Abstract: A server computing device including one or more server memory devices storing a relational database. The server computing device further includes one or more server processing devices configured to receive an ephemeral graph database request. The ephemeral graph database request indicates a selection of data stored in the relational database. The processing devices generate an ephemeral graph database that encodes the selected data in a graph structure and store the ephemeral graph database in binary large object (BLOB) storage at the one or more memory devices. The processing devices receive instructions to apply a graph analytics algorithm at the ephemeral graph database. The processing devices read the ephemeral graph database from the BLOB storage and apply the graph analytics algorithm to the ephemeral graph database to generate a graph analytics result. The processing devices output the graph analytics result and delete the ephemeral graph database from the BLOB storage.

Abstract: Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to express cytotoxic chimeric receptors and various dosing regimens for administering such cells. In several embodiments, the immune cells express a chimeric receptor that targets ligands of NKG2D on tumor cells. In several embodiments, the cancer is a blood cancer, for example, acute myeloid leukemia (e.g., relapsed/refractory acute myeloid leukemia) or myelodysplastic syndrome. In several embodiments, the tumor is a solid tumor, for example, intrahepatic cholangiocarcinoma or other liver tumor, for example, secondary metastases from colorectal cancer.

Abstract: An apparatus includes a first acoustic sensing resonator formed from a silicon substrate and has a first microelectromechanical system. The apparatus also includes a second acoustic sensing resonator formed from the silicon substrate and has a second microelectromechanical system. The second acoustic sensing resonator is arranged on the silicon substrate at a ninety degree (90°) angle with respect to the first acoustic sensing resonator and together the first acoustic sensing resonator and second acoustic sensing resonator form a torque sensor. A high temperature bonding surface is connected to the torque sensor for directly connecting the torque sensor to a metal object.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: A random password policy for a specific user associated with an entity is generated based on a global password requirement. A new password created by the specific user based on the generated random password policy is identified. That the new password complies with a set of requirements specified by the generated random password policy is confirmed.

Abstract: A method includes: capturing, via a navigational sensor of a mobile automation apparatus, three-dimensional point cloud data depicting a portion of an aisle containing a support structure, the support structure having a forward plane facing into the aisle; generating, from the point cloud data, a two-dimensional projection in a facility coordinate system; retrieving, from a stored map, an expected location of the forward plane of the support structure in the facility coordinate system; selecting, from the projection, a subset of regions satisfying a positional criterion relative to the location of the forward plane; determining, based on the selected subset of regions from the projection, an actual location of the forward plane of the support structure in the facility coordinate system; and providing the actual location of the forward plane to a navigational controller of the mobile automation apparatus.

Abstract: A process includes communicating by a first device, with a second device. The communicating includes the first device receiving data from the second device that represents a certificate. The certificate binds a hierarchy of logical identifiers to a cryptographic key. The hierarchy of identifiers includes a first logical identifier that corresponds to a group membership. The process includes authenticating, by the first device, the second device based on the certificate. The process includes allowing, by the first device, a secure connection to be set up between the first device and the second device based on whether the first logical identifier represents that the second device is a member of a first group of devices of which the first device is a member.

Abstract: A method and system are provided for dynamically prioritizing work activity. In an embodiment, an appropriate progression threshold period is stored for work item lifecycle statuses in work item management software. Each time a work item status is set or changed, the period is used by a computer to schedule further work activity by generating a progression threshold timestamp. When progression threshold timestamps are presented sequentially to users, work activity is closely guided across the entire lifecycle of all work items. The present invention is also an alerting system whereby work items can enter a progression alert state.

Abstract: A head covering air filtering device comprising a rigid component comprising a transparent face shield, a fabric component, wherein the rigid component and the fabric component combine to cover an entire head of a user and form a seal around the user's neck. The device further comprises an intake filter to filter all intake air entering the device, an exhaust filter to filter all exhaust air exiting the device, and an air mover causing intake air to enter the device and exhaust air to exit the device.

Abstract: Techniques for generating a retail forecasting model from product-cluster-based estimated elasticity values to forecast the effects of price changes on the demand for a set of products are disclosed. A system generates cluster-based price-elasticity values for a set of products by applying a set of regressive elasticity-estimation algorithms to a set of product data and clustering products based on product descriptions and estimated price-elasticity values. The system uses the cluster-based price-elasticity values for the products to generate the retail forecasting model.

Abstract: A method for verifying entities and provide an electronic transfer between entities comprising: retrieving a first reference number and a first transmit number associated with a first entity repository; generating a first internal profile associated with the first entity; generating a first access token; generating a first external profile associated with the first entity; storing the profiles in a directory; retrieving a second identification of a second access token; identifying a second entity associated with the second external profile using the second identification; identifying a second internal profile from the plurality of internal profiles associated with the second entity; using a second reference number and a second transmit number associated with the second internal profile, identifying a current status and a history of a second entity repository associated with the second internal profile; and initiating the electronic transfer from the first entity repository to the second entity repository.

Abstract: Methods and systems for remote multiplayer gameplay are disclosed. An example method can include joining a multiplayer interactive physical game including first and second players competing in an activity; capturing a first game video of a first player in a first play of the multiplayer interactive physical game, using a first camera on a first mobile computing device in a first gaming area; determining a first object flow associated with the first player from the first game video, by performing an algorithm on one or more frames of the first game video to detect one or more key points of the first player; generating a first analytic based on the first object flow; receiving a second analytic associated with the second player in a second gaming area; and generating a feedback to the first player based on the first analytic or the second analytic.

Abstract: In some embodiments, an apparatus, includes a pad of a printed circuit board (PCB) configured to couple to an electrical component separate from the PCB and a via formed through the pad. The via is offset from a center of the pad such that a distance between the via and a most adjacent trace electrically separate from the via is above a threshold distance.

Abstract: A drug product includes a multidose dry powder inhalation device. The device has a medicament chamber and a desiccant chamber adjacent to the medicament chamber, and a pharmaceutical composition therein. The pharmaceutical composition includes a pharmaceutically acceptable salt of tanimilast. The desiccant chamber is filled with molecular sieves.

Abstract: An exemplary shingle includes at least one coated shingle sheet defining a headlap portion and a tab portion each having opposed upper and lower surfaces. A first line of adhesive is adhered to one of the upper surface of the headlap portion and the lower surface of the tab portion, and includes a first thermally activated adhesive material. A second line of adhesive is adhered to one of the upper surface of the headlap portion and the lower surface of the tab portion, and includes a second thermally activated adhesive material having a minimum activation temperature less than a minimum activation temperature of the first thermally activated adhesive material.

Abstract: A dog locating device to be worn by a hunting dog is provided. The device includes a back pad having a front end portion and a rear end portion thereof. The device includes an abdomen pad having a front end portion and a rear end portion thereof. The device includes first and second adjustable straps coupled between the front end portion of the back pad and the front end portion of the abdomen pad. The device further includes third and fourth adjustable straps coupled between the rear end portion of the back pad and the rear end portion of the abdomen pad. The device includes a plate that is coupled to the back pad. The device includes a spring member that is coupled to the plate, and a flag mounting bracket that is coupled to the spring member.

Abstract: Described herein are systems and methods for the management and control of electrolyte within confined electrochemical cells or groups (e.g. stacks) of connected electrochemical cells, for example, in an electrolyzer. Various embodiments of systems and methods provide for the elimination of parasitic conductive paths between cells, and/or precise passive control of fluid pressures within cells. In some embodiments, a fixed volume of electrolyte is substantially retained within each cell while efficiently collecting and removing produced gases or other products from the cell.

Abstract: Disclosed are compounds, compositions and methods for treating disease, syndromes, conditions and disorders that are affected by the modulation of MALT-1. Such compounds are represented by Formula (I) and Formula (II), wherein the variables are defined herein.

Abstract: A powder inhaler includes a casing having a mouthpiece, an inhalation channel, a container for a powdered medicament, and a metering device with a shuttle having a dosing recess. The shuttle is movable between a filling position, in which the dosing recess is in alignment with an opening of the container to be filled with a dose of the powdered medicament, and an inhalation position, in which the dosing recess is in alignment with the inhalation channel, for enabling inhalation of the dose of the powdered medicament contained in the dosing recess through the mouthpiece. A sealing device is operationally active at a coupling zone of the shuttle with the container when the shuttle is in the filling position, the coupling zone circumscribing the dosing recess and the opening.

Abstract: A door frame and threshold assembly including a substantially closed reservoir tube having a first plurality of spaced apart weep holes therein and a second plurality of spaced apart weep holes, an interior sill portion arranged on a ceiling of the reservoir tube, the interior sill portion having a first sloped surface having a descending slope arranged in a direction towards the plurality of spaced apart weep holes, and an exterior sill portion at least abutting one of a pair of sidewalls of the closed reservoir tube, the exterior sill portion having a second sloped surface having a descending slope arranged in a direction away from the closed reservoir tube, wherein a channel is formed by the ceiling of the closed reservoir tube, an edge of the interior sill portion, and an edge of the exterior sill portion.