Abstract: Presented herein are techniques for qualifying, checking and monitoring the use of diagnostic apparatuses and reagents, such as sequencing apparatuses and reagents, to ensure performance and quality of diagnostic methods. In one aspect, a system is provided for determining whether a sequencing run is a qualification run. The system includes a memory configured to store identifiers of sequencing apparatuses and an associated status, a network interface configured to communicate with a sequencing apparatus and a client terminal, and a processor configured to receive a report from the sequencing apparatus via the network interface for a sequencing run, and determine whether the sequencing run is designated as a qualification run.

Abstract: Presented herein are techniques for qualifying, checking and monitoring the use of diagnostic apparatuses and reagents, such as sequencing apparatuses and reagents, to ensure performance and quality of diagnostic methods. In one aspect, a system is provided for determining whether a sequencing run is a qualification run. The system includes a memory configured to store identifiers of sequencing apparatuses and an associated status, a network interface configured to communicate with a sequencing apparatus and a client terminal, and a processor configured to receive a report from the sequencing apparatus via the network interface for a sequencing run, and determine whether the sequencing run is designated as a qualification run.

Abstract: The present disclosure relates to somatic mutation determinations. An example method includes performing whole genome sequencing using a high-throughput sequencing system on nucleic acids from a sample obtained from a subject to generate raw data, transmitting the raw data from the high-throughput sequencing system to a computing system, processing the raw data by the computing system to generate candidate variants and a set of feature values for each candidate variant of the candidate variants, processing the feature values by the computing system using a trained machine learning model to identify somatic mutations from the candidate variants, transmitting results based on the somatic mutations from the computing system to an end device, and displaying a report on the end device based on the results.

Abstract: The present disclosure pertains to techniques that leverage machine learning models to identify tumor-specific mutations through an integrated analysis of next generation sequencing data. In a particular aspect, a computer-implemented method is provided that includes generating sequence reads from one or more samples collected from the same patient, generating variant call files by analyzing the sequence reads corresponding respectively to the one or more samples, comparing variant call files to generate a list of candidate somatic variants, generating, by a classification machine learning model, scores for each of the candidate somatic variants in the list of candidate somatic variants, where the scores are generated based on a plurality of classifications generated by the classification machine learning model, determining, based on the scores, a ctDNA status for the patient, where the ctDNA status is either positive or negative, and generating a report that provides the ctDNA status for the patient.

Abstract: The present invention is a portable resistance machine that allows a user to perform rowing, skiing, paddling, or any other physical activities at any suitable location. The portable resistance machine contains a housing, a pulley, a flywheel, a planetary gear assembly, an anchor, a retraction mechanism, and a pull cord. The housing contains a central gear support. The pulley, the flywheel, the planetary gear assembly, and the retraction mechanism are positioned within the housing. The central gear support is positioned within the housing. The planetary gear assembly is positioned within the central gear support. The pulley and the flywheel are axially connected opposite to each other along the planetary gear assembly. The retraction mechanism is operatively connected to the pulley, where the retraction mechanism is configured to retract the pull cord into a spooled state around the pulley. The anchor is externally connected to the housing.

Abstract: Provided is a method including obtaining a first web message from a device and retrieving values of a profile. The method may include obtaining a first value of a first account based on the profile, respectively. The process may include determining a boundary based on the first value and providing a user interface (UI) to a computing device via a response to the first web message. The UI may include a UI element that is movable from a first configuration to a second configuration, where positioning the UI element in the first configuration and second configuration causes a first and second limit associated with the first and second configuration to be displayed, respectively. The method may include obtaining a second web message having a third value determined from an updated configuration of the UI element and adjusting a second value based on the third value.

Abstract: The present invention is a portable resistance machine that allows a user to perform rowing, skiing, paddling, or any other physical activities at any suitable location. The portable resistance machine contains a housing, a pulley, a flywheel, a planetary gear assembly, an anchor, a retraction mechanism, and a pull cord. The housing contains a central gear support. The pulley, the flywheel, the planetary gear assembly, and the retraction mechanism are positioned within the housing. The central gear support is positioned within the housing. The planetary gear assembly is positioned within the central gear support. The pulley and the flywheel are axially connected opposite to each other along the planetary gear assembly. The retraction mechanism is operatively connected to the pulley, where the retraction mechanism is configured to retract the pull cord into a spooled state around the pulley. The anchor is externally connected to the housing.

Abstract: The present invention is a portable rowing machine that allows a user to perform rowing, skiing, paddling, or any other physical activities at any suitable location. The portable rowing machine contains a housing, a pulley, a flywheel, a planetary gear assembly, an anchor, a retraction mechanism, and a pull cord. The housing contains a central gear support. The pulley, the flywheel, the planetary gear assembly, and the retraction mechanism are positioned within the housing. The central gear support is positioned within the housing. The planetary gear assembly is positioned within the central gear support. The pulley and the flywheel are axially connected opposite to each other along the planetary gear assembly. The retraction mechanism is operatively connected to the pulley, where the retraction mechanism is configured to retract the pull cord into a spooled state around the pulley. The anchor is externally connected to the housing.

Abstract: A portable ski accessory that converts a portable resistance device into a ski-type exercise machine is presented. The ski accessory contains a hanger chassis, a mounting element, a track, a cord, a handle, and a connection element. The hanger chassis contains a cord input portion and a cord output portion. The cord input portion is positioned terminally opposite to the cord output portion along the hanger chassis. The mounting element is connected adjacent to the hanger chassis. The track is positioned within the hanger chassis. The track traverses from the cord input portion to the cord output portion. The cord traverses through the track. The handle is connected to the cord. The connection element is connected to the cord, opposite to the handle.

Abstract: A portable rowing frame that mounts a portable resistance device is presented. The rowing frame contains a front rowing beam, a rear rowing beam, a mounting beam, a rowing seat, at least one leg, and a pedal assembly. The front rowing beam and the rear rowing beam each contains a slider rail and a mounting channel. The front rowing beam contains a first mounting element. The slider rail and the mounting channel traverses from the front rowing beam to the rear rowing beam. The rear rowing beam is attached to the front rowing beam through a connection element. The first mounting element is positioned to the front rowing beam. The mounting beam is attached to the first mounting element. The rowing seat is attached to the slider rail. The legs are distributed about the mounting channel. The pedal assembly is connected to the front rowing beam.

Abstract: The present disclosure provides a system and methods for qualifying a diagnostic apparatus and/or a reagent used by the diagnostic apparatus. Also disclosed are programs therefor.

Abstract: Vibratory separator screens separate solids and/or fluids, methods form said screens and vibratory screen apparatuses utilize said screens. The vibratory separator screens, methods and apparatuses have a mesh portion having a first side of the mesh portion and an opposite second side of the mesh portion, a first hem crimp affixed to the first side of the mesh portion, and a second hem crimp affixed to the second side of the mesh portion.

Abstract: Vibratory separator screens separate solids and/or fluids, methods form said screens and vibratory screen apparatuses utilize said screens. The vibratory separator screens, methods and apparatuses have a mesh portion having a first side of the mesh portion and an opposite second side of the mesh portion, a first hem crimp affixed to the first side of the mesh portion, and a second hem crimp affixed to the second side of the mesh portion.

Abstract: A system and method performing a medical imaging process includes arranging a subject to receive solution comprising nanodiamonds, performing an MRI imaging process to acquire data from the subject, and reconstructing the data to generate a report indicating a spatial distribution of nanodiamonds in the subject.

Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.

Abstract: A system and method for instantly printing PC postage before establishing a postage meter account. The method includes the steps of a meter vendor obtaining a first meter license from the Post for a first meter; loaning the use of a first meter licensed in the customer's zip code to a customer; requesting a second meter license for the customer; initializing the first meter for use by the customer; and transferring the first meter to the Customer's meter license when the second meter license is received. Alternatively, when the second meter license is received a second meter is assigned to the customer and the first meter is reassigned to the meter vendor.

Abstract: A pressure sensitive adhesive composition comprises a poly-&agr;-olefin, a poly-iso-butylene and a compatibilising high surface area stabiliser. The composition exhibits good cold flow and adhesive properties with a high resilience to &ggr;-radiation. A method of preparing the pressure sensitive adhesive composition is also described.

Abstract: A method for treating pulmonary hypertension and other diseases involving a defect in collagen metabolism, by administration of an effective amount of a liposome encapsulated copolymer conjugate antifibrotic composition, is disclosed. The antifibrotic agent is preferably proline analogs, such as cis-4-hydroxy-L-proline (CHOP), 3,4-dehydro-DL-proline (DHP), (R)-(−)-2-thiazolidine-4-carboxylic acid (THP), and (S)-(−)-2-azetidinecarboxylic acid (ACA). Consistent, high loadings (>90%) of the antifibrotic agent are achieved by first forming a dipeptide with L-lysine, after which the dipeptide is copolymerized with the polymer component to form the copolymer conjugate. The polymer is preferably poly(ethylene glycol) having a weight average molecular weight of from about 500 to about 15,000. Efficient delivery and consistent release of the antifibrotic agent inhibits collagen accumulation and treats the diseases involved.