Abstract: Gene therapy compositions and methods related to transposition are provided, e.g., those engineered from Eptesicus fuscus.

Abstract: A method implemented by at least one server for pushing managed package upgrades comprises receiving a dependency graph from an operating entity via an API call that expresses relationships between a set of software packages. A subscriber set is ingested for subscribers of the software packages via an API call to the operating entity that owns the software packages. A per-subscriber dependency graph is constructed expressing relationships between the individual subscriber's delivery operations. The set of packages is delivered based on dependency order of the per-subscriber dependency graph, while applying one or more rules including: i) push schedule rules that allow the first operating entity to specify time-based gates for the deliveries; ii) subscriber exclusion rules that allow the operating entity to exclude specific subscribers; iii) rules for automatic retries of failed operations; and iv) rules to chunk the push upgrade operations.

Abstract: A bucket with a closed bottom with one or more cutouts, indentations or spaces along the outside circumference (or perimeter) of the bottom of the bucket, configured to allow a user to insert his or her fingers therein while the bucket is sitting upright on a surface, such as the ground, a floor, a tabletop, a countertop, or the like. The user moves his or her hand in an upward direction, causing the bucket to rotate or flip in the air. By varying the speed, power, angle, and other factors, the user may cause the bucket to rotate 180 degrees and land on its top, 360 degrees and land on its bottom, or greater than 360 degrees to land on its top or bottom depending on the number of rotations.

Abstract: A method implemented by at least one server for pushing managed package upgrades comprises receiving a dependency graph from an operating entity via an API call that expresses relationships between a set of software packages. A subscriber set is ingested for subscribers of the software packages via an API call to the operating entity that owns the software packages. A per-subscriber dependency graph is constructed expressing relationships between the individual subscriber's delivery operations. The set of packages is delivered based on dependency order of the per-subscriber dependency graph, while applying one or more rules including: i) push schedule rules that allow the first operating entity to specify time-based gates for the deliveries; ii) subscriber exclusion rules that allow the operating entity to exclude specific subscribers; iii) rules for automatic retries of failed operations; and iv) rules to chunk the push upgrade operations.

Abstract: A central floating device with a plurality of peripheral connection points and tethers. The tethers may be retractable, and are of sufficient length to allow the users some amount of spacing distance from each other. Each individual user thus maintains a separation from each other so as not to interfere with each other in the pool, lake, or body of water while remaining tethered together. The floating device may further include cup-holders, lights, storage compartments, and an anchor.

Abstract: A device for orthopedic measurements includes a main housing, a center member, a measurement indicator, and a flexible member. The main housing has a proximal end with a top opening and a distal end with a side opening, and defines a longitudinal axis and includes a main housing cavity. The center member is disposed along the longitudinal axis within the main housing cavity. The measurement indicator is operatively connected to the center member, and is configured and adapted to display a measurement of a distance. The flexible member is threaded through the main housing cavity, and includes a first end and an opposed second end with an eyelet disposed proximate the side opening of the main housing. The eyelet is configured to be drawn away from the main housing, extending the flexible member outward with respect to the side opening to display a measurement on the measurement indicator.

Abstract: A CNC machine comprises a holder for a workpiece to be machined, a tool array comprising one or more tools, a machining arm adapted to select and use one of said one or more tools to machine said workpiece, and a marking device positionable in said tool array and selectable by said machining arm. The marking device comprises an optionally fluid-sealed housing and a marking head mounted in housing for translational movement in a marking plane. The marking head has a marking tip, being moveable in a marking direction substantially orthogonal to said marking plane for marking said workpiece. A controller is used for controlling the translational movement of the marking head and the marking pin. A communicator enables communication externally at least to operate the marking tip but also preferably said translational movement to describe the desired shape of mark to be made.

Abstract: Calendar management devices and systems are disclosed that are configured with hardware to generate a calendar object and a calendar share identifier associated with the calendar object, and to cause the calendar share identifier to be provided to each of a plurality of calendar users. User input is received indicating a new event associated with the calendar object, and in response to the user input, the device(s) are configured to determine an authorization level of the new event based on the user input, generate a calendar event object comprising the authorization level, and automatically send a publication request to a remote server over a network, wherein said sending the publication request directs the remote server to determine a subset of the plurality of calendar users based on the authorization level and to send the event object to each of the subset of the plurality of calendar users.

Abstract: Systems and methods for filter orientation on a control valve are provided. In particular, systems and methods are provided for rotationally orienting a filter retention feature with respect to an application fluid passageway to control forces and stresses exerted on the filter retention feature. Additionally, methods for manufacturing a control valve are provided that enable a rotational relationship between a filter retention feature and an application fluid passageway to be constrained.

Abstract: A device for orthopedic measurements includes a main housing, a center member, a measurement indicator, and a flexible member. The main housing has a proximal end with a top opening and a distal end with a side opening, and defines a longitudinal axis and includes a main housing cavity. The center member is disposed along the longitudinal axis within the main housing cavity. The measurement indicator is operatively connected to the center member, and is configured and adapted to display a measurement of a distance. The flexible member is threaded through the main housing cavity, and includes a first end and an opposed second end with an eyelet disposed proximate the side opening of the main housing. The eyelet is configured to be drawn away from the main housing, extending the flexible member outward with respect to the side opening to display a measurement on the measurement indicator.

Abstract: A device for orthopedic measurements includes a main housing, a center member, a measurement indicator, and a flexible member. The main housing has a proximal end with a top opening and a distal end with a side opening, and defines a longitudinal axis and includes a main housing cavity. The center member is disposed along the longitudinal axis within the main housing cavity. The measurement indicator is operatively connected to the center member, and is configured and adapted to display a measurement of a distance. The flexible member is threaded through the main housing cavity, and includes a first end and an opposed second end with an eyelet disposed proximate the side opening of the main housing. The eyelet is configured to be drawn away from the main housing, extending the flexible member outward with respect to the side opening to display a measurement on the measurement indicator.

Abstract: A solenoid can include an armature, a tube including a ferromagnetic tube material, and an armature stabilizing element. The tube can have a radial tube wall with a thickness of less than about 1 mm.

Abstract: A device for orthopedic measurements includes a main housing, a center member, a measurement indicator, and a flexible member. The main housing has a proximal end with a top opening and a distal end with a side opening, and defines a longitudinal axis and includes a main housing cavity. The center member is disposed along the longitudinal axis within the main housing cavity. The measurement indicator is operatively connected to the center member, and is configured and adapted to display a measurement of a distance. The flexible member is threaded through the main housing cavity, and includes a first end and an opposed second end with an eyelet disposed proximate the side opening of the main housing. The eyelet is configured to be drawn away from the main housing, extending the flexible member outward with respect to the side opening to display a measurement on the measurement indicator.

Abstract: An improved air filter having a frame that permits collapse and compression of the entire filter to save costs associated with transportation and for other advantageous reasons. The ends of the filter frame open to permit collapse of the frame to reduce the volume thereof. The filter frame is made of frame members at opposing frame ends, and each frame member has web panels that open for collapse of the frame, and close for construction of the useful frame. The web panels have legs on opposite lateral edges to form a channel in which filtration media is inserted, and four frame members are attached at opposing ends to form a rectangular frame. The web panels open by removing a temporary fastener, such as adhesive, or by other means.

Abstract: This invention is directed to a method for treating an inflammatory condition, treating haematological and other malignancies, causing immunosuppression, or preventing or treating transplant rejection in man or other animals which comprises administering to a patient a compound that has the structure of Formula (I) or Formula (II) as defined below, or a pharmaceutically acceptable derivative thereof or pro-drug therefor, wherein R?NH2, NHR1, NHOR2, NHNHR2, NHCOR2, and R1?C(1-4)alkyl, C(3-6)cycloalkyl, Cn, where n=1-3, R2=methyl, ethyl, R3=alkyl, cycloalkyl, substituted alkyl, substituted cycloalkyl, aryl, heteroaryl, substituted aryl, or substituted hetrecoaryl; wherein R4, R5?C(1-4)alkyl. Novel compounds according to Formula (III), wherein R6 and R7 are any of H, CH3CO, CH3CH2CO, CH3CH2CH2CO provided that R6 and R7 are not both H, or Formula (IV), wherein R5 and R9 are any of H, CH3CO, CH3CH2CO or CH3CH2CH2CO, having use in such methods, are also described.

Abstract: A method and apparatus are provided for detecting and handling an instruction flush in a microprocessor system. A flush mechanism is provided that is distributed across all of the execution units in a data processing system. The flush mechanism does not require a central collection point to re-distribute the flush signals to the execution units.

Abstract: A tool for measuring, marking, or cutting material, the tool formed of a rigid sheet of transparent material having a plurality of lines formed thereon, and a transparent, non-removable, slip-resistant coating applied to a working surface of the rigid sheet to resist slipping of the tool when applied to the material.

Abstract: A scanning probe microscope comprises a probe module. In some embodiments the module is easily removed from the lateral and vertical scanning mechanisms. The module further comprises one or more vertical motion actuator that may be controlled by a multi-path feedback control loop. By coupling the second vertical motion actuator directly to the probe the speed of the scan may be increased over the speed of prior art microscopes. The feedback loop is part of the probe microscope and feedback paths may be independently designed to create independent control of multiple paths.

Abstract: A pipeline processor has circuits to detect the presence of a register access instruction in an issue stage of the pipeline. A load-miss occurring at a later stage may cause the register access instruction to be marked with an associated bit. The register access instruction progresses down the pipeline and when the flush stage is reached, the processor checks the associated bit and flushes the register access instruction.

Abstract: The insertion polymorphisms based on interspersed elements including LINEs and SINEs is used for the inference of an individual's geographic origin. SINE polymorphisms are identical-by-descent, essentially homoplasy-free, and inexpensive to genotype using a variety of approaches. Using a Structure analysis of the Alu insertion polymorphism based genotypes, the geographic affiliation of unknown human individuals can be inferred with high levels of confidence. This technique to infer the geographic affiliation of unknown human DNA samples can be a useful tool in forensic genomics.