Abstract: The invention relates to methods of treating a patient suffering from an IL-33-mediated disorder, such as asthma, comprising administering to the patient an IL-33 axis binding antagonist based on the genotype of the IL1RL1 gene. The invention further relates to methods of determining whether a patient is at increased risk of an IL-33-mediated disorder, as well as methods of determining whether a patient suffering from such a disorder is likely to respond to a treatment comprising an IL-33 axis binding antagonist, based on the genotype of the IL1RL1 gene.

Abstract: Apparatus to produce a three-dimensional object and methods of producing a three-dimensional object are described. In some examples, a first fluid comprising a colorant and a second fluid comprising an absorber to absorb electromagnetic radiation are applied on a layer of particulate material. Application of the second fluid to the layer of particulate material is in dependence on an ability of the first fluid to absorb the electromagnetic radiation.

Abstract: In an example, a method includes in an additive manufacturing process, generating a first object and generating an ancillary object on top of the first object to reduce a thermal gradient of the first object during cooling.

Abstract: In an example, object model data representing at least a portion of an object defining an initial object geometry is received, wherein the object is to be generated by an additive manufacturing apparatus by fusing build material using a radiant heater. Based on a non-uniform radiant heating distribution of the additive manufacturing apparatus, a modified object geometry may be determined, wherein a local modification of the object geometry is determined based on a local radiant heating parameter determined from the non-uniform radiant heating distribution.

Abstract: A 3D printer is disclosed herein. The 3D printer comprises a build material distributor to generate layers of a build material having a right limit temperature of the build material crystallization curve higher than a left limit temperature of the build material fusing curve. The 3D printer also comprises an agent distributor to selectively deposit an energy absorbent fusing agent to a layer of build material; an energy source to emit energy at a set of wavelengths comprised in the range of 430 to 1200 nm; and a controller. The controller is to receive print job data of a 3D object to be generated; control the build material distributor to generate a layer of build material; control the agent distributor to selectively deposit the fusing agent based on the print job data; and to control the energy source to emit energy to the layer of build material to cause build material on which the fusing agent was deposited to melt, coalesce and then solidify upon cooling.

Abstract: An ostomy bag can include one or more sensors for measuring one or more metrics. An ostomy wafer can also include one or more sensors for measuring one or more metrics. The sensors can be temperature sensors and/or capacitive sensors, for example, and the metrics can include bag fill, leakage, skin irritation, and phase of stoma output, among others.

Abstract: An ostomy bag can include one or more sensors for measuring one or more metrics. An ostomy wafer can also include one or more sensors for measuring one or more metrics. The sensors can be temperature sensors and/or capacitive sensors, for example, and the metrics can include bag fill, leakage, skin irritation, and phase of stoma output, among others.

Abstract: Examples include apparatuses, processes, and methods for generating three-dimensional objects. An example apparatus comprises build material distributor and a controller. Examples distribute a particular build layer in a build area of the apparatus over a previous build layer. Examples determine a build layer temperature corresponding to the particular build layer. Examples analyze build layer coverage for the particular build layer based at least in part on a build layer temperature of the previous build layer and the build layer temperature of the particular build layer. Examples selectively recoat the particular build layer with additional build material based at least in part on the build layer coverage for the particular build layer.

Abstract: An ostomy bag can include one or more sensors for measuring one or more metrics. An ostomy wafer can also include one or more sensors for measuring one or more metrics. The sensors can be temperature sensors and/or capacitive sensors, for example, and the metrics can include bag fill, leakage, skin irritation, and phase of stoma output, among others.

Abstract: Examples include apparatuses, processes, and methods for generating three-dimensional objects. An example apparatus comprises build material distributor and a controller. Examples distribute a particular build layer in a build area of the apparatus over a previous build layer. Examples determine a build layer temperature corresponding to the particular build layer. Examples analyze build layer coverage for the particular build layer based at least in part on a build layer temperature of the previous build layer and the build layer temperature of the particular build layer. Examples selectively recoat the particular build layer with additional build material based at least in part on the build layer coverage for the particular build layer.

Abstract: There is disclosed additive manufacturing apparatus comprising: a controller to: receive object data relating to an object to be generated; and define print data for additive manufacture of the object by ejection of a print agent on build material in a pattern corresponding to selective fusing of the build material, wherein the print data is defined based on the object data so that the pattern defines a shield feature embedded within the object to inhibit fusing of build material corresponding to the shield feature relative build material corresponding to an adjacent portion of the object; and a print agent distributor to eject a print agent on build material based on the print data.

Abstract: An ostomy bag can include one or more sensors for measuring one or more metrics. An ostomy wafer can also include one or more sensors for measuring one or more metrics. The sensors can be temperature sensors and/or capacitive sensors, for example, and the metrics can include bag fill, leakage, skin irritation, and phase of stoma output, among others.

Abstract: Disclosed are systems, control mechanisms and methods that apply different printer control fluid parameters when forming internal and external features of a three-dimensional object within an additive manufacturing system. The identification of internal and external features may involve analysing an object model, comprising data describing the object to be manufactured, to identify all edges of a three-dimensional object and determining which of the edges are internal edges and which are external edges of the object. A control fluid strategy can be optimised for different object feature types, to improve mechanical properties of the final object and/or reduce usage of detailing agent.

Abstract: An ostomy bag can include one or more sensors for measuring one or more metrics. An ostomy wafer can also include one or more sensors for measuring one or more metrics. The sensors can be temperature sensors and/or capacitive sensors, for example, and the metrics can include bag fill, leakage, skin irritation, and phase of stoma output, among others.

Abstract: Techniques for automated messaging are described. Some embodiments are particularly directed to techniques for automated business-to-consumer messaging leveraging social-networking information. In one embodiment, an apparatus may comprise a user profile component operative to retrieve a user profile associated with a user account for a messaging service and a messaging automation component operative to receive a messaging initiation from a messaging endpoint on a client device; and configure an automated response based on the user profile in response to the messaging initiation. Other embodiments are described and claimed.

Abstract: A surgical kit for providing a cryoprotective composition configured to be applied during cryotreatment of a patient includes: a first container containing a predetermined amount or volume of a biodegradable and/or bioerodible fluid agent; and a second container containing a predetermined amount or volume of a non-toxic cryoprotectant agent. The predetermined amount or volume of the of biodegradable and/or bioerodible fluid agent and the predetermined amount or volume of a non-toxic cryoprotectant agent are configured to be mixed together to form the cryoprotective composition in which a therapeutically effective amount of the cryoprotective composition deposited in a body space of the patient in proximity to the cryotreatment remains within at least a portion of the body space for a duration of the cryotreatment and at least a portion of a body tissue proximate to the body space is viable after the cryotreatment.

Abstract: Certain examples described herein relate to preparing a base of build material for additive manufacturing. The base is formed from layers of build material that do not form part of an object undergoing additive manufacture. The base is heated by the application of energy, for example using a radiation source. A thermal profile of the base is measured after heating and is used to determine a pattern of application of at least one printing agent to the base. The pattern of application is used to deposit the at least one printing agent upon the base, wherein the presence of the printing agent affects the heating of the base. In this way the pattern of application of printing agent may be used to effect a thermal homogeneity of the base.

Abstract: A maintenance bag of an ostomy system can include fewer sensors than a diagnostic or analytic ostomy bag that is typically used for newer users. The maintenance bag can include sensors and electronics to detect fill level of the bag. The maintenance bag can also include a bag sealing mechanism that can detect drainage events and aid the user to track inventory of the bags. A wafer that can be used with an ostomy bag can include leak sensors configured to detect leak of effluent. The wafer can also include temperature sensors configured to detect inflammation. The wafer can further include a convex interface for better fit with certain users.

Abstract: A cryoprotective composition configured to be applied during cryotreatment of a patient includes at least one biodegradable and/or bioerodible fluid agent and at least one non-toxic cryoprotectant agent. A therapeutically effective amount of the cryoprotective composition deposited in a body space of the patient in proximity to the cryotreatment remains within at least a portion of the body space for a duration of the cryotreatment. At least a portion of a body tissue proximate to the body space is viable after the cryotreatment. A method of protecting a surgical site during prostate cryosurgery is also provided. The method includes injecting a therapeutically effective amount of the cryoprotective composition into the body space, wherein the body space is a periprostatic space of a patient.