Patents by Inventor David Repaske

David Repaske has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain
    Patent number: 9157906
    Abstract: The present invention provides methods and compositions for modulating the activity of phosphodiesterase 1B (PDE1B) in intracellular signaling pathways, including but not limited to, dopamine D1 intracellular signaling pathways. The invention also provides methods and compositions for modulating the activities of intracellular signaling molecules, including, but not limited to, DARPP-32 and GluR1 AMPA receptor, via modulation of PDE1B. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate PDE1B activity. The invention also provides methods of treating or ameliorating the symptoms of a disorder, including but not limited to a PDE1B-related disorder or a dopamine D1 receptor intracellular signaling pathway disorder, by administering a modulator of PDE1B, preferably, but not limited to, an inhibitor of PDE1B or an agent that decreases the production of PDE1B.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: October 13, 2015
    Assignees: THE ROCKEFELLER UNIVERSITY, THE CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventors: Paul Greengard, David Repaske, Gretchen Snyder
  • PHOSPHODIESTERASE ACTIVITY AND REGULATION OF PHOSPHODIESTERASE 1B-MEDIATED SIGNALING IN BRAIN
    Publication number: 20130239234
    Abstract: The present invention provides methods and compositions for modulating the activity of phosphodiesterase 1B (PDE1B) in intracellular signaling pathways, including but not limited to, dopamine D1 intracellular signaling pathways. The invention also provides methods and compositions for modulating the activities of intracellular signaling molecules, including, but not limited to, DARPP-32 and GluR1 AMPA receptor, via modulation of PDE1B. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate PDE1B activity. The invention also provides methods of treating or ameliorating the symptoms of a disorder, including but not limited to a PDE1B-related disorder or a dopamine D1 receptor intracellular signaling pathway disorder, by administering a modulator of PDE1B, preferably, but not limited to, an inhibitor of PDE1B or an agent that decreases the production of PDE1B.
    Type: Application
    Filed: November 22, 2010
    Publication date: September 12, 2013
    Inventors: Paul Greengard, David Repaske, Gretchen Snyder
  • Phosphodiesterase acitvity and regulation of phosphodiesterase 1-B-mediated signaling in brain
    Publication number: 20080176961
    Abstract: The present invention provides methods and compositions for modulating the activity of phosphodiesterase 1B (PDE1B) in intracellular signaling pathways, including but not limited to, dopamine D1 intracellular signaling pathways. The invention also provides methods and compositions for modulating the activities of intracellular signaling molecules, including, but not limited to, DARPP-32 and GluR1 AMPA receptor, via modulation of PDE1B. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate PDE1B activity. The invention also provides methods of treating or ameliorating the symptoms of a disorder, including but not limited to a PDE1B-related disorder or a dopamine D1 receptor intracellular signaling pathway disorder, by administering a modulator of PDE1B, preferably, but not limited to, an inhibitor of PDE1B or an agent that decreases the production of PDE1B.
    Type: Application
    Filed: May 8, 2007
    Publication date: July 24, 2008
    Applicants: The Rockefeller University, Children's Hospital Medical Center
    Inventors: Paul Greengard, David Repaske, Gretchen Snyder
  • Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain
    Publication number: 20030211040
    Abstract: The present invention provides methods and compositions for modulating the activity of phosphodiesterase 1B (PDE1B) in intracellular signaling pathways, including but not limited to, dopamine D1 intracellular signaling pathways. The invention also provides methods and compositions for modulating the activities of intracellular signaling molecules, including, but not limited to, DARPP-32 and GluR1 AMPA receptor, via modulation of PDE1B. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate PDE1B activity. The invention also provides methods of treating or ameliorating the symptoms of a disorder, including but not limited to a PDE1B-related disorder or a dopamine D1 receptor intracellular signaling pathway disorder, by administering a modulator of PDE1B, preferably, but not limited to, an inhibitor of PDE1B or an agent that decreases the production of PDE1B.
    Type: Application
    Filed: September 3, 2002
    Publication date: November 13, 2003
    Inventors: Paul Greengard, David Repaske, Gretchen Snyder