Abstract: The present disclosure relates to pharmaceutical compositions, including dosage forms, such as tablets or capsules, comprising venglustat, in free base, or pharmaceutically acceptable salt form, a diluent/filler and a lubricant, optionally in combination with one or more additional therapeutic agents, to processes for manufacture thereof, and to methods of use in the treatment or prevention of disease.

Abstract: The present disclosure relates to pharmaceutical compositions, including dosage forms, such as tablets or capsules, comprising venglustat, in free base, or pharmaceutically acceptable salt form, a diluent/filler and a lubricant, optionally in combination with one or more additional therapeutic agents, to processes for manufacture thereof, and to methods of use in the treatment or prevention of disease.

Abstract: An insert intended to be assembled in a hole in a sandwich panel including a hollow cylindrical body having a flanged end deformable by a placement tool allowing mechanical connection by deformation with a surface skin of the sandwich panel is provided. The insert includes an anchoring stem in the continuation of the cylindrical body as well as an internal tube intended to collaborate with the placement tool. The anchoring stem has at least one circumferential groove and a peripheral rib, the circumferential groove and the peripheral rib each having a transverse profile that is rounded so as to be able to collaborate with a curable substance.

Abstract: The present disclosure relates to pharmaceutical compositions, including dosage forms, such as tablets or capsules, comprising venglustat, in free base, or pharmaceutically acceptable salt form, a diluent/filler and a lubricant, optionally in combination with one or more additional therapeutic agents, to processes for manufacture thereof, and to methods of use in the treatment or prevention of disease.

Abstract: An insert intended to be assembled in a hole in a sandwich panel including a hollow cylindrical body having a flanged end deformable by a placement tool allowing mechanical connection by deformation with a surface skin of the sandwich panel is provided. The insert includes an anchoring stem in the continuation of the cylindrical body as well as an internal tube intended to collaborate with the placement tool. The anchoring stem has at least one circumferential groove and a peripheral rib, the circumferential groove and the peripheral rib each having a transverse profile that is rounded so as to be able to collaborate with a curable substance.

Abstract: The invention relates to crystalline hydrates of the formula I in which n has a value of from 2.1 to 2.5. The compound is suitable, for example, as an antidiabetic.

Abstract: A process for preparing pyrazole-glycoside derivatives of the general Formula (I) in which the meanings are R1 H and R2 F; or R1 F and R2 H; or R1 F and R2 F; R3 (C1-C8)-alkyl, where one, more than one or all hydrogen(s) may be replaced by fluorine; X (C1-C3)-alkylene, (C2-C3)-alkenylene.

Abstract: The invention relates to crystalline hydrates of the formula I in which n has a value of from 2.1 to 2.5. The compound is suitable, for example, as an antidiabetic.

Abstract: The present invention is directed to the preparation of novel compounds useful in the treatment of hyperlipidemia, arteriosclerosis, hypercholesterolemia, and other related metabolic disorders. More specifically, the present invention is a novel process for the preparation of 1,4-diphenylazetidinone derivatives from ?-substituted amino amides which are protected in the presence of silylating agents and at least one cyclization catalyst whose structural formula is represented by one of the general formula: wherein the various R-groups are defined herein.

Abstract: The present invention is directed to the preparation of novel compounds useful in the treatment of hyperlipidemia, arteriosclerosis, hypercholesterolemia, and other related metabolic disorders.