Patents by Inventor David Ray Fiipula

David Ray Fiipula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Arginine deiminase derived from mycoplasma arthritidis and polymer conjugates containing the same
    Patent number: 6132713
    Abstract: A purified arginine deiminase (ADI) obtained from Mycoplasma arthritidis having the amino acid sequence of SEQ ID NO:2 as well as an isolated nucleic acid molecule containing a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO:1 are disclosed. Other aspects of the invention include an expression vector, a cloned gene for expressing the Mycoplasma arthritidis derived ADI, (recombinant) host cells useful in expressing the ADI of the present invention and substantially non-antigenic polymer conjugates containing the ADI of the present invention as well as methods of treating arginine deiminase susceptible conditions in mammals. The arginine deiminase-polymer conjugates have high levels of retained enzyme activity and relatively long circulating lives.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: October 17, 2000
    Assignee: Enzon, Inc.
    Inventors: David Ray Fiipula, Maoliang Wang