Abstract: A safety device for use in a fluid transfer and/or circulation system of the type which uses a pump to draw water from a reservoir through one or more intake lines each extending from an open end at the reservoir to the pump intake. The safety device connects in-line with the fluid transfer/circulation system, between the open ends of the intake lines and the pump and includes a vacuum pressure sensor, an analyzer and controller, a relay, and a vacuum breaker. Each time the pump is activated, the device analyzes negative pressure levels throughout a start-up period to establish a normal operating pressure window for the particular system.

Abstract: A safety device for use in a fluid transfer system for a swimming pool or similiar application, having a pump which draws water from a reservoir through one or more intake lines each extending from an open end at the reservoir to the pump intake. The device analyzes negative pressure levels in the system and, upon detecting a negative pressure level being outside of a selected operational range, the device deactivates the pump and triggers a vacuum breaker device to eliminate negative pressure in the system, by introducing air from atmosphere into the intake lines thereby removing suction at the open ends of the intake lines. The safety device may further activate warning devices including audible and visible alarms to indicate that the system has been deactivated.

Abstract: The present disclosure relates to HIF-2? inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2? scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.