Patents by Inventor David Ralin
David Ralin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8557609Abstract: A method employing gel electrophoresis and optical imaging techniques to measure the amount of biomaterial that attaches to specified locations on a detector slide such as a bioarray or biochip.Type: GrantFiled: October 18, 2010Date of Patent: October 15, 2013Assignee: Maven Biotechnologies, LLCInventors: Shane Dultz, David Ralin, William Rassman
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Patent number: 8355133Abstract: In one embodiment, an apparatus is provided for testing for the presence of analytes in a sample. The apparatus comprises a source of light directed at the bottom surface of a substrate to achieve total internal reflection and to generate an evanescent field. An array of capture elements is immobilized on the top surface of the substrate. The bottom surface of the substrate is configured as a sawtooth (in cross section), the “teeth” aligned with the rows or the columns in the array. The outer faces of the sawtooth “prisms” are non-parallel to the substrate top surface, and specific requirements are imposed on the prism light-entrance face, and the substrate thickness and refractive index.Type: GrantFiled: December 30, 2009Date of Patent: January 15, 2013Assignee: Maven Technologies, LLCInventors: Shane C. Dultz, David Ralin
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Patent number: 8039270Abstract: Ellipsometry systems for imaging binding events between analytes in a sample and an array of ligands in an evanescent field generated by a beam of light reflected from the plane of the ligands is adapted to a multiwell plate structure in common use. In one example, a film of prism arrays is affixed to the underside of the plate with each prism array located in registry with a well and ligand arrays being immobilized on the (planar) bottom surface of the wells. The prism array may be formed in a film and juxtaposed with the bottom surface of the plate or a prism array can be made integral with the plate bottom of a multiwell plate.Type: GrantFiled: May 22, 2008Date of Patent: October 18, 2011Assignee: Maven Technologies, LLCInventors: Shane C Dultz, David Ralin
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Publication number: 20110157693Abstract: In one embodiment, an apparatus is provided for testing for the presence of analytes in a sample. The apparatus comprises a source of light directed at the bottom surface of a substrate to achieve total internal reflection and to generate an evanescent field. An array of capture elements is immobilized on the top surface of the substrate. The bottom surface of the substrate is configured as a sawtooth (in cross section), the “teeth” aligned with the rows or the columns in the array. The outer faces of the sawtooth “prisms” are non-parallel to the substrate top surface, and specific requirements are imposed on the prism light-entrance face, and the substrate thickness and refractive index.Type: ApplicationFiled: December 30, 2009Publication date: June 30, 2011Applicant: Maven Technologies, LLCInventors: Shane C. Dultz, David Ralin
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Patent number: 7867783Abstract: An apparatus and method for real time, label-free imaging and quantitation of binding events at an array of positions are provided. Total internal reflection from a planar side wall of a well of a multiwell plate is used to create an evanescent field in the plane of a pattern of ligands immobilized on the wall. Embodiments include imaging and multiple analyte detection and quantitation of a single wall of a single well as well as the simultaneous imaging and multiple analyte detection and quantitation of a number of wells.Type: GrantFiled: February 22, 2007Date of Patent: January 11, 2011Assignee: Maven Technologies, LLCInventors: Shane C. Dultz, Jeffrey C. Travis, David Ralin
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Patent number: 7838285Abstract: Apparatus and method employing gel electrophoresis and optical imaging techniques to measure the amount of biomaterial that attaches to specified locations on a detector slide and to determine the molecular weight of the molecules at those locations.Type: GrantFiled: April 24, 2006Date of Patent: November 23, 2010Assignee: Maven Biotechnologies LLCInventors: Shane Dultz, David Ralin, William Rassman
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Publication number: 20090290157Abstract: Ellipsometry systems for imaging binding events between analytes in a sample and an array of ligands in an evanescent field generated by a beam of light reflected from the plane of the ligands is adapted to a multiwell plate structure in common use. In one example, a film of prism arrays is affixed to the underside of the plate with each prism array located in registry with a well and ligand arrays being immobilized on the (planar) bottom surface of the wells. The prism array may be formed in a film and juxtaposed with the bottom surface of the plate or a prism array can be made integral with the plate bottom of a multiwell plate.Type: ApplicationFiled: May 22, 2008Publication date: November 26, 2009Applicant: Maven Technologies, LLCInventors: Shane C. Dultz, David Ralin
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Patent number: 7518724Abstract: Image data is acquired, processed, and/or displayed in accordance with an embodiment of the present disclosure to display, monitor, and/or demonstrate the progress of an experiment substantially in real-time and with high sensitivity. In one embodiment, at least one time-resolved value of spatially distributed polarization change data is provided and displayed. Advantageously, real-time processing and display of data is provided such that discussion and collaboration about the experiment may occur, time-resolved data is not lost, and resources are not wasted.Type: GrantFiled: December 29, 2005Date of Patent: April 14, 2009Assignee: Maven TechnologiesInventors: William R. Rassman, David Ralin, Jason D. Berger, Robert A. Lieberman, Lothar U. Kempen
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Publication number: 20090041633Abstract: An apparatus and method for real time, label-free imaging and quantitation of binding events at an array of positions are provided. Total internal reflection from a planar side wall of a well of a multiwell plate is used to create an evanescent field in the plane of a pattern of ligands immobilized on the wall. Embodiments include imaging and multiple analyte detection and quantitation of a single wall of a single well as well as the simultaneous imaging and multiple analyte detection and quantitation of a number of wells.Type: ApplicationFiled: May 14, 2007Publication date: February 12, 2009Inventors: Shane C. Dultz, Jeffrey Travis, David Ralin
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Publication number: 20080216334Abstract: Apparatus for determining the status of hair bulk in an area of a scalp is operative to provide a metric over a sufficiently large area to permit revisiting with only negligible misalignment error. Accurate re-measurement of hair status in accurately identified areas produces a reliable metric for determining degree of hair loss and or the effectiveness of treatment.Type: ApplicationFiled: March 6, 2007Publication date: September 11, 2008Inventors: Jae P. Pak, William R. Rassman, Shane C. Dultz, David Ralin
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Publication number: 20080207463Abstract: An apparatus and method for real time, label-free imaging and quantitation of binding events at an array of positions are provided. Total internal reflection from a planar side wall of a well of a multiwell plate is used to create an evanescent field in the plane of a pattern of ligands immobilized on the wall. Embodiments include imaging and multiple analyte detection and quantitation of a single wall of a single well as well as the simultaneous imaging and multiple analyte detection and quantitation of a number of wells.Type: ApplicationFiled: February 22, 2007Publication date: August 28, 2008Inventors: Shane C. Dultz, Jeffrey C. Travis, David Ralin
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Publication number: 20080204750Abstract: Image data is acquired, processed, and/or displayed in accordance with an embodiment of the present disclosure to display, monitor, and/or demonstrate the progress of an experiment substantially in real-time and with high sensitivity. In one embodiment, at least one time-resolved value of spatially distributed polarization change data is provided and displayed. Advantageously, real-time processing and display of data is provided such that discussion and collaboration about the experiment may occur, time-resolved data is not lost, and resources are not wasted.Type: ApplicationFiled: May 8, 2008Publication date: August 28, 2008Applicant: MAVEN TECHNOLOGIES, INC.Inventors: William R Rassman, David Ralin, Jason D. Berger, Robert A. Lieberman, Lothar U. Kempen
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Patent number: 7193711Abstract: An imaging method and apparatus are provided, including a light source emitting a polarized light beam, and an optical assembly including a control layer and/or a light reflection surface. The control layer advantageously allows for control over the properties of a generated evanescent wave to optimize an image of a specimen array within the evanescent wave. The light reflection surface includes coupling means used to couple a receptor/capture agent advantageously allowing for flexible control over receptor specific regions.Type: GrantFiled: May 17, 2004Date of Patent: March 20, 2007Assignee: Maven Technologies, LLCInventors: William Rassman, David Ralin, Robert A. Lieberman, Lothar U. Kempen, Herbert Shapiro
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Publication number: 20070058166Abstract: Image data is acquired, processed, and/or displayed in accordance with an embodiment of the present disclosure to display, monitor, and/or demonstrate the progress of an experiment substantially in real-time and with high sensitivity. In one embodiment, at least one time-resolved value of spatially distributed polarization change data is provided and displayed. Advantageously, real-time processing and display of data is provided such that discussion and collaboration about the experiment may occur, time-resolved data is not lost, and resources are not wasted.Type: ApplicationFiled: December 29, 2005Publication date: March 15, 2007Inventors: William Rassman, David Ralin, Jason Berger, Robert Lieberman, Lothar Kempen
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Patent number: 7126688Abstract: Methods and apparatus for scanning of a microarray to provide an image of the microarray are disclosed. Data related to change in polarization state of a scanning light beam for individual points or lines or other portion of the microarray are collected and processed to image the microarray at high resolution and speed.Type: GrantFiled: May 17, 2004Date of Patent: October 24, 2006Assignee: Maven Technologies, LLCInventors: William Rassman, David Ralin, Robert A. Lieberman, Lothar U. Kempen, Herbert Shapiro
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Patent number: 7002686Abstract: Apparatus for acquiring an image of a specimen comprising a cassette having an optical portion holding a specimen array on a TIR surface and being removably matable to a processing portion having a polarized light beam source and a processing polarization-sensitive portion to image the spatially distributed charges in polarization of the specimen array. In one form the array optical portion comprises a transparent slide having a bottom surface with first and second gratings located to direct polarized light to the TIR surface and to direct light reflected by that (TIR) surface to an imager, respectively. The apparatus may include a flow cell integral with the optical portion as well as means for selecting the direction and wavelength of the polarized light.Type: GrantFiled: December 22, 2004Date of Patent: February 21, 2006Assignee: Maven Technologies LLCInventors: Robert A. Lieberman, William Rassman, Lothar U. Kempen, David Ralin
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Publication number: 20050105091Abstract: Apparatus for acquiring an image of a specimen comprising a cassette having an optical portion holding a specimen array on a TIR surface and being removably matable to a processing portion having a polarized light beam source and a processing polarization-sensitive portion to image the spatially distributed charges in polarization of the specimen array. In one form the array optical portion comprises a transparent slide having a bottom surface with first and second gratings located to direct polarized light to the TIR surface and to direct light reflected by that (TIR) surface to an imager, respectively. The apparatus may include a flow cell integral with the optical portion as well as means for selecting the direction and wavelength of the polarized light.Type: ApplicationFiled: December 22, 2004Publication date: May 19, 2005Inventors: Robert Lieberman, William Rassman, Lothar Kempen, David Ralin
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Patent number: 6882420Abstract: Apparatus for acquiring an image of a specimen comprising a cassette having an optical portion holding a specimen array on a TIR surface and being removably matable to a processing portion having a polarized light beam source and a processing polarization-sensitive portion to image the spatially distributed charges in polarization of the specimen array. In one form the array optical portion comprises a transparent slide having a bottom surface with first and second gratings located to direct polarized light to the TIR surface and to direct light reflected by that (TIR) surface to an imager, respectively. The apparatus may include a flow cell integral with the optical portion as well as means for selecting the direction and wavelength of the polarized light.Type: GrantFiled: May 7, 2004Date of Patent: April 19, 2005Assignee: Maven Technologies, LLCInventors: William Rassman, David Ralin, Robert A. Lieberman, Lothar U. Kempen
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Publication number: 20050030535Abstract: Methods and apparatus for scanning of a microarray to provide an image of the microarray are disclosed. Data related to change in polarization state of a scanning light beam for individual points or lines or other portion of the microarray are collected and processed to image the microarray at high resolution and speed.Type: ApplicationFiled: May 17, 2004Publication date: February 10, 2005Inventors: William Rassman, David Ralin, Robert Lieberman, Lothar Kempen, Herbert Shapiro
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Publication number: 20050024642Abstract: An imaging method and apparatus are provided, including a light source emitting a polarized light beam, and an optical assembly including a control layer and/or a light reflection surface. The control layer advantageously allows for control over the properties of a generated evanescent wave to optimize an image of a specimen array within the evanescent wave. The light reflection surface includes coupling means used to couple a receptor/capture agent advantageously allowing for flexible control over receptor specific regions.Type: ApplicationFiled: May 17, 2004Publication date: February 3, 2005Inventors: William Rassman, David Ralin, Robert Lieberman, Lothar Kempen, Herbert Shapiro