Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: Quantum devices with chains of quantum dots for controlling tunable couplings between Majorana zero modes (MZMs) are described. Methods for controlling tunable couplings between MZMs using such chains of quantum dots are also described. An example quantum device comprises at least one superconducting island configurable to support at least one pair of Majorana zero modes (MZMs). The quantum device may further include a region adjacent to at least one MZM of the at least one pair of MZMs, where the region is configurable to realize a chain of quantum dots for controlling a tunable coupling between the at least one MZM of the at least one pair of MZMs and another MZM.

Abstract: A computer server system comprises a communications module; a processor coupled with the communications module; and a memory coupled to the processor and storing processor-executable instructions which, when executed by the processor, configure the processor to monitor resource consumption data to identify a first resource type being provided to a resource requester at a periodic rate; identify a second resource type to replace or offset the first resource type at the periodic rate; and perform operations to automatically provide the second resource type to replace or offset the first resource type at the periodic rate.

Abstract: Apparatus, methods, and systems are disclosed for robust scalable topological quantum computing. Quantum dots are fabricated as van der Waals heterostructures, supporting localized topological phases and non-Abelian anyons (quasiparticles). Large bandgaps provide noise immunity. Three-dot structures include an intermediate quantum dot between two computational quantum dots. With the intermediate quantum dot in an OFF state, quasiparticles at the computational quantum dots can be isolated, with long lifetimes. Alternatively, the intermediate quantum dot can be controlled to decrease the quasiparticle tunneling barrier, enabling fast computing operations. A computationally universal suite of operations includes quasiparticle initialization, braiding, fusion, and readout of fused quasiparticle states, with, optionally, transport or tunable interactions—all topologically protected. Robust qubits can be operated without error correction.

Abstract: Apparatus, methods, and systems are disclosed for robust scalable topological quantum computing. Quantum dots are fabricated as van der Waals heterostructures, supporting localized topological phases and non-Abelian anyons (quasiparticles). Large bandgaps provide noise immunity. Three-dot structures include an intermediate quantum dot between two computational quantum dots. With the intermediate quantum dot in an OFF state, quasiparticles at the computational quantum dots can be isolated, with long lifetimes. Alternatively, the intermediate quantum dot can be controlled to decrease the quasiparticle tunneling barrier, enabling fast computing operations. A computationally universal suite of operations includes quasiparticle initialization, braiding, fusion, and readout of fused quasiparticle states, with, optionally, transport or tunable interactions—all topologically protected. Robust qubits can be operated without error correction.

Abstract: A computer server system comprises a communications module; a processor coupled with the communications module; and a memory coupled to the processor and storing processor-executable instructions which, when executed by the processor, configure the processor to analyze resource consumption data to identify at least one emerging resource requester; generate at least one trigger category that includes the at least one emerging resource requester and at least one other resource requester; receive, via the communications module and from a computing device, a request to present the at least one trigger category; and send, via the communications module and to the computing device, a signal causing the computing device to display an interface that includes a selectable option to accept the at least one trigger category.

Abstract: A computer server system comprises a communications module; a processor coupled with the communications module; and a memory coupled to the processor and storing processor-executable instructions which, when executed by the processor, configure the processor to receive, via the communications module and from a computing device, a signal including location data indicating a location of a user; determine, based on the location data, that the user is located within a threshold distance of a particular merchant; generate a notification indicating a particular multiplier for the particular merchant; and send, via the communications module and to the computing device, a signal causing the computing device to display the notification, the notification including an option to accept the particular multiplier for the particular merchant.

Abstract: Apparatus, methods, and systems are disclosed for robust scalable topological quantum computing. Quantum dots are fabricated as van der Waals heterostructures, supporting localized topological phases and non-Abelian anyons (quasiparticles). Large bandgaps provide noise immunity. Three-dot structures include an intermediate quantum dot between two computational quantum dots. With the intermediate quantum dot in an OFF state, quasiparticles at the computational quantum dots can be isolated, with long lifetimes. Alternatively, the intermediate quantum dot can be controlled to decrease the quasiparticle tunneling barrier, enabling fast computing operations. A computationally universal suite of operations includes quasiparticle initialization, braiding, fusion, and readout of fused quasiparticle states, with, optionally, transport or tunable interactions—all topologically protected. Robust qubits can be operated without error correction.

Abstract: Apparatus, methods, and systems are disclosed for robust scalable topological quantum computing. Quantum dots are fabricated as van der Waals heterostructures, supporting localized topological phases and non-Abelian anyons (quasiparticles). Large bandgaps provide noise immunity. Three-dot structures include an intermediate quantum dot between two computational quantum dots. With the intermediate quantum dot in an OFF state, quasiparticles at the computational quantum dots can be isolated, with long lifetimes. Alternatively, the intermediate quantum dot can be controlled to decrease the quasiparticle tunneling barrier, enabling fast computing operations. A computationally universal suite of operations includes quasiparticle initialization, braiding, fusion, and readout of fused quasiparticle states, with, optionally, transport or tunable interactions—all topologically protected. Robust qubits can be operated without error correction.

Abstract: A set of multiple servers in which each server (a) provides a service having a name or other identifier, and for which each server (b) has a network address that differs from the network addresses of the other servers in the set, and (c) is co-located with a resolution mechanism that maps a name or other identifier of the service that is received from a client to a network address that is local to the resolution mechanism. The resolution mechanisms are operated to enable a client to choose one of the servers as being currently operational and/or accessible to provide the service to the client, and to so choose the server without the client needing to first access the chosen server.

Abstract: An injector system includes a source of injection fluid, a pump device, a fluid path set disposed between the source of injection fluid and the pump device, a fluid control device operatively associated with the fluid path set and a hand held control device for controlling the flow rate of the injection fluid. The hand held control device includes a piston slideably disposed within a chamber and adapted to engage a switch that controls the flow rate of the injection fluid. The fluid control device is adapted to permit purging of air from the fluid path set and to stop flow of the injection fluid to a patient at substantially any pressure or flow rate generated by the pump device for delivering a sharp bolus of the injection fluid to the patient. The fluid control device is preferably part of the fluid path set between the source of injection fluid and the pump device.

Abstract: A fluid delivery system includes a fluid container, two or more pressurizing chambers in fluid connection with the fluid container, a drive mechanism in operative connection with the two or more pressurizing chambers to pump fluid from the fluid container and an outlet in fluid connection with the two or more pressurizing chambers. Each of the two or more pressurizing chambers is formed from a flexible, resilient material that is adapted to be compressed to pressurize fluid therewithin.

Abstract: An injection system includes a fluid delivery system, a drive mechanism, a controller and a tubing set. The fluid delivery system includes a fluid container and a pumping mechanism having an inlet in fluid connection with the fluid container and an outlet. The tubing set is adapted to be placed in removable fluid connection with the outlet of the pumping mechanism and a patient. The drive mechanism is in operative connection with the pumping mechanism to pump fluid from the fluid container. First and second information stores, such as bar codes or RFID tags, are associated with the pumping mechanism and the tubing set, respectively. The controller is in operative connection with the drive mechanism and adapted to read the first information store and the second information store to at least partly control the operation of the drive mechanism based thereon.

Abstract: Solar blind ultraviolet communication systems can provide short to medium range non line-of-sight and line-of-sight links which are covert and insensitive to meteorological conditions. Operation in the solar blind region provides zero background conditions and strong scattering interactions. Scattering provides the basis for transferring information when non line-of-sight conditions exist. Zero background conditions are a result of strong absorption of solar radiation in the upper atmosphere. These conditions make it possible to operate very sensitive wide field-of-view quantum noise limited photon counting receivers, and provide communication systems that perform very differently than free space optical systems that operate in other spectral regions. These systems may be compact and require very low primary power for operation. Non line-of-sight ultraviolet communication systems can provide reliable inter-nodal communications for unattended ground sensor networks.

Abstract: A combined fluid injection and inflation system is disclosed and includes a fluid delivery system including at least one pressurizing device, a fluid path, and a control unit. The fluid path is adapted to connect the pressurizing device to a patient via a catheter including a balloon and inserted in the patient. The control unit is operable to control the fluid delivery system. In operation, the control unit selectively actuates the fluid delivery system to operate in a fluid injection mode or in a balloon inflation mode. In the fluid injection mode the pressurizing device delivers fluid to the fluid path for a fluid injection procedure. In the balloon inflation mode, the pressurizing device delivers fluid to the fluid path for inflating the balloon associated with the catheter. An operator control may be connected to the control unit for controlling the fluid delivery system and may be a handheld device.

Abstract: A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system.

Abstract: A fluid delivery system includes a container for fluid to be delivered to a patient, a continuous pump mechanism in non-removable fluid connection with the container, and an outlet in fluid connection with the pump mechanism.

Abstract: A syringe adapter, which permits use of syringes of various types and sizes to be used with a front-loading injector, includes a piston extension and an adapter face plate. The piston extension includes structure for connecting the piston extension to a drive piston of the injector and a plunger of the syringe. The adapter face plate includes a mounting device for attaching the adapter face plate to an injector and a recess for receiving the distal flange of the syringe. The adapter face plate may also include locking pivot arms for releasably engaging the syringe flange.

Abstract: An injector for injection a fluid into a patient, including: a first pressurizing mechanism adapted to operatively connect with a first fluid container to pressurize fluid therein; at least a second pressurizing mechanism to operatively connect with a second fluid container to pressurize a fluid therein; a single drive; and a transmission to control how power from the drive is distributed to the first pressurizing mechanism of the first container and to the second pressurizing mechanism of the second container to control injection of fluid from the first container and from the second container. The drive can, for example, be an electric motor or other drive.