Abstract: An apparatus and methods are provided for a CVT primary clutch that provides enhanced adjustability and performance to off-road vehicle drivetrain. The clutch comprises a stationary sheave attached to a center post coupled to an output end of an engine crankshaft. A moveable sheave slides along the center post toward and away from the stationary sheave in response to engine RPM. A spider portion mounted onto the center post is coupled with the moveable sheave by multiple shift arms and ramps. The shift arms roll along the ramps to push the moveable sheave toward the stationary sheave in response to engine RPM. The weight of the shift arms and the angle of the ramps may be adjusted to affect the engine RPM at which the moveable sheave begins to move toward the stationary sheave. A face plate is fastened onto the moveable sheave for protecting internal components of the clutch.

Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Abstract: Processes and systems for making recycle content hydrocarbons, including olefins, from recycled waste material. Recycle waste material may be pyrolyzed to form recycle content pyrolysis oil composition (r-pyoil), at least a portion of which may then be cracked to form a recycle content olefin composition (r-olefin). In some cases, the pyrolysis and cracking may be carried out in different sections of the same furnace, or in different furnaces in the same cracker facility. Pyrolysis conducted in a furnace may or may not require retrofitting a furnace previously used to crack alkanes to form olefins.

Abstract: A hydrocarbon cracker stream is combined with recycle content pyrolysis oil to form a combined cracker stream and the combined cracker stream is cracked in a cracker furnace to provide an olefin-containing effluent. The r-pyoil can be fed to the cracker feed. More specifically the-pyoil is present in said feedstock in an amount of not more than 20% by weight, based on the total weight of the feedstock.

Abstract: A composition having a recycle content value is obtained by reacting a recycle content feedstock to make a recycle content alpha olefin or by deducting from a recycle inventory a recycle content value applied to an alpha olefin composition. At least a portion of the recycle content value in the feedstock or in an allotment obtained by an alpha olefin manufacturer has its origin in recycled waste and/or pyrolysis of recycled waste and/or in thermal steam cracking of recycle content pyoil.

Abstract: The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. In an embodiment, a pharmaceutical composition can be in a liquid dosage form and can comprise a therapeutically effective amount of the compound or a pharmaceutically acceptable salt thereof as an adjuvant and a therapeutic agent. In another embodiment, a method of adjuvant treating a disorder or condition can comprising administering the pharmaceutical composition to a patient.

Abstract: The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: Example embodiments include software for selectively combining outputs for multiple machine learning modules, so as to generate composite values. The composite values may provide more accurate metrics, e.g., composite scores, that may be used to more reliably predict/estimate, for instance, the likelihood of a given lead converting into a customer within a predetermine time interval. In certain embodiments, a math model selectively combines the scores, and the parameters thereof can be selectively adjusted in real time, based on real time data; so as to maintain accuracy of the composite scores. This can lead to enhanced situational awareness, which can be particularly important for enterprise sales representatives, account managers, and so on.

Abstract: The present invention relates to new pyrrolopyridine compounds having the structures of Formula (I)-(IV), wherein the R groups, A, B, C, D and n are as defined in the detailed description, and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Abstract: The present disclosure provides deuterated pyridinone-pyridinyl compounds and compositions useful in the treatment of p38 MAP Kinase mediated having the structures of Formula (I); wherein the A, B, and R groups are as defined in the detailed description. Methods of inhibition of p38 MAP Kinase activity in a human or animal subject are also provided.

Abstract: The present invention relates to new pyrrolopyridine compounds having the structures of Formula (I)-(IV), wherein the R groups, A, B, C, D and n are as defined in the detailed description, and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Abstract: The present invention relates to new sulfonamide pyrrolopyridine compounds and compositions useful in the treatment of JAK-mediated conditions having the structures of Formula (I), wherein the R groups are as defined in the detailed description. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided. Exemplary indications treated by inhibition of JAK kinase activity include, but are not limited to, inflammatory bowel disease, Crohn's disease, ulcerative colitis, irritable bowel syndrome, and Celiac disease.

Abstract: A system includes a test environment and a processor. The processor is programmed to perform, on the test environment, a diagnostic request specifying a plurality of elements of information, responsive to receipt of a successful result of the diagnostic request from the test environment within a predefined timeout period, approve the diagnostic request for execution by fleet vehicles, and otherwise, retest the diagnostic request as a plurality of requests.

Abstract: An account management server, a communication device and a service device are provided for managing access to an account. The account management server, for example, includes, but is not limited to, a storage device configured to store identifying information for each of a plurality of service devices and configured to store an account associated with each of the plurality of service devices, and a processor communicatively coupled to the storage device, wherein the processor is configured to: receive identifying information from a communication device; identify at least one service device whose stored identifying information matches the received identifying information; and grant management access to the account associated with the identified at least one service device to the communication device.

Abstract: The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.