Abstract: The invention relates to the therapeutic inhibition of LPA gene expression, and in particular to effective doses and dosage regimes for the therapeutic use of the SLN360 molecule, in the prophylaxis or treatment of conditions associated with elevated levels of Lp(a). Such conditions include stroke, atherosclerosis, thrombosis, and cardiovascular diseases such as coronary heart disease and aortic stenosis.

Abstract: The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.

Abstract: Spring clasps, devices, apparatus, systems and methods for easily attaching and detaching ends of fishing hooks to fishing lures. The opposite end has a hook with a spring catch for closing the hook clasp and allowing the hook clasp to attach to a loop end of a fishing hook. The spring catch can be formed from a rearward bending tip end with two legs each having bent ends attached to a base of the hook. To open the hook clasp, the rearward bent tip of the spring catch can be pushed away from the hook opening. Next, the loop end of a fishing hook can be attached, and the rearward bent tip can snap back in place. Safety clips can also be used to prevent the fishing hooks from being accidentally removed from the clasps. The clasps can be used for attaching jewelry ends of strands such as chains, bracelets, necklaces and anklets together.

Abstract: The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.

Abstract: Double bent metal wires having a spring loaded configuration forming clasps, devices, apparatus, systems and methods for easily attaching and detaching ends of jewelry strands together. The opposite end has a hook with a spring catch for closing the hook and allowing the clasp to attach to a loop end of a fishing hook. The spring catch is formed from two legs each having bent ends attached to a base of the hook by a crimp ring to an end of a jewelry strand. To open the loop on the clasp, the spring catch can be pushed away from the hook opening, for attachment to loop ends of a jewelry strand. The clasps can be used with attaching jewelry ends of strands such as necklaces, bracelets, chains, and anklets together.

Abstract: Double bent metal wires having a spring loaded configuration forming clasps, devices, apparatus, systems and methods for easily attaching and detaching hooks to fishing lures, feather hooks, jig heads, fishing lines, and the like. The clasp can have screw type threads for being threaded into an end of a fishing lure. The opposite end has a hook with a spring catch for closing the hook and allowing the clasp to attach to a loop end of a fishing hook. The spring catch is formed from two legs each having bent ends attached to a base of the hook by a crimp ring. To open the loop on the clasp, the spring catch can be pushed away from the hook opening, for attachment to loop ends of fishing hooks, and the like. The clasps can be used with attaching jewelry strands such as necklaces, bracelets, chains, and anklets together.

Abstract: Double bent metal wires having a spring loaded configuration forming clasps, devices, apparatus, systems and methods for easily attaching and detaching hooks to fishing lures, feather hooks, jig heads, fishing lines, and the like. The clasp can have screw type threads for being threaded into an end of a fishing lure. The opposite end has a hook with a spring catch for closing the hook and allowing the clasp to attach to a loop end of a fishing hook. The spring catch is formed from two legs each having bent ends attached to a base of the hook by a crimp ring. To open the loop on the clasp, the spring catch can be pushed away from the hook opening, for attachment to loop ends of fishing hooks, and the like. The clasps can be used with attaching jewelry strands such as necklaces, bracelets, chains, and anklets together.

Abstract: The present invention is directed to functionalized semiconducting polymers (FSPs) having the following general formula (I): wherein PB is a semiconducting polymer backbone, L is an alkyl, alkenyi or alkoxy chain and CTG is a cationic terminal group. The FSPs may be used as interfacial modifiers in organic electronics, and more specifically organic photovoltaic devices.

Abstract: A A compound having formula (2) wherein A2 is an electron acceptor moiety; C2 is a conjugated bridging moiety; D2 is an electron donor moiety; S2 is a hydrocarbon, a heterocyclic moiety, or a hetero-acyclic moiety; a? is an integer; Z2 is a polymerizable moiety; and e? is the degree of polymerization.

Abstract: A A compound having formula (2) 1