543
    Abstract: The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use.
    Type: Application
    Filed: February 16, 2010
    Publication date: August 19, 2010
    Inventors: David Rabuka, Mark Alan Breidenbach
  • Antibacterial agents
    Patent number: 7601695
    Abstract: Described herein are novel macrolides, the preparation of novel macrolides, to the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: October 13, 2009
    Assignee: Optimer Pharmaceuticals, Inc.
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, David Rabuka, Sulan Yao, Steve Sucheck, Kenneth Marby, Youe-kong Shue, Yoshi Ichikawa, Chan-Kou Hwang